
Marc Forrest
@MarcForrest7
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Research Assistant Professor @NUFeinbergMed @NorthwesternU @Penzes_Lab. Interested in genetics and neurobiology of autism, schizophrenia and epilepsy.
Chicago, IL
Joined November 2019
RT @bryanjsong: Akap11 mutations greatly increase risk for #bipolar disorder and #schizophrenia. Not much was known about this gene when wā¦.
biorxiv.org
Loss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. We conducted multi-omic analyses of Akap11 mutant...
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RT @Penzes_Lab: Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B. Jessica Christiansenā¦.
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RT @NaturePortfolio: A Review in @NatRevNeurosci describes our current understanding of the complex genetic architecture of schizophrenia aā¦.
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RT @CellReports: Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes .
cell.com
Using NGS approaches, Fazel Darbandi etĀ al. demonstrate that ASD-associated TRs in the developing cortex share substantial overlap in their binding sites. InĀ vitro CRISPRi delineated downstream...
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RT @NUFeinbergMed: Northwestern Medicine scientists have been awarded a $17 million grant to study genetic causes of #autism and #schizophrā¦.
news.feinberg.northwestern.edu
Northwestern Medicine scientists have been awarded $17 million to study genetic causes of autism and schizophrenia, with the aim of developing new drugs to treat the conditions.
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RT @doctorveera: Whole brain(!) in vivo gene editing to correct a point mutation in a ASD mice model. Li, Zhang, et al. Nat Neuro. https://ā¦.
nature.com
Nature Neuroscience - Li et al. developed a base-editing system to edit mutations linked to autism. Targeting a mutation in Mef2c restored Mef2c protein levels in several brain regions and reversed...
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RT @WiringTheBrain: Very good to see this very large study countering strong claims that maternal infection increases risk of autism in offā¦.
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RT @doctorveera: Glad to see the psychiatric genetics researchers introducing the practice of adding polygenic score effect sizes in the MAā¦.
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RT @doctorveera: Nice plot visualizing the effect sizes (vs carrier frequency) of common variants, rare variants, CNVs and polygenic scoreā¦.
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RT @AllenInstitute: The first cellular map of a mammalian brain is here. š§ āØ. Over 6 years and 32 million cells in the making, the completeā¦.
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New Center for Psychiatric Neuroscience being created at @NUFeinbergMed. Even got mentioned in the new release! š.
We're diving into mysteries of the mind. š§ . Our newly launched Center for #PsychiatricNeuroscience is breaking down barriers and uniting scientists across disciplines to unravel the complexities of #MentalHealth.
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RT @k_langin: An NIH advisory group announced today that they're recommending the agency boost its minimum #postdoc salary to $70,000, up fā¦.
science.org
Researchers shouldnāt be in postdoc positions for more than 5 years, the group also suggests
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RT @sohallab: A new review summarizing my current thoughts on the neurobiology of schizophrenia:
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RT @FlyBottleEscape: Just a reminder that Cellpose2.0 is a great, free, fast option to quant all kinds of histology from immediate early geā¦.
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RT @doctorveera: AI reviewing GWAS literature. Looks pretty cool. May be its time for me to retire. š
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RT @Frank_S_David: Fascinating thread on human genetics as a source of drug targets. TL;DR:. ā strong human genetic data boosts odds of sucā¦.
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RT @cedricboeckx: Really nice study of dup15q syndrome, examining developmental and postnatal molecular changes in #autism, using both #orgā¦.
biorxiv.org
Duplication 15q (dup15q) syndrome is the most common genetic cause of autism spectrum disorder (ASD). Due to a higher genetic and phenotypic homogeneity compared to idiopathic autism, dup15q syndrome...
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RT @cedricboeckx: Great use of cortical #organoids from @gtesta72 lab to dissect the effects of copy number variations at 7q11.2 at early sā¦.
science.org
Omics dissection of cortical development in 7q11.23 reveals defects in neuronal maturation and social behavior linked to GTF2I.
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