⚡️GREG_CORDER⚡️
@FlyBottleEscape
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Assistant Professor @Penn • Dept Psychiatry + Dept Neuroscience + Dept Anesthesiology | Pain • Placebo • Poppies • Psychedelics
Philadelphia, PA
Joined March 2016
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain. Now published on the cover of @ScienceAdvances !!!. Improved with projection-specific, pain-active intersectional chemogenetic pain behavior. Check it out 👇.
⚡️🧠Thrilled to share our new preprint on pain-related valence cell-types + circuits — A nociceptive amygdala-striatal pathway for chronic pain aversion. Check out the stellar work of Jessica Wojick, in a co-senior collab with @KorbLab . THREAD 1/13.
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Taking 2+ years to make a KO mouse to then not test them in a chronic pain model is odd; this would take a week to CFA or 3 weeks to SNI. Since the human GWAS was results are from chronic pain patients seems like a reasonable thing to have done
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Noted by Rev 1 in the Peer Review file (comment + author response below), the mouse tested for acute sensory effects is a global knockout for SLC45A4. the paper claims DRG as the locus for the GWAS/behavior impacts on pain. SLC45A4gene is found in near every cell in the🐭brain
This is a cool paper, but not sure if the findings are impressive enough to be too excited about. The authors used a GWAS of a pain phenotype and decided to study a gene (SLC45A4) at a specific locus in detail. The genetic association itself is robust, replicates across.
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RT @doctorveera: This is a cool paper, but not sure if the findings are impressive enough to be too excited about. The authors used a GW….
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RT @JerzySzablowski: Congrats to @ManwalHarb and the rest of the team. Our paper on targeting spatially-defined projections with AAV9.retro….
aiche.onlinelibrary.wiley.com
Neuronal activity underlies the brain function. Different behaviors, physiological processes, and disorders depend on which neurons are active at a given moment. Treating brain disorders without...
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screwed and chopped
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RT @michael_krashes: New paper from the lab with @andrewlutas. Work of the amazing Claire Gao. Important read exploring mechanistic insight….
biorxiv.org
Glucagon-like peptide 1 receptor (GLP1R) agonists like semaglutide drive weight loss through the brain, but insights into their intracellular signaling mechanisms are lacking. Although canonically...
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RT @bertogliolab: Optimized DBS for ACC inhibition produces antidepressant-like effects in mice.
cell.com
Yuan et al. combine deep brain stimulation with neural activity monitoring to optimize stimulation parameters for the anterior cingulate cortex. They show that inhibitory DBS produces rapid, long-l...
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I’m going to present on LUPE — our deep-learning system for automated pain behavior analysis — and the Affective-Motivational Pain Scale (AMPS) model for quantifying complex pain patterns. 📄 Preprint: 💻 Analysis package:
github.com
Contribute to justin05423/LUPE-2.0-AnalysisPackage development by creating an account on GitHub.
Are you curious about headache and migraine pain? Join @GCC_Research for a deep dive into the world of headaches and migraines at the #Pain2025 Workshop, featuring talks from @YarCarLab, @FlyBottleEscape, and Monique Smith from @ucsdbiosciences #PRF
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RT @NINDSdirector: Take a look at this overview of pain research in the NIH Helping to End Addiction Longterm (HEAL) Initiative. It’s the….
ninds.nih.gov
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RT @PainResForum: How do you think the nociceptive amygdala-striatal circuit underlying pain unpleasantness across pain states, described i….
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RT @YoniAshar: 3 years ago, we reported a clinical trial showing substantial reductions in chronic back pain with pain reprocessing therapy….
jamanetwork.com
This secondary analysis of a randomized clinical trial provided 5-year follow-up data for individuals with chronic back pain treated with pain reprocessing therapy, placebo, or usual care.
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Big chunk of this work was all @NIH supported via early career and training fellowships 🙏🏼. K99/R00 @NIDAnews.F31 NRSA @NIH_NINDS.
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain. Now published on the cover of @ScienceAdvances !!!. Improved with projection-specific, pain-active intersectional chemogenetic pain behavior. Check it out 👇.
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another paper, another chance to easter-egg the Metal Gear Solid guard alert exclamation point❗️
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RT @delafuentelab: For years I have dreamt of a tool that could neutralize pathogens the moment they emerge. Today we unveil ApexOracle—an….
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RT @AmandaFakira: The Fakira Lab at the Cooper Medical School of Rowan University is seeking a highly motivated postdoctoral fellow to join….
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PRF was always my favorite site to keep up with the flood of amazing pain science…. So so happy to see it back in original form!.
Check it out! The new interactive website for pain researchers around the globe is live! Webinars, podcasts, interviews and the fan favorite: Papers of the Week! You'll also find lively discussions, jobs, meetings, funding opportunities and more!
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Ohhh 😮 check out what @adaiasand designed/made … . Combined GRIN miniscope + 3 site LFP + EEG/EMG. 🧠⚡️💤. #pain #sleep
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