Penzeslab
@Penzes_Lab
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Research in the Penzes lab aims to understand the neurobiological substrates of mental disorders and to develop new treatments.
Chicago, IL
Joined October 2017
RT @NU_BSA: “About 80% of this increase is caused by broader diagnostic criteria. but 20% is not explained by this,” said Dr. Peter Penze….
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RT @NUAutism: Exciting news! The Center for Autism & Neurodevelopment & @CAM_NUChicago are acquiring the first MIRAVA POLYSCOPE from @Abber….
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RT @CAM_NUChicago: CAM and @NUAutism @NUFeinbergMed @Penzes_Lab have collaborated in acquiring the first MIRAVA Microscope @Abberior. One….
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Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B. Nicolas Piguel using expansion microscopy to visualize bipolar risk gene ANK3 - B69. Euan Parnell dissecting novel developmental roles of KALRN in brain development-poster B70.
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Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B. Jessica Christiansen on novel regulatory sites in schizophrenia risk gene TRIO - poster B67. @MarcForrest7 on homeostatic plasticity in 16p11.2 duplication - poster B68.
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RT @MarcForrest7: Our new review on CNVs in neuropsychiatric disorders is now online 💫. Thanks to Current Opinion in Neurobiology for the o….
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RT @NUFeinbergMed: Northwestern Medicine scientists have identified the cause of a genetic subtype of #Autism and #Schizophrenia that resul….
news.feinberg.northwestern.edu
Northwestern Medicine scientists have identified the cause of a genetic subtype of autism and schizophrenia that results in social deficits and seizures in mice and humans.
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RT @MarcForrest7: Very proud to announce my work on the 16p11.2 duplication mouse model is now published!! It’s been a looong journey with….
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Read about our research in the following NU news article;. Targeting calcium signaling in neurons represent a promising therapeutic approach in schizophrenia. @NUFeinbergMed @Penzes_Lab @NUAutism @ResearchNU.
news.feinberg.northwestern.edu
Targeting calcium signaling in neurons may represent a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study.
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Come learn about the ank2 synaptic proteome with links to seizure susceptibility. Poster D46 at #SfN2022
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If you are interested in #cnv biology and risk factors for #autism and #schizophrenia. Come say hi to Marc's poster on board F23. Now until 5pm @ #SfN2022 !
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Check out our new preprint on disease mechanisms in the #16p11.2 mouse model! This work uses proteomics to help find a genetic driver of seizure and sociability phenotypes 🐁.
biorxiv.org
Neuropsychiatric disorders (NPDs) share genetic etiology and are frequently co-morbid with epilepsy, but the biological basis of this shared risk remains poorly understood. The 16p11.2 microduplica...
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New research from the Penzes lab!.We found schizophrenia risk factor 16p11.2 duplication to cause profound alterations in excitatory iPSC-derived neurons. These effects were present in schizophrenia patient-iPSC, revealing potential pathophysiology.
biologicalpsychiatryjournal.com
Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ...
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Our new paper reveals the role of Homer1 and AnkyrinG in shaping the synapse proteome and controlling dendritic spines. Read it in molpsych!.
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Our new work, published in Neuron, provides novel insight into spinule function. Cutting-edge microscopy allows us to probe the formation, stability and regulation of these structures in live neurons, providing insight into their roles in connectivity.
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New research from our lab identifies a direct link between cytokine signalling and ubiquitinase-mediated regulation of the bipolar/ASD/intellectual disability risk gene, Ank3. #Penzeslab #NUFeinbergMed.
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Read our new review on iPSC-derived models of autism! This work is focused on the role of excitation/inhibition imbalance and its effect on neuronal development. #penzeslab #NUFeinbergMed.
molecularautism.biomedcentral.com
Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social interaction and communication, and repetitive or restricted behaviors. ASD subjects exhibit...
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Our new research reveals that mutations in USP9X lead to neuronal, behavioral and clinical abnormalities, and suggest a mechanism important in #intellectualdisability, #autism, #schizophrenia and #bipolar disorder. #penzeslab @NUFeinbergMed .
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Come and learn about Penzes lab research at #sfn2019!. Poster session Monday 21st, 1-5pm. Theme B neural excitability/synapses and glia. Hall A, 369 - Synaptogenesis and Activity-Dependent Development III.
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See our new and updated website detailing our research, current lab members and publications. #Northwestern @NUFeinbergMed.
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