Vikaas Sohal
@sohallab
Followers
2K
Following
477
Media
9
Statuses
429
Systems neuroscientist / psychiatrist / relapsing mathmo / dad x3 / Rockets fan.
San Francisco, CA
Joined September 2014
New paper online! In 2018, we found a human brain signal that tracks real time fluctuations in mood/anxiety. Now Adam Jackson back-translates this biomarker to mice, dissects its circuit mechanisms, & tests its causal relationship to emotional state. 🧵1/6
6
32
152
Excited to see this in print this morning, coincidentally on the lab's birthday! Here we tackle the question of how the PFC multiplexes social and contextual information using overlapping ensembles of neurons.
nature.com
Nature Communications - How the ensemble encoding of social and anxiety-related behaviors interacts with encoding of context in the prefrontal cortex of mice is not fully understood. Here authors...
4
8
32
I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala https://t.co/zkhSD98GlD
https://t.co/dgNBPSNj5l
nature.com
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
15
67
235
Our preprint detailing our novel approach to identifying personalized neuromodulation targets to treat severe, refractory OCD using brain mapping is now out on MedRxiv. Here, we describe our first SEEG-guided DBS case for OCD at UCSF:
medrxiv.org
Deep brain stimulation has been used to treat severe, refractory obsessive-compulsive disorder (OCD) with variable outcomes across multiple anatomical targets. To overcome these limitations, we...
1
6
18
One more post while I'm at it: my 'Meet-the-Clincian-Expert' @SfNtweets talk, describing my lab's work plus my career path, is now available on demand:
neuronline.sfn.org
This session will describe the speaker’s journey from studying math in college to performing some of the first experiments using optogenetics, training as a psychiatrist, and leading a neuroscience...
0
2
29
Then @ViditaVaidya hosted me at the legendary #HutmentLab @TIFRScience. It was really cool to see @RhythmicSpikes setting up her lab at @NCBS_Bangalore, before finishing my “tour” with @laxminimhans @NIMHANS_BLR. Thanks to all for making this incredibly meaningful trip possible!
1
0
6
Finally, lithium treatment, which we previously found rescues synaptic and behavioral abnormalities in Tbr1 cKO mice, also seems to reverse at least some of the observed abnormalities in neural activity. 4/n
0
0
0
Similar to our prior finding in Shank3 KO mice, multineuron coordination in social ensembles is diminished by Tbr1 cKO. The inability of neurons to act synergistically & encode social information via correlated activity may be a convergent feature of diverse autism models. 3/n
1
0
1
Using neural networks, we found PFC social ensembles that undergo re- (and pre-) activation, plus ensembles which predict approach/avoidance decisions. These signals are all lost in Tbr1 cKO mice. 2/n
1
0
0
New work online! Led by Marc Turner in collab w/ Rubenstein lab. We studied how disruptions in autism genes alter neural activity to produce abnormal behavior in Tbr1 cKO mice & in the process, found new aspects of PFC socioemotional encoding 1/n
biorxiv.org
Disruptions in many genes linked to autism spectrum disorder (ASD) affect synaptic function and socioemotional behaviors in mice. However, exactly how synaptic dysfunction alters neural activity...
1
0
5
Excited to share our Preprint led by talented PDFs, Yu-Tzu Shih PhD and Jason Alipio PhD describing our identification of Experience-dependent PV IN plasticity as a convergent mechanism for Neurodevelopmental Disorders (NDDs) 1/n https://t.co/Rynl0B01mi
1
12
45
Please join the SfN webinar at 1-2pm EST, Wednesday Jan 15. Dr. Vikaas Sohal @sohallab will be showcasing his career as a physician-scientist, together with his great science on psychiatric disease research! We will have plenty time for questions from audience!!
How do specific changes in brain function contribute to various mental health conditions? Vikaas S. Sohal, MD, PhD addresses this critical question in the upcoming #MeettheClinicianExpert webinar moderated by Kei Igarashi, PhD. Gain insights on how he incorporates an
0
2
4
Thrilled to share our new paper in @Nature - "Understanding the neural code of stress to control anhedonia." A wonderful team effort with @_fxia, @VFascianelli and @StefanoFusi2. Check out the thread below. https://t.co/4dw0wZ09OU
nature.com
Nature - Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and...
11
46
241
Many thanks to @CarlJShi & @attila_losonczy for hosting me at @ZuckermanBrain today. So great to see our superstar former tech now developing cool new technologies, and hear from Columbia folks about PFC development, inhibitory synaptic plasticity and much more.
0
1
10
Congrats to @Da_Dr_Zhu on his Young Investigator award from @BBRFoundation !!
0
1
8
Looking forward to #sfn2024! I'll talk on Sat PM and the lab will have posters on Mon PM from @APhensy @LenaShindy Lara Hagopian & Teagan Bullock. Thanks to @christineliuart for flyer production!!
0
10
65
Thanks to @SachinPatelLab for hosting me at @NUFeinbergMed yesterday! Many great conversations about schizophrenia, oscillations and neurodevelopment with @jones_g_parker @penzes2018 and others! Bonus: taking these home to win points with the family
0
0
24
Exciting news! @christineliuart and I are co-hosting an Art of Neuroscience social at #SfN24! Come and showcase your art (submit by Sept 27!) or come and mingle with us and fellow artists and art enthusiasts! 🎨🧠 https://t.co/deIB7VEOIi Please RT! Poster art by @DaniBeckman 🔬
5
45
148
Schizophrenia exists. Mental illness exists. Psychiatric medications can be life-saving. Psychotherapy can be life-saving. Don't let misinformed people tell you otherwise. Enough with the anti-psychiatry propaganda and stigma. ✌️
More gross misinformation from @AhmadRehanKhan Joining forces with another rabid advocate of psychiatric practices with no evidence-based, @jonathanstea . Worth a watch to discover their latest distortions, misrepresentations etc.
58
87
465