Chris Lupton
@LuptonCJ
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Postdoc @MonashUni @MonashBDI - Structural biology - CryoEM - MicroED
Melbourne, Victoria
Joined February 2014
Thrilled to see our work out in @Nature on the #cryoem structure of LYCHOS! A monumental effort from co-first author @bj_charles, the @Dr_Ellisdon Lab, the @Dr_MLHalls Lab from @MIPS_DDB, @HariVenugopal2 from @CryoEM_Monash.
nature.com
Nature - Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the...
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RT @Rhys__G: Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @NatureComms. A team….
nature.com
Nature Communications - Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in...
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RT @ScienceMick: 🍃➡️🧬 First paper from the Martynowycz Lab!.Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by….
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RT @HijaiShin: Excited to share the N&V @RobertoZoncu and I wrote for @NatureSMB on the recent surge of LYCHOS structure papers! 🚀 We prop….
nature.com
Nature Structural & Molecular Biology - The lysosomal transmembrane protein LYCHOS enables activation of the master growth regulator mTORC1 kinase by cholesterol. Here we summarize recent...
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RT @HijaiShin: Amidst the chaos, here's a belated but exciting highlight on the recent LYCHOS structure by @bj_charles @LuptonCJ @Dr_Ellisd….
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RT @drlukey_form: We are hiring! The Formosa Group is hiring a Research Officer to join our program on #Mitochondria, #Metabolism & #Mitoc….
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RT @BradleySpicer: 🚨 Save the Date! 🚨 . I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the….
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RT @evan_healy4: 🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!)….
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RT @HariVenugopal2: Thrilled to see our work on high-resolution #cryoem using a common LaB6 120-keV TEM and sub–200-keV direct electron det….
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RT @LazarouLab: Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data….
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Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex in @ScienceAdvances! Awesome effort from co-authors @bj_charles and @sci_laura with @Dr_Ellisdon doing the heavy lifting leading the project.
science.org
The complete TSC structure reveals how lysosomal targeting proteins and phosphoinositides coordinate mTORC1 inhibition.
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RT @bj_charles: 🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances . Equal-first co-authors @Lupt….
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RT @bj_charles: Highlighted today in @CellCellPress a great perspective piece about our recent work on LYCHOS. @arshukla and colleagues rai….
cell.com
In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transpo...
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RT @arshukla: Delighted to share our preview article now published in Cell @CellCellPress where we highlight the beautiful LYCHOS story fro….
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RT @Nature: Nature research paper: LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR
nature.com
Nature - Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the...
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RT @Dr_MLHalls: 👇Read on to find out about a fascinating #GPCR acting as a domain of a larger transmembrane protein at the lysosome, import….
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RT @EMBLAustralia: So great to see the fantastic, world-leading science of talented ECRs @MonashBDI & being recognised - both in @Nature &….
theage.com.au
Australian scientists have discovered a previously unknown link between plants and humans which could help in the treatment of cancer.
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RT @RobertoZoncu: Spectacular cryoEM structure of LYCHOS by @bj_charles & team out in @nature strongly supports its role as cholesterol sen….
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RT @MIPS_Australia: Out now in @Nature, @MIPS_Australia and @MonashBDI have solved the structure of human cell regulator ‘LYCHOS’, opening….
monash.edu
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