Mike Martynowycz
@ScienceMick
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Our work on ab initio phasing #MicroED data is now published @naturemethods! Big thanks to @markherzik @_KevinCorbett for writing an awesome News & Views (and Mark for reviewing the work). Big thanks to @gonenlab @maxclabbers and Johan for their hard work!
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Another fantastic results published in #JACS. This work shows a great potential of #microED for studying mineralogical and geological samples. ED data were acquired on our Glacios at CeNT UW.
pubs.acs.org
In minerals and inorganic compounds, strong hydrogen bonding can lead to the formation of complex ionic species such as the H3O2– bihydroxide anion and Zundel cation H5O2+. We studied [NaCu2(SO4)2·...
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🍃➡️🧬 First paper from the Martynowycz Lab! Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below! https://t.co/6FJWU5gg4S
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Congratulations to Judge Susan Crawford on her victory, and to the people of Wisconsin for electing a judge who believes in the rule of law and protecting our freedoms.
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What holds your eye lens together? UCLA scientists along with now UB-HWI faculty found out! Using advanced microcrystal electron diffraction, they solved the structure of the abundant lens protein MP20.
nature.com
Nature Communications - Human lens clarity and function depends on well-organized cell junctions. Here, the authors used MicroED to reveal the 3.5 Å structure of MP20, showing that MP20...
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Super stoked that this study is finally out Heroic effort from several people and of course #cryoem #MicroED #FIB 👍👍 Structure of the lens MP20 mediated adhesive junction | Nature Communications https://t.co/l17MWmHr9B
nature.com
Nature Communications - Human lens clarity and function depends on well-organized cell junctions. Here, the authors used MicroED to reveal the 3.5 Å structure of MP20, showing that MP20...
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Our latest work shows how energy filtering, PFIB, and direct electron detection unlock sub-atomic resolution for #MicroED! 🎯 Great work from @maxclabbers and JohanHattne back when I was with @gonenlab at @BC_UCLA. Excited to bring this capability to @UBuffalo!
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Happy to share high throughput ligand and inhibitor screening against enzymes using MicroED. Drug discovery based on structures Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED | bioRxiv
biorxiv.org
Cocktail soaking using single-crystal X-ray diffraction (SC-XRD) has previously allowed high-throughput crystallographic screening of ligands against protein targets. However, protein microcrystals...
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Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @CellCellPress
https://t.co/bTSd8t4POV . What’s new?
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Probing ion channel dynamics at atomic resolution using vanishingly small crystals and #MicroED. Yes, dynamics can be probed even qith crystals... High-throughput MicroED for probing ion channel dynamics | bioRxiv
biorxiv.org
Ion channels play a crucial role in ion transport and are integral to fundamental physiological processes. Therefore, understanding channel structures is essential for elucidating the mechanisms of...
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Whats the best slit width for your energy filter? @maxclabbers systematically tested the settings. The results may surprise you... Characterization of energy filtering slit widths for MicroED data collection | bioRxiv
biorxiv.org
A favorable signal-to-noise ratio is essential for obtaining high-quality diffraction data in macromolecular electron crystallography. Inelastic scattering contributes significantly to the noise,...
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The 7th Challenges in Structural Biology Summit will be 9/9-12/25 at UCLAs Lake Arrowhead Resort. @BrentNannenga and I are taking nominations for speakers. Please write, self nominations are OK. Focus is on methods and challenges. Everyone speaks. Limited to 50 speakers/attendees
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#FeaturedProtocol this week from @gonenlab: The preparation of #microcrystals for #CryoEM enables the acquisition of diffraction patterns from nanometre-sized samples https://t.co/kyphTHoMGT See also accompanying News & Views
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@WiwiSFC @maxclabbers @ScienceMick @calliesayshi @Anna_Shiriaeva_ cody gillman and many others that contributed over the years to this collective #cryoem #MicroED knowledge - now at your fingertips 😍
#FeaturedProtocol this week from @gonenlab: The preparation of #microcrystals for #CryoEM enables the acquisition of diffraction patterns from nanometre-sized samples https://t.co/kyphTHoMGT See also accompanying News & Views
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🔬 Tiny crystals, big impact! Our new @NatureProtocols guide helps scientists unlock the secrets of molecules using #MicroED, a powerful #cryoEM technique. We explain how to prepare samples for this cutting-edge method. #StructuralBiology #ScienceProtocols
https://t.co/bxSOQJJKNg
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