Mike Martynowycz
@ScienceMick
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Scientist @UCLA developing #MicroED. Postdoc @HHMIJanelia. Physics PhD @illinoistech. BS Mathematics and Physics @loyolachicago. Opinions are my own. (he/him)
Westwood, Los Angeles
Joined October 2018
Our work on ab initio phasing #MicroED data is now published @naturemethods! Big thanks to @markherzik @_KevinCorbett for writing an awesome News & Views (and Mark for reviewing the work). Big thanks to @gonenlab @maxclabbers and Johan for their hard work!
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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RT @t_goral: Another fantastic results published in #JACS. This work shows a great potential of #microED for studying mineralogical and geo….
pubs.acs.org
In minerals and inorganic compounds, strong hydrogen bonding can lead to the formation of complex ionic species such as the H3O2– bihydroxide anion and Zundel cation H5O2+. We studied [NaCu2(SO4)2·...
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🍃➡️🧬 First paper from the Martynowycz Lab!.Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below!.
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RT @BarackObama: Congratulations to Judge Susan Crawford on her victory, and to the people of Wisconsin for electing a judge who believes i….
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RT @UB_HWI: What holds your eye lens together? UCLA scientists along with now UB-HWI faculty found out! Using advanced microcrystal electro….
nature.com
Nature Communications - Human lens clarity and function depends on well-organized cell junctions. Here, the authors used MicroED to reveal the 3.5 Å structure of MP20, showing that MP20...
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RT @gonenlab: Super stoked that this study is finally out . Heroic effort from several people and of course #cryoem #MicroED #FIB 👍👍. S….
nature.com
Nature Communications - Human lens clarity and function depends on well-organized cell junctions. Here, the authors used MicroED to reveal the 3.5 Å structure of MP20, showing that MP20...
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RT @UB_HWI: Researchers from UCLA and UB-HWI have pushed the boundaries of electron crystallography, achieving sub-atomic resolution using….
nature.com
Nature Communications - High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein...
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Our latest work shows how energy filtering, PFIB, and direct electron detection unlock sub-atomic resolution for #MicroED! 🎯. Great work from @maxclabbers and JohanHattne back when I was with @gonenlab at @BC_UCLA. Excited to bring this capability to @UBuffalo!
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RT @gonenlab: Happy to share high throughput ligand and inhibitor screening against enzymes using MicroED. Drug discovery based on structur….
biorxiv.org
Cocktail soaking using single-crystal X-ray diffraction (SC-XRD) has previously allowed high-throughput crystallographic screening of ligands against protein targets. However, protein microcrystals...
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RT @svenklumpe: Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published i….
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RT @gonenlab: Probing ion channel dynamics at atomic resolution using vanishingly small crystals and #MicroED. Yes, dynamics can be probe….
biorxiv.org
Ion channels play a crucial role in ion transport and are integral to fundamental physiological processes. Therefore, understanding channel structures is essential for elucidating the mechanisms of...
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RT @gonenlab: Whats the best slit width for your energy filter? @maxclabbers systematically tested the settings. The results may surprise….
biorxiv.org
A favorable signal-to-noise ratio is essential for obtaining high-quality diffraction data in macromolecular electron crystallography. Inelastic scattering contributes significantly to the noise,...
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RT @gonenlab: The 7th Challenges in Structural Biology Summit will be 9/9-12/25 at UCLAs Lake Arrowhead Resort. @BrentNannenga and I are ta….
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RT @NatureProtocols: #FeaturedProtocol this week from @gonenlab: The preparation of #microcrystals for #CryoEM enables the acquisition of d….
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RT @gonenlab: @WiwiSFC @maxclabbers @ScienceMick @calliesayshi @Anna_Shiriaeva_ cody gillman and many others that contributed over the year….
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RT @HWMRI: 🔬 Tiny crystals, big impact! Our new @NatureProtocols guide helps scientists unlock the secrets of molecules using #MicroED, a p….
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