Lucy Walker Lab UCL
@LucyWalkerlab
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We are a research group studying immune regulation based in @iit_ucl University College London @RoyalFreeNHS. Tweets mainly by Lucy.
London, United Kingdom
Joined October 2019
Delighted to share our work on new immunotherapy approaches for #autoimmune diseases. Therapies that target CD28 costimulation impair Treg as well as pathogenic T cells, but it may be possible to avoid this by co-provision of IL-2. 1/6 @NatureComms
https://t.co/gj2qGj2TuE
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🏆Following last week's #NobelPrize announcement, we've pulled together a new virtual issue. 🔎Check it out for must-read articles on peripheral immune tolerance published in the BSI journals:
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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Beautiful work (as always) by Lucy Walker @LucyWalkerlab at #IUIS2025 examining how we boost co-stimulation blockade to treat autoimmunity. #CTLA4 #Tregs A very gripping presentation!! ❤️
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The golden era of type 1 diabetes treatment has begun - finally, we have the first of, hopefully, many treatments to address the immune dysfunction at the root of the condition 🙌🏻
Breaking news! 🎉 The first ever immunotherapy drug for type 1 diabetes, teplizumab, has been licensed for use in the UK. Today, the UK’s medicine regulator (MHRA) confirmed teplizumab is safe and effective for people in the early, symptom-free stage 👉 https://t.co/4dIs13xJiD
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MHRA approval of teplizumab! One step closer to immunotherapy for type 1 diabetes…
After more than 30 years of research funded by Breakthrough T1D, we have arrived at a historic moment. Today, teplizumab has been licensed for use in the UK by the MHRA.🚨 This breakthrough treatment is the first of its kind to delay the onset of type 1 diabetes (T1D) in people
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T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below https://t.co/VgTByRKRCX
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🗞️In the news: #Type1diabetes immunotherapy - teplizumab. It can delay the development of type 1 when used in its early, symptomless stages – before a full diagnosis. The first adult in the UK has been treated with it, but right now it’s only available in research settings.
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The first adult in the UK gets medication to delay the need for insulin requiring T1D. Thats progress! From colleagues at @RoyalDevonNHS, and whilst the therapy is being reviewed for wider NHS use. @elsadiabetes @T1DRAdiabetes @DUK_research @BT1DUK @RAOram
independent.co.uk
New drug offers future hope that people with type 1 diabetes will not need to take insulin
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Thanks for hosting me so well Todd, I had a fantastic visit - so much exciting research going on at @ufdiabetes !
Please join us to hear a world expert on Treg immunobiology and CTLA-4 regulation.
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Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre
https://t.co/dO2v0GWKAn
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Out today in @ScienceMagazine! We show that rising self-antigen levels during infection give self-reactive T cells an opportunity for enhanced TCR signalling. Regulatory T cells of matched specificity counteract this, thereby preventing autoimmunity.
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A milestone for the https://t.co/fi4uh2ZYJ0 study! ‘Teen receives game-changing diabetes drug’ See the full BBC news story here 👇 https://t.co/sBTSPVUCvW
@DiabetesUK @BT1DUK @ImmunologyUoB @BWC_NHS
@parthnarendran @RenukaDias @AlexRichter3
bbc.co.uk
Sam,14, is offered Teplizumab in Birmingham, a new treatment to delay the onset of the condition.
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It was a pleasure listening to the keynote lecture given by @LucyWalkerlab at our 42nd annual meeting! Thank you for a fascinating talk on the role of CTLA-4 in regulating T cell responses🤩 #autoimmunity #Tcells #CTLA4
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Another captivating talk by @carovinuesa at the 3rd International School on Advanced Immunology. Carola told an elegant story of pathogenic mutations in different genes which lead to breaches in B cell tolerance and severe autoimmunity (lupus). Her work @VinuesaLab highlights how
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Wonderful talk by @LucyWalkerlab at the Third International School of Immunology. Lucy described the history of CTLA-4 and her cutting edge research which helped elucidate CTLA4 function incl. CTLA-4 mediated transendocytosis. And how CTLA4 mutations contribute to autoimmunity
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Some incredible science on day 1 of the International School on Advanced Immunology, Awaji Island Japan! Kudos to IFREC / ImmunoSensation for putting this together. 👏@osaka_univ_e @ImmunoSens
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It’s official! We are now Breakthrough T1D UK 🎉 As Breakthrough T1D we’ll continue the journey we started as JDRF: 💙 driving breakthroughs towards a world without type 1 diabetes 💙 helping make every day better for the people who face type 1 💙 working to give everyone
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Natalie is an outstanding scientist and an exemplary team player. We miss her loads @iit_ucl but delighted she is doing so well in the @JenGommerman lab!
Today for National postdoc week I am celebrating Dr. @NatalieEdner. Natalie joined our team in July 2024 having done her PhD with @LucyWalkerlab at UCL.
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Today for National postdoc week I am celebrating Dr. @NatalieEdner. Natalie joined our team in July 2024 having done her PhD with @LucyWalkerlab at UCL.
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Super proud of our latest cohort of MRes Experimental & Translational Immunology students! Congratulations on completing your vivas! @iit_ucl @UCLInfectImm
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