IVIG therapy for ITP comes with heavy dose requirements. A novel Fc-engineered anti-haptoglobin mAb matches IVIG efficacy in primates, at a fraction of the dose. 🔗

🧬 Mesoporous silica nanocarriers delivering siRNA against G6PI show promise in rheumatoid arthritis treatment, reducing joint inflammation, FLS proliferation, and tissue damage in a rat model. Read here: . #Rheumatology #Nanomedicine #Immunology

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New study compares mannan vs. imiquimod models of psoriasis in mice. 🧬. Mannan induces more severe, relapsing disease & distinct cytokine profiles, offering a simpler, chronic model for research. Read here: . #NationalPsoriasisMonth #PsoriasisResearch

💉 Checkpoint inhibitors help many melanoma patients, but not all respond. A study finds that TGF-β activity isn’t a reliable predictor, highlighting the complexity of immune resistance. 🧬🛡️. Read the full article here 🔗

Swieboda et al. show that at birth, NK cells & ILCs are already capable of cytokine production, while NKT-like cells are less abundant & functionally immature. Read the full article🔗 . #Immunology

This #CIDP study links reduced naïve/plasma B cells, increased switched memory B cells, and higher IL-6 to worse outcomes, supporting the role of chronic antigen exposure in disease activity. Read here🔗

📅 August is National Psoriasis Month 🧬. New research compares mannan vs. imiquimod mouse models, finding mannan triggers stronger, longer-lasting psoriasis-like inflammation and may be a simpler, less harmful way to study chronic disease. 🔗

Kromann et al review how intestinal organoids co-cultured with immune cells are advancing our understanding of gut homeostasis, inflammation, infection & cancer. A powerful tool for translational immunology. 📖 . #Organoids #Immunology #GutHealth

🤰 Exposure to gestational diabetes mellitus (GDM) leads to subclinical inflammation, driven in part by obesity but also evident in non-obese individuals. Immune profiling reveals altered NK, T cell, and monocyte populations across metabolic tissues. 👉

From autoimmunity to infectious diseases, if your research bridges basic and clinical immunology, CEI is your home. With read & publish deals, it's never been easier to go Open Access. 🚀. Learn more: . #Immunology.

🧬 New open access article:. A novel TNFAIP3 variant linked to autoimmunity reveals activation of NF-κB, STAT1 & mTOR pathways, highlighting new mechanisms and potential therapeutic targets in HA20. 🔗 . #Autoimmunity #Immunology

🧬 New study identifies a truncated CD74 isoform as a key driver of IL-17 overproduction in stromal-immune cell interactions. Blocking it significantly reduces IL-17, pointing to a promising new therapeutic target. 📖 . #Immunology #IL17 #Inflammation

Karnopp et al. report that vitamin D boosts brain VDR expression and reduces antibody deposits in a neuropsychiatric lupus mouse model, supporting its role in modulating CNS autoimmunity. 🧠 . #immunology

Can TBK1 inhibition treat IBD?. In a DSS colitis model, Hui et al. found that Amlexanox worsens inflammation, despite dampening key pro-inflammatory pathways, underscoring the complexity of immune regulation. 🔗 . #IBD #ClinicalImmunology

T cell exhaustion could hold the key to infliximab resistance in pediatric IBD. Schnell et al. show that non-responders have elevated Lag-3+ CD4+ T cells, pointing to a potential biomarker for therapy failure. Read now🔗

Did you catch our very own Editor-in-Chief, Claudia Mauri, @Mauri_group speaking at this year’s #LIG2025? @London_immuno 🎤✨ . Inspiring insights and impactful science from a true leader in the field!

How does epithelial cell diversity shape host–pathogen interactions in the gut?. This open-access review explores how organoids are advancing our understanding of GI infections by modelling cellular heterogeneity. 📖 Read: .#Immunology

This study in shows that targeting FcγRIIB (CD32B) with antibodies boosts immune responses - not by blocking inhibition, but by engaging activating FcγRs. A novel strategy to enhance vaccines & immunotherapies. 🔗 . #Immunology #FcReceptors

Rims et al. reveal that the frequency and phenotype of citrulline-specific T cells mirror RA disease activity - offering a potential biomarker for immune monitoring in HLA-DRB1*04:04⁺ patients. 📖 #RAresearch

New evidence connects Nck1 signalling to the generation of human Tregs via AKT-FoxO1 - potential implications for designing immune modulators that tweak Treg levels in disease settings. 📖 #ImmuneRegulation