Luca Zaeck 🦠🔬
@LucaMZaeck
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Virologist 🦠 Postdoctoral Researcher @ErasmusMC working on vaccine immunity 💉 Cat Enthusiast 🧶 Musician 🎻🎹
Joined March 2020
waning of antibodies to vaccinia and mpox virus neutralising antibodies 1 year post MVA vaccination. Important to study in the context of questions on vaccine efficacy
eurosurveillance.org
In response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara-Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated. Here, we demonstrate...
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Excited to share our recent contribution in The Lancet Infectious Diseases! In our commentary, we address knowledge gaps regarding mpox immunity and the need for future studies. @Corine_GvK @LucaMZaeck @rorydevries @MarionKoopmans @TheLancetInfDis
thelancet.com
More than 88 000 laboratory-confirmed human monkeypoxvirus (hMPXV) infections were reported in the 2022–23 global mpox (formerly known as monkeypox) outbreak, which presented substantial challenges...
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I am very happy to share the link to our accepted paper in @LSAjournal Super smooth and fast process! Thanks once again to my awesome coauthor @LC_Rijsbergen, @LonnekevNes, @DebbyvanRiel and all others who contributed to this exciting work! https://t.co/NeNLz0DlGD
life-science-alliance.org
Morbidity and mortality from influenza are associated with high levels of systemic inflammation. Endothelial cells play a key role in systemic inflammatory responses during severe influenza A virus...
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Congrats to the talented postdoc @LucaMZaeck who was awarded the yearly van Leeuwenhoek award @NVMM_NL for his first authorship paper in @NatureMedicine on immunity against mpox vaccination&infection. Great work!
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Our recent study to further characterization a MVA-MERS vaccine candidate: Monkeypox Virus Cross-Neutralizing Antibodies in Clinical Trial Subjects Vaccinated with Modified Vaccinia Virus Ankara Encoding MERS-Coronavirus Spike Protein
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Short 'behind the paper' blog of our recent publication in @NatureMedicine on neutralising antibody levels after vaccination against monkeypox 😀 @MarionKoopmans @Corine_GvK @LucaMZaeck @Babs_virology @bart_haagmans @MartLamers
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Historic #smallpox vaccination and #monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but these responses are of lower magnitude after vaccination with MVA-BN, the #vaccine in use for protection against MPXV and smallpox @Corine_GvK
https://t.co/hTLaYmKJqg
nature.com
Nature Medicine - Historic smallpox vaccination and monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but MPXV-neutralizing antibodies are less frequent and of lower magnitude...
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Great to see our paper on monkeypox serology in @NatureMedicine today, the result of a great collaborative effort at @ErasmusMC and @GGD Rotterdam. 🧵 https://t.co/TkxIMkpmcQ
nature.com
Nature Medicine - Historic smallpox vaccination and monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but MPXV-neutralizing antibodies are less frequent and of lower magnitude...
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First observations on vaccinia and monkeypox specific responses in person with infection and vaccination, with and without historic smallpox vaccination https://t.co/iLJVMhVSXF great teamwork again @rorydevries @Corine_GvK @bart_haagmans @GGD_RR @MartLamers
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And they do rotate ! Collective cell motion drive the self organization of mammary gland organoids structures https://t.co/beWgwtjfR8
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Nice use of lattice light-sheet microscopy #LSFM to describe plasma membrane ruffles and macropinocytosis dynamics in macrophages. Brandon Scott lab @sdsmt
https://t.co/gic9sSB1Br
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An immature heart muscle cell (i.e., cardiac myocyte) videoed through a DIC microscope. The worm-like things are the powerhouses of the cell, mitochondria. The "twitching" is a result of capturing some frames during a contraction. #CellBiology #microscopy #SciArt
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Hot off the presses! 🥳🎉 Now published in @VirusesMDPI, our proof-of-concept study adds a spatio-morphological dimension to SARS-CoV-2 infection in the respiratory tract of ferrets! 🔬 https://t.co/hjh10yq3xg
Very excited to announce that our preprint on 3D imaging of SARS-CoV-2 infection using light sheet microscopy is finally available! 🔬🥳🎉 #LSFM #SARSCoV2
https://t.co/y7bWGnWYbO
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Lesser known, I made a load of companion material/slides/exercises for in-person courses, using the same approach of trying to make tricky, interrelated stuff visual & intuitive. It's not online anywhere, but may be one day. Meanwhile, here's a tiny bit (without narration)
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Machine Learning concepts as animal GIFs A thread 🧵
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Using cleared hind limb and head sections in this #LSFM-powered study to highlight that rabies virus doesn't just infect neurons but peripheral neuroglia as well, possibly emphasizing importance of viral immune evasion for disease development! Very happy it's finally out! 🥳🎉
Novel insights in cell tropism and in vivo spread of field #rabies virus: Neuroglia are infected by rabies virus in peripheral neurons, a recent study from @Loeffler_News published with @SpringerNature in Acta Neuropathologica Communications demonstrates. https://t.co/av6GhkXZsU
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Researchers, publishers and press should take a proactive approach to stop the unscientific use of colour in data visualization. @fcrameri @ShepGracie @philipheron present a simple guide to combat the misuse of colour in science. https://t.co/jmv3CEPKKQ
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