Tamara Lotan, MD @LotanLab profile

Tamara Lotan, MD

@LotanLab

Followers

384

Following

161

Media

0

Statuses

34

Molecular pathologist with focus on prostate cancer. Johns Hopkins University.

Joined May 2019

Don't wanna be here? Send us removal request.

Explore tweets Explore followers Explore following

Explore trending content on Musk Viewer

DeNiro • 166621 Tweets

Begoña Gómez • 152850 Tweets

Meyer Habib • 148954 Tweets

Sura • 102474 Tweets

Hollywood • 99662 Tweets

Blanche • 88887 Tweets

Guiraud • 77449 Tweets

Angela Rayner • 65946 Tweets

Washed • 59898 Tweets

Meloni • 58260 Tweets

Julie • 54225 Tweets

Diane Abbott • 51381 Tweets

Abascal • 44805 Tweets

$BOOST • 42908 Tweets

#خادم_الحرمين_الشريفين • 41926 Tweets

Riot • 31124 Tweets

Dick Schoof • 29307 Tweets

Faker • 28154 Tweets

Barquisimeto • 27659 Tweets

Ahri • 27030 Tweets

LOBA COM IFOOD • 26272 Tweets

De Luca • 24111 Tweets

F-35 • 22044 Tweets

#KohLanta • 18416 Tweets

Juvinao • 17053 Tweets

HMRC • 13784 Tweets

Fajna • 12648 Tweets

Boulos • 11009 Tweets

John Kirby

سيد زيان

Clint Eastwood

Kylie Kelce

Stewart-Haas Racing

ابو طارق

Marçal

Andrew Scott

Homelander

Excelsior

Hawkeye

Haberpod

Nico Collins

Meissa

Black Like Me

Pauline

كمال ماضي

MALA COSTUMBRE 6 MILLONES

Amri

#WSIS

#علي_مناحي_نجم_الجمهور

#سلطان_المطيري_فارس_مراجل

Last Seen Profiles

@lovelymiffy78

@linuxsenegal

@Chrisbyew11

@frogglys

@AutodriveToys

@_Pedro_Pablo_

@RichTeaGlutton

@gubby_ayida

@Innovation_HS

@BoxOfToyos

@The_Panda_Jack

@dedbabie

@Jenrai

@blakesmith_11

@churchhugekarp

@wadi73884772

@genuinelydapper

@fantasicinta3s

@ManroRM

@Nike_Futures

Tamara Lotan, MD

@LotanLab

3 years

Beautiful #tweetorial on intraductal and cribriform PCa from @rovingatuscap . While both seem to be associated with aggressive PCa, it is important to note that these can be difficult or impossible to distinguish without immunostains and this has been a confounder. #ProstateJC

Samson W. Fine, MD

@rovingatuscap

3 years

Spectrum of Intraductal Carcinoma of the Prostate (IDC-P) is broader: Most common definition: Expanded intraductal proliferation w/either: ➡️dense cribriform/solid architecture ➡️loose cribriform/micropapillary architecture +marked atypia +/- necrosis #prostateJC #gupath

2

13

35

1

5

20

Tamara Lotan, MD

@LotanLab

3 years

This study raises the interesting question of the extent to which PCa morphology is associated with underlying genomic alterations. To date, there are no known architectural patterns that are invariably associated with specific underlying genomic changes.

1

9

Tamara Lotan, MD

@LotanLab

3 years

Rather, it seems that some morphologies such as IDC-P and cribriform carcinoma are more generally associated with underlying genomic alterations seen in aggressive disease, such as PTEN or BRCA2 loss.

3

0

9

Tamara Lotan, MD

@LotanLab

2 years

@Chucktowndoc @rovingatuscap @IHC_guy @daniel_berney @Williamson_SR @fabiotavora @PathDocBoston Lost in about 80% of NEPC cases in our experience. We have definitely seen NEPC cases with retained expression even when PSA is negative. Usually AR still positive in these cases as well.

1

0

9

Tamara Lotan, MD

@LotanLab

3 years

In this study with @Ecastromarcos we used IHC for basal cells to distinguish IDC-P and invasive cribriform carcinoma. Interestingly, both were associated with bi-allelic BRCA2 mutations. #ProstateJC

1

7

Tamara Lotan, MD

@LotanLab

3 years

This contrasts with other tumor types such as renal cell carcinoma where the appearance under the microscope may be highly predictive of the underlying genomic drivers (eg, VHL loss in clear cell renal cell carcinoma)

0

1

6

Tamara Lotan, MD

@LotanLab

4 years

@rovingatuscap @lalpritu We’ve found it is possible to standardize staining and reporting with the CST D4.3 clone, the BenchMark and a simple dichotomous scoring system. BUT there are rare cases of HGPIN with loss and the natural history of these lesions is uncertain, so it is difficult to be definitive

1

4

6

Tamara Lotan, MD

@LotanLab

1 year

@ModernPathology @JHUPath Thrilled to join this stellar team!

1

0

5

Tamara Lotan, MD

@LotanLab

3 years

@fabiotavora Great question. Homozygous PTEN deletion was significantly more common in cases with gBRCA2 mutations than controls (42% vs 27%). Though we don’t know whether the second hit to BRCA2 occurs before or after PTEN loss. #prostatejc

0

3

4

Tamara Lotan, MD

@LotanLab

1 year

@GladellPaner @drmehrarohit We have a new mouse model of SFPQ-TFE3 carcinoma with very similar bi-phasic pattern—would be interested to know fusion partner in this case!

0

3

Tamara Lotan, MD

@LotanLab

2 years

@brady_urology @allaf_mo @HopkinsMedicine Congratulations, Mo! So excited to see what the next era of Brady Urology will bring!

1

0

3

Tamara Lotan, MD

@LotanLab

1 year

@OSU_Urology @Sood11 @ctleeuro @OSUWexMed @OSUCCC_James Congrats, Akshay! So proud of all you have accomplished!!

1

0

2

Tamara Lotan, MD

@LotanLab

2 years

@FKhaniPath @uroegg Agree. No PTEN loss in isolated HGPIN, nor is it an invasive lesion as is GG1 PCa.

1

0

2

Tamara Lotan, MD

@LotanLab

5 years

@rajalbshah @rovingatuscap @JHUPath @Aiims1742 @soulehoward1 @AGMSKCC Thanks all! It’s long overdue!

0

2

Tamara Lotan, MD

@LotanLab

2 years

@fabiotavora @01sth02 @Chucktowndoc We were just babies ourselves!

0

2

Tamara Lotan, MD

@LotanLab

1 year

@h_alahmadie @ModernPathology @JHUPath Thanks, Hikmat!

0

1

Tamara Lotan, MD

@LotanLab

3 years

@daninava Yes! They seem to be associated with high rate of underlying pathogenic mutations in DNA repair genes (HR and MMR) though the rates differ a bit by center, likely due to differences in how pathologists identify ductal CA.

Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA...

PURPOSE Ductal prostate cancer (dPC) is a rare variant of prostatic adenocarcinoma associated with poor outcomes. Although its histopathologic features are well characterized, the underlying molecu...

ascopubs.org

0

1