🌱 We propose that the action of Yamanaka factors in modulating the epigenome holds immense potential for enhancing tissue repair and unlocking new therapeutic strategies.

📑In this review, we explore the latest findings, highlighting how partial reprogramming mirrors natural regeneration and can revolutionize injury recovery.

🚀 The field of partial reprogramming is rapidly advancing, with groundbreaking discoveries reshaping our understanding of tissue repair!

So happy to share our Review article about reprogramming and regeneration! https://t.co/Y1lJmSrXYB

Excited to share that we are looking for a Scientist 3 to join my lab in Regenerative Medicine at Genentech. Apply here 👇🏼👇🏼👇🏼

When a lab submits a study is a day to celebrate! I share here a fantastic story where we unveiled that DNA damage promotes an MDM2-NICD axis with strong clinical implications. See our manuscript for details and don’t hesitate to comment it. Please RT https://t.co/0kXbNagAB2

As we closed a fantastic year, we wish all the best for 2024 🎉 Pic below: End of Year Celebration @LlucMosteiro lab + Castillo-Azofeifa lab

5. Therapeutic antibodies or genetic deletion shows that Notch inhibition induces hypothyroidism in mice 6. Alagille syndrome patients (characterized by mutations in Notch) show higher prevalence of hypothyroidism

3. The developmental pathway Notch is active in TFC1 and it is required for thyroid hormone synthesis and secretion 4. Notch maintain proper mitochondrial activity and ROS production in TFC1

1. scRNAseq reveals that human and mouse thyroids contain 2 distinct subpopulations of differentiated thyrocytes (TFC1 and TFC2) 2. While TFC1 is the ‘classical’ thyroid hormones producing cell, TFC2 do not express hormone synthesis genes nor thyrocyte TF

Thrilled to share that our paper is now online! 🥳🥳 Thanks to all the authors for this titanic effort! See 🧵 for details!

Excited to share that I am hiring a Scientist 3 to join my lab! If you are a curious and creative scientist, interested in doing cutting edge science in the most stimulating environment, look no more and apply! 👇🏼👇🏼👇🏼

Our next preprint is out on @biorxivpreprint! In collaboration with the wonderful @FrukLab, we describe a new tool for longitudinal monitoring of in vivo senescence. Many thanks to @drew_baca for the fantastic work, as well as @Lil2410 and co-authors. https://t.co/wHQGJIAjB8

The first experiment of the Mosteiro lab! So excited to start my lab with these amazing scientists and looking forward to the adventures ahead! 🔬🧬🧫🥼👩🏽‍🔬

@mcollado_CHUS @MateMaus @FedericoPietr12 @LabPalmero

Extremely happy to celebrate 25 years of amazing science and mentorship by Manuel Serrano! Thanks to the organizers, the invited speakers and all participants for such vibrating atmosphere and the @IRBBarcelona for hosting the event! @MariaAbadMendez @HerranzLab @MaraverLab

We found an increased incidence of hypothyroidism in patients that suffer mutations in Notch genes (Alagille syndrome)

This hypothyroidism triggers a cascade of thermoregulation defects that disrupt homeostasis such as decreased body temperature, increased heat dissipation and increased brown adipose tissue activity.

Alterations in Notch signaling in the thyroid (pharmacological by blocking antibodies or genetic) lead to decreased thyroid hormones in serum and hypothyroidism

Notch is required to maintain proper mitochondrial activity and ROS production in TFC1, essential for the synthesis of thyroid hormones