RT @TaonasL: Therapeutic oligonucleotides are gaining ground in oncology. They offer a new way to target cancer at the genetic level — wit….

RT @JulienMazieres: 🔗 COALA project website is now live!. 👉 A national multidisciplinary consortium supported by th….

What do you want to know?.

RT @MariaAbadMendez: Look at this interesting work from @MaraverLab! FMO as a novel target for lung cancer. Congrats to the whole team! 👇🏻👇🏻.

This work was possible thanks to a fantastic and complementary group of colleagues from @IRCM_MTP @ICM_Montpellier @umontpellier @goteborgsuni @CNIOStopCancer @CIMA_unav @H12Octubre @nyulangone Thanks a lot to all our great collaborators!! Together we are stronger!!!.

As you know, ferroptosis inhibitors are still far from being used in the.clinic, but our findings provide a new way to sensitize cells against them which could.facilitate their clinical translation, at least to treat the leading cause of death by cancer in the.world, i.e., lung.

4. We further dissect the mechanism and uncovered.that FMO4 binds MAT2A, leading to the stabilization of the MAT2A-MAT2B.complex in order to promote the generation of cysteine that in turn regenerates.reduced glutathione to allow GPX4-driven protection against ferroptosis.

2. We demonstrate that FMO is critically required for KRAS-driven lung cancer.generation and maintenance in mice in vivo. 3. We found that FMO4 deletion in lung cancer sensitizes cells against ferroptosis both.in vitro and in vivo, revealing FMO4 as an interesting cancer target.

1. We first found that flavin containing monooxygenase 4.(FMO4) is highly expressed in lung tumors and very low expressed in healthy lung in mouse and lung cancer patients where its expression negatively correlates with patients’ survival.

Thrilled to present our study aiming to identify new vulnerabilities in lung cancer: Joining forces from mouse genetics, thoracic oncology,.metabolism, and AlphaFold fields we dissected the role of a largely unknown but essential protein in cancer, FMO4 🧵.

😂😂.

Terrific start and eager to move on, together we are stronger 💪🏽thanks a lot @JulienMazieres for federating this great adventure.

RT @dplanchard: Ambitious National Network supported by the 🇫🇷 National Cancer Institute which is being set up on lung cancers with molecul….

Indeed life wasn't designed, if not prostate and urinary system would be a bit better separated 😅 although it might be that the X algorithm will not like this crazy idea Alejo 🤣🤣.

Muchas felicidades 🥳🥳🥳🥳.

RT @emiliocasanova9: @MaraverLab @IRCM_MTP Muy bien!!! 😀.

Muchas gracias MxM por ayudarnos a publicitar estilos de vida saludables para combatir #lungcancer y el trabajo que hacemos @IRCM_MTP El interés por la ciencia de los grandes medios audiovisuales es fundamental en la lucha contra esta lacra, y aunando esfuerzos lo lograremos 💪💪.

Wow!!! Congrats indeed!!.

RT @PazAresLab: Seguimos buscando Tecnico de Laboratorio🚀.

Thanks a lot for the continuous support!!! Joining forces between @ICM_Montpellier and @IRCM_MTP make us all way stronger, together we fight better this terrible disease 💪🏽.

Thanks a lot to you for coming! Always a pleasure to discuss science with you and exchange ideas, some of them super crazy hehe, next time in Montpellier!.