Thrilled to share that our paper is now online! 🥳🥳 Thanks to all the authors for this titanic effort! See 🧵 for details!
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1. scRNAseq reveals that human and mouse thyroids contain 2 distinct subpopulations of differentiated thyrocytes (TFC1 and TFC2) 2. While TFC1 is the ‘classical’ thyroid hormones producing cell, TFC2 do not express hormone synthesis genes nor thyrocyte TF
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3. The developmental pathway Notch is active in TFC1 and it is required for thyroid hormone synthesis and secretion 4. Notch maintain proper mitochondrial activity and ROS production in TFC1
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5. Therapeutic antibodies or genetic deletion shows that Notch inhibition induces hypothyroidism in mice 6. Alagille syndrome patients (characterized by mutations in Notch) show higher prevalence of hypothyroidism
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@LlucMosteiro Super interesting study!!! Notch rules 😁 congrats Lluc and to the rest of the team
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