Drew Baker
@drew_baca
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Joined February 2018
We also offer a new perspective and suggest strategies for moving forward 🚀.
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🎯 Antigen depletion by targeted nanoparticles; they can undermine their own targets.
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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đź’Š Dosing complexities that go well beyond what we see with small molecules.
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In this article, we discuss three key challenges holding back the clinical translation of targeted nanomedicine:. 👤 Pharmacokinetics of nanoparticle antibody conjugates; turns out they are not as straightforward as it seems.
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If you're interested in targeted nanomedicine (and open to some opinions), check out our latest piece:. "Reimagining drug nanocarriers: clinical realities and smarter strategies for targeted drug delivery".
pubs.rsc.org
Recent advances in nanomedicine have significantly improved the delivery of small molecule therapies and biologics for cancer treatment, gene therapy, and vaccines, leading to better patient outcomes...
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RT @angew_chem: Nanoparticle-Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology (Ljiljana Fruk and co-workers) #ope….
onlinelibrary.wiley.com
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated...
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RT @FrukLab: Finally, we outline key challenges & opportunities for the future of nanoparticle-mediated targeted protein degradation! https….
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RT @FrukLab: Here we explore:. How nanoparticles can be engineered to selectively degrade disease-relevant proteins
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RT @FrukLab: Excited to share our latest review in @angew_chem on nanoparticle-mediated targeted protein degradation (NanoPD)!. Curious abo….
onlinelibrary.wiley.com
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated...
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RT @FrukLab: 📢 Excited to announce our latest publication in Small, a collaboration between the Fruk Lab and @MunozEspin_Lab!. "Improved Th….
onlinelibrary.wiley.com
Farewell, Therapy-induced Senescence: Galactose-coated micelles enable selective delivery of senolytic drug into senescent cells while sparing healthy ones. This enzyme-responsive system enhances...
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RT @FrukLab: Here, we developed galactose-functionalised micelles targeting senescent cells via elevated lysosomal β-galactosidase activity….
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RT @MunozEspin_Lab: Many congratulations to Dr Muhamad Hartono! Another PhD Thesis from @FrukLab & @MunozEspin_Lab. Thanks so much Muhamad….
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RT @FrukLab: Last Thursday, we had our annual Fruk Lab Retreat, hosted this year by Sidney Sussex College! 🏛️ @SidneySussex A full day of s….
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RT @FrukLab: Here’s a glimpse of the @FrukLab in action at the #BSNM24 presenting their research through talks and posters! 👏 👏 👏✨ https://….
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RT @IwannaMel: And we are off again, for the second day of #BSNM2024, with a keynote talk from @LauraItzhaki @UnivCamPharm and more brillia….
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RT @FrukLab: 🚀 Today, members of the Fruk Lab are attending the British Society for Nanomedicine Annual Meeting! .We're excited to share wi….
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Finally we demonstrate they are effective for in vivo imaging of senescence through both fluorescence and photoacoustic tomography. Using laser induced soundwaves to create an image with the help of our nanoprobe. Thanks @Bohndiek_Lab !!
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Chemicaly we found J-aggregate nanoparticles are composed of dimers of ICG, not pristine ICG like previously thought. With past synthesis methods having over 50% by mass of degradation products still present.
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