Lawrence T Wang
@Lawreate7
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Internal medicine resident @WeillCornell. MD @UCSDMedSchool @ucsd_mstp. DPhil @UniofOxford @NIH @nihoxcam. @PDSoros Fellow. #vaccines #antibodies #malaria
New York, USA
Joined August 2018
Breakthrough in malaria research! 🚨 The RH5.1/Matrix-M™ vaccine shows 55% efficacy against blood-stage malaria in children and >80% against high parasite levels. Safe, well-tolerated, and a key step forward. 🔗 https://t.co/sjiJ2KUKz7
@OxfordMedSci @UniofOxford @KavliFoundation
kavli.web.ox.ac.uk
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Delighted that we have been selected as the cover story(ies) for the current issue of Cell! Thanks to @CellCellPress for selecting us and to everyone for your hard work on this, especially co-authors @Lawreate7 and @brendanfarrell. https://t.co/M3I829eBNZ 1/12
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In the latest issue! Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
cell.com
An in-depth analysis of the naturally acquired antibody response to the malaria vaccine candidate RH5 reveals that infection can induce rare but potently neutralizing antibodies that target the same...
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In the latest issue! Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype
cell.com
Analyses of human monoclonal antibodies against the Plasmodium falciparum blood-stage protein PfRH5 define the antigenic landscape of this molecule in high resolution to determine antibody properties...
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The new issue is out 👉 https://t.co/7FRErzTZZr Featuring allogeneic CD19-targeted CAR-T therapy for severe refractory autoimmune diseases, and an in-depth analysis of antibody responses induced by malaria infection and vaccine candidate RH5. The cover image shows a
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Very pleased to share our comprehensive review on monoclonal antibodies against circumsporozoite protein and how this emerging tool might aid global efforts to control malaria, published today in Nature Immunology! @AzzaIdris_1, we did it! :) https://t.co/yLtsEH5YP2
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Congrats to all for the huge collaborative effort, especially co-authors @Lawreate7 and @AndrewCooperajr, and my excellent summer student Maciej Maciuszek for helping me with some of the many crystal trays. And a big thanks to Josh and @ParasiteMatt for inviting me on board. 2/n
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Congrats to all the other authors and our pioneering leaders @ParasiteMatt @S1monJDraper, and Joshua Tan. Special shoutout to @NIHOxCam which enabled me to work on these collaborative projects between NIH and Oxford!
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Wang et al describe rare RH5 antibodies induced by natural infection and show that these antibodies also target the same epitopes as potent vaccine-derived counterpart antibodies.
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Barrett et al present a comprehensive analysis of vaccine-induced RH5 antibodies and identify a germline antibody lineage that produces highly potent antibodies.
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We co-published b2b papers describing >400 human monoclonal antibodies against the malaria blood-stage antigen RH5! These data will guide testing of current RH5-based vaccines in Africa and improvement of future vaccine candidates. https://t.co/ldnyVG4dPg
https://t.co/1z5dLhIeSp
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Doctors Without Borders challenges pharma by releasing costs for a key clinical trial.
statnews.com
In a challenge to the pharmaceutical industry, Doctors Without Borders has revealed the detailed costs of a study it ran for a tuberculosis treatment regimen.
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Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: https://t.co/E8zXxQoI1l
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Phase II trial where monoclonal antibody L9LS protected 60-70% of children in Mali against malaria for 6mo! Dream come true to see something I pipetted translate into protecting at-risk kids. Can’t wait for the phase III data! #WorldMalariaDay2024
https://t.co/aK08F9hvdx
nejm.org
Subcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal antibody administered subcut...
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Second-generation mosquito nets prevented 13 million malaria cases and 25,000 deaths in large pilot programs.
statnews.com
Second-generation mosquito nets prevented 13 million malaria cases and 25,000 deaths in large pilot programs.
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Congratulations to all the 2024 #PDsoros fellows, welcome to the family and can’t wait to meet you!
🎉 Drumroll, please! Meet the 2024 #PDSoros Fellows! 🗽 Selected from 2,300+ applicants, these 30 exceptional graduate students are changing the game in their respective fields. Click the link to get to know these trailblazers! #ImmigrantExcellence 🎓🎉 https://t.co/xuEgziTmwc
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Matched to my #1 residency program, Cornell’s physician scientist track! Thank you to my family, friends, mentors, and organizations like @PDSoros @NIHOxCam @ucsd_mstp who supported me along this long road.
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Over the moon to share that this has now been published in @Nature! Congrats to everyone involved! Check it out here - https://t.co/QlxblnVV6Z Or watch us chat about it here - https://t.co/GVz8H07vgq
Stoked to share our latest pre-print! Using cryo-EM, we determined the structure of the PfRCR complex, an essential protein complex required for red blood cell invasion by the deadliest form of malaria. 🧵 https://t.co/tzVwmTgfIP
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Mechanistic study showing why an adenovirus-based HIV vaccine failed to provide protection. Honored to have contributed to this work as a @NIH postbac IRTA, a happy ending to a long scientific odyssey.
science.org
HIV vaccine–induced cytotoxic T cells kill HIV-infected targets poorly due to low T cell receptor antigen sensitivity.
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A new #NIAID study, published in Science, shows strong responses from immune cells called CD8+ T cells may play a key role in an effective #HIV #vaccine. This study could guide development of future HIV vaccines and immunotherapy approaches. Read more: https://t.co/rX33yUKjcW
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