Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: https://t.co/E8zXxQoI1l

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵

1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. https://t.co/bUQetIShiF

Check out our recent work describing how vaccination can rewire the baseline immune status of healthy individuals!

In our new paper @PNASNews we show that previous cardiovascular disease increases susceptibility to ICI-myocarditis development by recruiting autoimmune myosin specific TRM cells to the heart! https://t.co/Vt6v4FTooc @DrCihakovaD @TaejoonW @AbdelDaoud20503

Finally out: Characterizing T cell specific responses to vaccine and infection in HLA-DPB1*04-restricted patients across 4 time points. Thank you Philip Mudd and Ali Ellebedy for inviting me into this amazing data set. Paper: https://t.co/lJe8U48xZQ

So many great institutions and people supported me over those years. The best part completing my thesis was writing the acknowledgments. Thank you all... @SidneySussex @MedCambridge @NIAIDTraining @DrAimeeLee @hollern_daniel @DrChrisHourigan @ChenZhao2011 @rohitfarmer

I'm honored to be recognized among my peers in @NIHOxCam. The program's unlimited flexibility + lack of boundaries allowed me to focus on learning & follow the science wherever it led. So grateful to @TsangLab, Ken, @plyons34 & many others for guidance https://t.co/NJZ4XI4n6y 1/2

Imagine a patient at initial presentation with an immune-mediated disease; rather than focusing on tissue/antibody-based diagnosis, you treat based on a test that captures the patient's global immune health. Another great step in that direction from my colleagues @tsanglab

#MLCB2024 deadline extended to June 17!!

There's been amazing coverage of our new paper @Nature https://t.co/qkrUksBYVW but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...

Sir Francis Galton on the Central Limit Theorem

May issue of immunity: https://t.co/mIjKcs7Uxp Open access link to our paper: https://t.co/E8zXxQoI1l #SciArt #SciComm

More of Sarah's nature/biology inspired art books, prints and design work:

..individual immune systems illustrated as leaves...past encounters with caterpillars shape each leaf like the exposures and environmental inputs that shape immune systems. Vividly colored leaves represent individuals who exhibit a shared "naturally adjuvanted" immune setpoint.

It's so meaningful to share this chapter of work with my colleagues @TsangLab with my wife Sarah, who created the cover for @ImmunityCP. Days spent working together while in grad / art school, overlooking our garden in Cambridge, were some of the happiest in my life :) 1/

New issue online! Cover depicts work from @TsangLab & @MPMule &co identifying a "naturally adjuvanted" state in individuals who respond more robustly to unadjuvanted vaccines. Artwork by Sarah Hopkins https://t.co/HsfzGggySP

Our latest @ImmunityCP paper made cover! Congrats and thanks to Sarah Hopkins for the beautiful art work. @MPMule.

Our collaborators develop modeling that helps identify multi-omic #immune #signatures #bioinformatics @LeyingGuan @skleinstein @JeremyGygi @a_konstorum + others https://t.co/B1zOvFJiW9

Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. https://t.co/gN27A13npx

Our paper @ImmunityCP reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n