Randy Larsen
@Larsen_in_Lab
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Molecular Oncologist @ UT Southwestern | St. Jude Graduate School of Biomedical Sciences Alum | Postdoc studying fusion driven sarcomas in the McFadden Lab |
Memphis, TN
Joined May 2021
šHey @utswcancer @UTSWMedCenter @UTSWCancerBio @UTSWHemeOnc @UTSWScience @UTSW_Pathology @UTSWMolBiol @utswimmuno DON'T MISS the next #KomenBreastCancerForum feat. Dr. Mikala Egeblad @megeblad @JohnsHopkins 11/19 9am IN PERSON #InnateImmunity #Metastasis #TMEhost @MalladiLab
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My lab will be recruiting a PhD student this year! Have a look and apply if it sounds interesting!
adroverlab.com
Investigating the role of neutrophils in tumour progression, microenvironment dynamics and metastatic spread Application deadline: 5th of November, 2025 Project background and description Our...
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A big piece of my thesis work is out today! Iām thrilled to share this study from @HannaLabPurdue and I, where we found that non-tumor cells can promote tumor growth in DICER1 cancer predisposition. Enjoy! https://t.co/rQB45UBwSl
cell.com
Patients with DICER1 cancer predisposition typically harbor a germline heterozygous inactivating mutation in DICER1. Whether DICER1 mutant non-cancerous cells contribute to tumor promotion was...
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Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence: Cell Reports https://t.co/aGnBI7m2KZ Latest from @hatleylab
cell.com
Gadek et al. show that embryonal rhabdomyosarcoma formation is defined by the presence of primary cilia and limits SHH pathway competency in early endothelial progenitor cells that disappear during...
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We have a new episode out now! Learn how Dr. Mark Hatley (@hatleylab) from @StJudeResearch is using #rhabdomyosarcoma to study the developmental origins of pediatric cancer: https://t.co/qb9GVwiipX
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Proud to share @nisetoās (new PI @TheCrick) paper: As a postdoc (@CSHL/@HopkinsMedicine), he found #NETs in necrotic tumorsāI shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis. https://t.co/gsaUTA1dfw
@JHU_BDP @Nature
nature.com
Nature - Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here.
adroverlab.com
Open postdoctoral position at the Cancer Macroenvironment Lab led by Dr. Adrover at the Francis Crick Institute in London
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@MolOnc_StJude grad students represent! @Larsen_in_Lab from @hatleylab won St Jude Grad School Research Achievement Award, with @HaydenMalone3 from @TheRobertsLab1 as a finalist and @bsteve00 from @hatleylab with an honorable mention. We appreciate all our great students!
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Had a great time in Punta Cana this week presenting my work on DICER1 Syndrome in RMS. Thanks for putting on a fantastic Animal Models of Cancer meeting @Fusion_Conf! Heading back with lots of new friends and new ideas!
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@hatleylab graduate student Grace Adkins strongly represented @stjudegraduate during the St. Jude Scientific Advisory Board poster session. Way to represent!
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Together, they conquered worlds, founded nations, and took down a mouse. Happy Halloween from the Hatley Lab! š
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Some superheroes donāt wear capesā¦they are called PostDocs! Happy PostDoc appreciation week to Chan Hwang and @jaackdhopkins.
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We are hiring! We have an open Senior Laboratory Research Scientist position in our lab at the Francis Crick Institute in London. Please apply if interested! The deadline is the 1st of September. More info on our new website https://t.co/ll4n6CuBLX (see āVacanciesā section)
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Exciting work, well done @JavedKhanOmics and group!
Check out our latest manuscript describing a potent bicistronic CAR (BiCisCAR) targeting both FGFR4 and CD276 for treating @Rhabdomyosarco
https://t.co/ppN3xY2PFI
@theNCI @NCIResearchCtr
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Fantastic review, well-done @HaydenMalone3 and @TheRobertsLab1!!
Chromatin remodellers as therapeutic targets https://t.co/enqLBZaBIM This review by @HaydenMalone3 & Charles Roberts @TheRobertsLab1 discusses progress in therapeutically targeting chromatin remodellers, with a focus on SWI/SNF complexes, which are often dysregulated in cancer
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Congrats Jose, so happy for you! Cannot wait to see all the exciting results generated by the Adrover Lab!!
I am delighted to announce that I will soon join @TheCrick Institute in London! My lab will study how cancer affects the host "macroenvironment", especially the hematopoietic, cardiovascular, and immune systems. Sounds interesting? Join us!
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New manuscript! š§µ 1/3: What is a #dependency? How do #cancer #dependencies relate to developmental lineage? Can we capitalize on these for precise pediatric #cancer #therapy? These are the questions that @ElaineRitterPhD and I discuss:
pubmed.ncbi.nlm.nih.gov
The quest for effective cancer therapeutics has traditionally centered on targeting mutated or overexpressed oncogenic proteins. However, challenges arise in cancers with low mutational burden or...
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(1/4) Iām super excited to share that my first, first author review is finally out š„³ In this pub, @hatleylab and I discuss the interplay between RMS cells of origin, driver mutations, and location specificity. https://t.co/Q46Hw6f6M8
pubmed.ncbi.nlm.nih.gov
Rhabdomyosarcoma (RMS) is a pediatric embryonal solid tumor and the most common pediatric soft tissue sarcoma. The histology and transcriptome of RMS resemble skeletal muscle progenitor cells that...
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