WithersLab
@LabWithers
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Lab of David Withers @unibirmingham. ILCs | Mucosal Immunity | Tumour Immunity
England, United Kingdom
Joined December 2019
Really great to have our collaborative study with @Hepworth_Lab and @ClatworthyLab now published. In this study we developed our dynamic labelling of lymphoid tissue (Dutton et al., Sci Immunol. 2019) to now visualise immune cell migration into and out of tumours. 1/8
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Relocating the lab to the Oxford Centre for Immuno-oncology going really well. Such a great research environment. We have new positions available, including this post-doc position: New address is: david.withers@immonc.ox.ac.uk - email to find out more.
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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I am delighted to announce our recent Wellcome DA success with @ActonLab and @ClatworthyLab. Super exciting opportunity. If interested in joining our team as a post-doc please contact any of us for more info.
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Great to see these two papers come out together today: . Has been such a great collaboration with many groups, particularly the Clatworthy Lab. Congratulations again Colin and Isaac @ColinYCLee @ClatworthyLab.
nature.com
Nature Communications - Natural killer (NK) cells control tumor growth through direct cytotoxicity and recruitment of other leukocytes. Here, using photoconversion-based labeling to track the fate...
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5 of 5.Key finding #3: Administration of IL15/IL-15ra caused distinct NK tumour resident state that maintained effector functions and appeared to enhance tumour control (Fig 6). Many thanks to all involved, particularly @IWD_Sci, @ColinYCLee, @ClatworthyLab.
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4 of 5.Key finding #2: Validation of transcriptomic changes confirmed really rapid changes in NK cells after tumour entry: upregulation of distinct integrins (e.g. CD49a) and loss of key effector functions (e.g. production of CCL5, IFNg) occurs after only 24hrs. See Fig 2/3.
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3 of 5.Key finding #1: Using a combination of photoconversion and scRNA-seq, we show that conventional NK cells rapidly adapt their transcriptome following entry into the tumour, establishing a distinct tumour-retained/resident state in only 48-72 hrs. See Fig 1.
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2 of 5.Building on the approaches published last year (, here we have interrogated what happens to NK cells after tumor entry and for the first time provide a real-time map of their progression to a dysfunctional state.
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1 of 5. We are pleased to present our latest study using our dynamic tumour-labelling models:
biorxiv.org
Immune cell dysfunction within the tumor microenvironment undermines the control of cancer progression. NK cells play critical roles in limiting early tumor growth and metastatic disease, however,...
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We have a post-doc position available focused on intestinal and cancer immunology. Ideal for PhD students soon to submit, who want to work with some cool in vivo models to better understand immune responses. Position advertised on BSI Jobs Board.
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3 year Post-doctoral position in the Withers Lab at the University of Birmingham.Details: For more information and/or informal discussions regarding the post, please contact: d.withers@bham.ac.uk.
edzz.fa.em3.oraclecloud.com
This is an exciting opportunity to investigate the regualtion of anti-tumour responses in vivo and how these can be enhancd through immunotherapies. The Withers Lab has pioneered a number of unique...
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RT @DKFZImmunology: We are thrilled to announce the speaker of our next i3 @DKFZ seminar: on November 14th at 4 pm we'll have the honour to….
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RT @ZhiLiImmunology: Pleased to see our paper "Photoconvertible tumors to track T cell dynamics" with my former lab @LabWithers is featured….
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RT @RidingAlex: So great to see this finally out!! Top team @ClatworthyLab @loudon_kevin @KelvinTuong @drbstewart @iScience_CP . https://t.….
cell.com
Immunology; Cell biology; Transcriptomics
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RT @theRAD__lab: Very excited to share our new work explaining how #antibiotics can lead to life-threatening fungal infections, out today i….
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RT @ColinYCLee: Pleased to have my first publication with @ClatworthyLab out & hopefully many more to come! Read our work in @FrontImmunol….
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RT @JExpMed: .@ZhiLiImmunology @KelvinTuong @IWD_Sci et al use photoconversion to temporally label tumor-infiltrating lymphocytes, revealin….
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Many congratulations @ZhiLiImmunology, @KelvinTuong, and @IWD_Sci on our first (of many 🤞) tumour immunology research outputs.
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Collectively, our data reveal new insight into the dynamic nature of different CD8 T cell subsets within tumours. Huge thanks to all collaborators and funders of this project @wellcometrust @CancerResearch @WorldwideCancer @AstraZeneca 8/8
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Finally, we asked determined that blocking PD-L1 resulted in reinvigoration of retained exhausted cells as well as the enhanced responsiveness of newly recruited CD8 T cells upon entering the TME. 7/8
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We further discovered that the absence of TCF-1+ PD-1+ CD8 T cells from the tumour resident population was explained by their egress back to lymphoid tissues. Thus the stem-lie niche appears highly dynamic, balancing constant recruitment with escape from the TME. 6/8
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