Mihalis Lionakis
@LionakisLab
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Physician-scientist #NIAID @NIH | #Immunology | #innate immunity | #Immunodeficiency | #Fungi | #Infection | Father | π¬π·πΊπΈ | Views are mine, not of US govt
Bethesda, MD, USA
Joined January 2021
Great work, Kathleen! Many congratulations!
A million thanks to @tmhohl71, the whole Hohl lab π, @LionakisLab, Amariliz Rivera's group @RutgersU, @WCM_IMP, and the folks @SciImmunology. If you'd like to read the paper π° and don't have access for any reason, I'm happy to send a copy, just let me know. End thread βΊοΈ
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A great lab to train! Amazing science, great mentoring!
Interested in immunology and looking to gain research experience before applying to graduate or medical school?Join us! We're hiring a research technician
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@NIH experts from the @NIAIDNews , @NIDDKgov ), and @theNCI discuss the case of a young girl with severe multi-organ autoimmunity, highlighting the role of excess IFN-gamma in APS-1/APECED. Watch the full lecture: https://t.co/xNLjLPlq0W
#ClinicalCenterGrandRounds #Autoimmunity
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π. π’πΆπ³πͺπ΄, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health care facilities. Full review with interactive map: https://t.co/nlzcy2bmMY
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Fun to write this review on Candida auris infections @NEJM with @AnuradhaMyco! Thanks Anu! https://t.co/Qu0MURKitc
nejm.org
C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health c...
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Our recent study out today in @PLOSPathogens identified cell type specific immune responses to Candida auris skin infection using single cell transcriptomics. Thank you @LionakisLab, Mihai Netea and Vinod for collaborating in this study ! https://t.co/RHv2n3ZK9J
journals.plos.org
Author summary C. auris, an emerging fungal pathogen, preferentially colonizes human skin and causes outbreaks of systemic infections. However, the factors that regulate the pathogenesis of C. auris...
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Thanks @NIAIDNews for highlighting our work!
The #NIAID-led discovery of a gene variant causing some cases of #APECED, a deadly inherited #RareDisease, will facilitate earlier diagnosis and medical care that may prolong lives and has led to the design of a potential treatment: https://t.co/GpNWVe6Ivt
#NIH π· Credit: NHGRI
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The #NIAID-led discovery of a gene variant causing some cases of #APECED, a deadly inherited #RareDisease, will facilitate earlier diagnosis and medical care that may prolong lives and has led to the design of a potential treatment: https://t.co/GpNWVe6Ivt
#NIH π· Credit: NHGRI
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Our synthesis of the genetics, immunopathogenesis, diagnosis, and treatment of inborn errors of immunity that impair thymic development and/or function. With Francesca Pala and Gigi Notarangelo @jacionline
https://t.co/pKIXD0EmOR
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Candida auris Skin tropism Drug resistance Challenging infection control Persistence at hight temperatures and high saline condition #IDWeek2024 Dr. Lionakis
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We are recruiting! A PhD position is available @LabLeibundgut on Malassezia-host interactions. We are looking for highly motivated, creative and dedicated team player. Please apply before 1st November via our PhD program @MimZurich at https://t.co/Bpu3Z0BOpn
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Host-microbe interaction paradigms in acute &recurrent vulvovaginal candidiasis @jessiemacalpine @LionakisLab review host, microbiome &fungal factors that alter susceptibility to vaginal yeast infections & highlight progress in antifungals & vaccination https://t.co/rrrVPG9XF1
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Reviews on Fungi Host-microbe interaction paradigms in acute & recurrent vulvovaginal candidiasis https://t.co/rrrVPG9XF1 Intestinal fungal-host interactions in promoting &maintaining health https://t.co/yGXWCI9PJE Immunity to fungi &vaccine considerations https://t.co/34ZuauQLl8
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A synthesis of our current understanding of host-fungal interactions in vaginal candidiasis, the most common human fungal infection. By @jessiemacalpine, way to start your fellowship at @NIAIDNews Jessie! @cellhostmicrobe
https://t.co/anpX1mYD7j
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An honor to write a @J_Immunol Pillars piece for @slg1717 and H.Conti groundbreaking work @JExpMed on IL-17 promoting mucosal fungal defense. A rare example of basic research that faithfully translates to humans and will undoubtedly stand the test of time!
pubmed.ncbi.nlm.nih.gov
This Pillars of Immunology article is a commentary on "Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis," a pivotal article written by H. R....
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Last call: ID Service @MSKCancerCenter is hiring a clinician. Interest in stewardship a plus, not required. Apply via: https://t.co/uGZql54JrN Include CV, cover letter, career statement, and contact info for 3 references. Applications reviewed as they come in through October.
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Focus on Fungi: from infections to immunity, inflammation, mycobiota, and AMR with the amazing @slg1717 @gordon_d_brown @DukeHeitman @LionakisLab, Bruce Klein, Petra Bacher. #FungaWeek24 @Cell
cell.com
Fungi play critical roles in the homeostasis of ecosystems globally and have emerged as significant causes of an expanding repertoire of devastating diseases in plants, animals, and humans. In this...
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3/3 an antisense oligonucleotide could restore normal AIRE splicing in vitro, pointing to a potential treatment approach for these patients (currently being tested in a new KI mouse model with this variant). Thanks to all referring physicians and to collaborators @AfzaliBehdad
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2/3 Founder variant in Puerto Rico, also found in Spain and in a US patient without Puerto Rican or Spanish ancestry; thus, likely to be enriched in other Hispanic APECED cohorts and also sporadically in US patients. Important to incorporate into existing genetic panels for IEI
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