Benjamin Stewart
@drbstewart
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#singlecell #genomics 👨💻 🧬 | #kidneys 👨⚕️🏥
Cambridge, UK
Joined June 2014
RT @SherwoodLab: (1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin access….
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V promising approach perturb multiome - effects of tf perturbations on chromatin accessibility and expression
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🫠🫣.
The last revision experiment
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RT @jrmmhughes: Great collaboration between the @FoldingGenome and Watkins labs, reporting the first Gain of Function de novo enhancer caus….
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RT @ItaiYanai: Every project is unique – like a ❄️– but after experiencing many projects it also gets pretty clear that there is pretty muc….
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underrated tweet.
I reckon that for every Olympic sport there should be two control lanes: .- one with a regular person off the street (negative control) .- one with a fully doped professional athlete (positive control).
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Very cool ancient genomics.
It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago. 🦣💨 .Don’t miss our thread below! 🧵👇🏽
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Congratulations Asger .This is very interesting and important work!.
Mutant HSCs in human clonal haematopoiesis have an attenuated response to inflammation and ageing, which may give them a selective advantage. Happy to share our new paper published in @CellStemCell:. A thread below…./1.
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amazing!.
A first at Northwestern Medicine! Go inside the operating room and witness surgeons performing a #KidneyTransplant on a patient who was awake for the entire procedure. @NM_Transplant #NMBetter
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A privilege and honour to receive the Raine award and I hugely enjoyed sharing our science at #UKKW2024.
Dame June Raine DBE, CEO of @MHRAgovuk presents @drbstewart with this years Raine Award (in memory of Tony Raine & awarded for significant contributions to renal research) at #UKKW2024 science session after the talk "Mapping immunity in the human kidney with single cell genomics"
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Making protein sequencing a nucleic acid sequencing problem seems to be the way this will be cracked.
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Edman degradation strikes again.
We are excited to share our latest preprint on a new solution to next-generation peptide/protein sequencing. Peptide sequencing via reverse translation of peptides into DNA
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this is a very interesting sequence-function association for the small number of enhancers that operate a large distances. Curious principle for gene regulation -.
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: 1/
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Please just let the poor patients sleep.
To preround or not to preround (in person) for trainees?. I’m in the ‘let patients sleep, chart review preround, and patient centered rounds later’ camp. What about you?
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ribosomal DNA copy number variation as a potential genetic influence on CKD risk. Associates with creatinine, cystatin C, urea, microalbuminuria.'kidney failure' rather than glomerular disease or urolithiasis. what does rDNA copy number do to the kidney?
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It was a super cool pre-print. Now it's a super cool @Nature paper. Really innovative work.The UMAP police are coming for Fig2c/d though. .
GoT-ChA! . I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in @Nature !!. 👩🔬👨🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples:. 👇🧵.
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interesting clinical pearl on very very commonly prescribed drug.
1/15.Why are statins administered at night? . In this tweetorial I'll discuss the mechanistic and historical reasons for the frequently used QHS dosing schedule. And why it's often unnecessary. But before we get there, I'm curious: when do you prescribe/order/take statins?.
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