Jigar V Desai
@jigarvdesai
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Immunologist, fungal geneticist, microscopist | Investigator at the Center for Discovery & Innovation, Hackensack Meridian Health
Nutley, NJ
Joined April 2011
Thrilled to share the results of our 8-year-long expedition into the Wild, the city of #NYC , the wild west of #LosAngelesCA , and more—in search of the roots of gut fungal commensalism! 🧵 https://t.co/P4vv7Ll9dp
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Our recent study out today in @PLOSPathogens identified cell type specific immune responses to Candida auris skin infection using single cell transcriptomics. Thank you @LionakisLab, Mihai Netea and Vinod for collaborating in this study ! https://t.co/RHv2n3ZK9J
journals.plos.org
Author summary C. auris, an emerging fungal pathogen, preferentially colonizes human skin and causes outbreaks of systemic infections. However, the factors that regulate the pathogenesis of C. auris...
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Fun to write this review on Candida auris infections @NEJM with @AnuradhaMyco! Thanks Anu! https://t.co/Qu0MURKitc
nejm.org
C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health c...
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Thanks @NIAIDNews for highlighting our work!
The #NIAID-led discovery of a gene variant causing some cases of #APECED, a deadly inherited #RareDisease, will facilitate earlier diagnosis and medical care that may prolong lives and has led to the design of a potential treatment: https://t.co/GpNWVe6Ivt
#NIH 📷 Credit: NHGRI
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Excited to share results of our fun collaboration with Neeraj Chauhan and Anuradha Chaudhary; led by the talented research associate Raju in the lab, where we describe roles for a Candida auris MAP kinase in skin colonization |
journals.asm.org
Candida auris is a World Health Organization fungal priority pathogen and an urgent public health threat recognized by the Centers for Disease Control and Prevention. C. auris has a unique ability to...
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We are recruiting! A PhD position is available @LabLeibundgut on Malassezia-host interactions. We are looking for highly motivated, creative and dedicated team player. Please apply before 1st November via our PhD program @MimZurich at https://t.co/Bpu3Z0BOpn
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My lab has an opening for a Postdoctoral Research fellow. If you are interested in Candida auris pathogenesis and translational research, apply: @HarborUCLA_ID , @the_lundquist More information:
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The abstract deadline for the GRC Immunology of Fungal Infections with @tmhohl71 @theRAD_lab @UMOWheelerLab @LabLeibundgut is approaching! Submit your abstract by 13th October via
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Focus on Fungi: from infections to immunity, inflammation, mycobiota, and AMR with the amazing @slg1717 @gordon_d_brown @DukeHeitman @LionakisLab, Bruce Klein, Petra Bacher. #FungaWeek24 @Cell
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1/3 Excited to share our new paper led by Sebastian Ochoa & @ChasenLouie at @ScienceTM in which we found a deep intronic AIRE variant that causes inclusion of a frame-shifting pseudoexon that impairs AIRE function and explains APECED in ~15% of our cohort
science.org
An extrathymic AIRE expression system uncovered a deep intronic AIRE variant that causes APECED and can be targeted with antisense oligonucleotides.
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Check out our new preprint "Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance". Thanks to my collaborators @LionakisLab @slg1717 @Jendzjowsky #Filler-lab https://t.co/X9vsLAdDcP
biorxiv.org
Mucosal barrier integrity is vital for homeostasis with commensal organisms while preventing pathogen invasion. We unexpectedly found that fungal-induced immunosurveillance enhances resistance to...
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We are recruiting a new faculty member for our Division at Harbor-UCLA 👇 https://t.co/qdv3XfVC0a
asmcareerconnections.org
A new
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🆕 Interplay btw host humoral pattern recognition molecules controls undue immune responses against #Aspergillus fumigatus in @NatureComms w/ @VAimanianda at @institutpasteur 👉 In long : https://t.co/MGcQcHkHbR 👇 In short 🧵 1/6 #pentraxin3 #immunity
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Thrilled to be awarded this exciting 8 year grant with @BECKS_182 to better understand fungal adaptation to the host. Post doc positions soon available - please get in touch if you're interested in working with us on organ specific phenotypes and immunity!
Happy to share that I have been awarded an 8-year @wellcometrust discovery award together with @theRAD_lab to identify new fungal innate immune evasion strategies. Positions at @biokent and @unibirmingham to be announced soon. Get in touch for more information.
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Congrats to the Klein lab @UWMadison on their wonderful work on white-nose syndrome https://t.co/j7Um8iE936
science.org
Millions of hibernating bats across North America have died from white-nose syndrome (WNS), an emerging disease caused by a psychrophilic (cold-loving) fungus, Pseudogymnoascus destructans, that...
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Thanks @NIAIDNews for highlighting our work. @jigarvdesai @marissazar Andrew Wishart. @tmhohl71 @RoschewskiMD
#NIAID scientists learned that people receiving a certain class of #cancer treatments develop fungal infections because the drugs block a pathway that leads to #antifungal immunity. The scientists say this work may lead to improved cancer care: https://t.co/KVH0kZX39J Image: CDC
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BTK drives neutrophil activation for sterilizing antifungal immunity: https://t.co/2hpG0MPxtV
@LionakisLab @NIAIDNews @NIH
#Immunology #InfectiousDisease
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Great overview of the mucosal complement by @kulkarnilab . Local complement activation and modulation in mucosal immunity
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@NEJM @LionakisLab Brilliant & seminal study that redefines the pathophysiology of APECED. By understanding the basis of fungal disease susceptibility @LionakisLab found the true culprit - IFN-gamma - that underlies autoimmunity in these patients. A triumph of grit and perseverance. Chapeau!!
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