Interfacial Cell Biology
@KnorrLab
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Biology mixed with physics & curiosity @UniCologne. Membranes, wetting, LLPS & condensates. Autophagy. Grow, microscope, eat plants. Harassment-free science.
Berlin and Köln
Joined August 2021
Thanks for everyone contributing!
Condensates can not only bend biomembranes, but also cut them (fission). Check out the first evidence in our @nature paper: https://t.co/ZUBpp3tKuJ Great collaboration between maths, physics and biology @AgudoCanalejo @XiaofengFangLab @KnorrLab @csbdresden
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We are hiring a PhD @EdinburghUni @SchoolOfEng_UoE to work on the bottom-up design and construction of synthetic cells using #microfluidics and #lipid membranes. Lab is based at the Institute for Bioengineering. #synbio
https://t.co/dGtdjz8HF0 Please RT!
eng.ed.ac.uk
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We have a PhD position available to study neuronal functions of autophagy and endocytosis.
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#Job alert! A #postdoc position in my lab @CECAD_ @UniCologne is open until December 1st. We look for: enthusiasm, curiosity, scientific rigour, and a background in protein quality control, lysosome signalling, or the cell cycle. We offer: fully funded position, top European
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Thanks to the team and for funds: @SPP2191 @dfg_public! Cell membranes shaped and cut by phase-separated liquid protein condensates https://t.co/y6dBw3ggYO
@Pha_Tran_Papers
nature.com
Nature - Membrane bending and cutting can be mediated by biomolecular condensates, as well as by the conventional protein machinery.
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We simulated the formation of OPTN droplets on the membrane in mitophagy. The droplets could lead to the membrane connection. Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates | The EMBO Journal
embopress.org
imageimageAutophagy adaptors undergo liquid-liquid phase separation, but it remains unclear how this contributes to selective mitochondrial autophagy. This study shows that the mitophagy adaptors...
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Exciting news: 2D condensates at mitochondria! Thanks to @yj_sakai, @ChinoHaruka, @MizLabUT. Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates | The EMBO Journal https://t.co/HpuyxEKfsX
@Pha_Tran_Papers
embopress.org
imageimageAutophagy adaptors undergo liquid-liquid phase separation, but it remains unclear how this contributes to selective mitochondrial autophagy. This study shows that the mitophagy adaptors...
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💧✂️Liquid droplets cut membranes without protein scissors🌱 A study led by @knorrlab and team shows that tiny liquid droplets, known as biomolecular condensates, cut membranes of plant cells without the need for specialized protein✂️ Read more 🔗 https://t.co/J4F9NDKNg0
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✂️A *liquid* pair of scissors? This is DALL-E's representation... But biology has built the real deal, as our new work w/ @XiaofengFangLab @KnorrLab @aland_lab just out @Nature shows https://t.co/dpftNibSEA (1/6)
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Not exactly X-less
more from Knorr! congrats twitterless Roland and @XiaofengFangLab condensates 🤝 membranes 🤝 plants https://t.co/Ht9rFGnohn
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In intracellular trafficking, the ESCRT machinery mediates membrane scission of the multivesicular bodies (MVBs). Work @nature proposes that, in plant cells, this is mediated by biomolecular condensates, and depends on the condensates' physical properties. https://t.co/QFmazk5p4r
nature.com
Nature - Plant ESCRT component FREE1 forms liquid-like condensates that associate with membranes to drive intraluminal vesicle formation.
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We are thrilled to welcome our new colleague Roland Knorr with his team @KnorrLab who just was appointed as W2 professor @BCCologne @UniCologne @UKKoeln We are looking forward to exciting research on phase separation & shaping of biological membranes https://t.co/ASrUJfmoz4
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Exciting news: our lab expands and moves @UniCologne next to @CECAD_ ; thrilling papers will be out soon...
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Looking to join our lab in #berlin? We're hiring! #microscopy #imaging #biology #physics #biophysics #biochemistry #cellBiology #Bioengineering
#phdstudent #studentships #PhDposition #postdoctoral #Postdocposition #sciencejobs #postdoc
@BioCondensates @dfg_public @HumboldtUni
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❗️just out @PhysRevLett ❗️a surprising nonequilibrium effect hidden in a classic theory of phase separation...
It turns out that enzymes can drive liquid-liquid phase separation without equilibrium interactions! In a new paper with @AgudoCanalejo and @RGolestanian, we show how this can happen and how it can automatically regulate the enzymes' activity. https://t.co/YyCShoOqrl
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Our new preprint is out! The standard shapes of phagophores during autophagosome formation are statistically determined by 3d-EM and are quantitatively explained by a physical model. Congratulations, Yuji!! https://t.co/i5LW9DyjIg
biorxiv.org
Autophagy is an intracellular degradation process mediated by autophagosomes. The formation of autophagosomes involves dynamic morphological changes of the precursor phagophore, in which a disk-sha...
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"We can't change our city. We are not Amsterdam!" #Vienna: 'hold my #Weisswein🥂*' - Königsegggasse (*or 16er-Blech🥫 if you prefer)
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Impressionnantes IMAGES de l'effondrement d'un pan du glacier de la #Marmolada, dans les Dolomites, sur la voie qui mène au sommet de la Punta Rocca. Il y faisait 10°C (très chaud donc). Il y aurait au minimum 5 morts et 8 blessés. #UrgenceClimatique
https://t.co/D7roYW1dBD
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