
Sam Klempner
@KlempnerSam
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GI medical oncologist focusing on stomach and esophageal cancer research at Massachusetts General Hospital, Harvard Medical School
Boston, MA
Joined January 2019
Check out our deep dive in MSI-H gastric cancer, now out in @CD_AACR . Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability-High Gastric Cancer
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RT @ArndtVogel: Givastomig, a novel claudin 18.2/4-1BB bispecific antibody, in combination with nivolumab and mFOLFOX in mGEC.🔎Phase I/II.👉….
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RT @SunnieSKim: FORTITUDE 101 is a positive Phase 3 study in FGFR2b overexpresssed gastroesophageal cancers! Looking forward to seeing the….
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RT @FASinicropeMD: Enjoying interacting with other speakers and discussants during today’s plenary. Exciting new data was presented. https….
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RT @ElizSMcKenna: Attending the #AACR25 session on Innovative Paradigms in Immunotherapy Combos in Gastric Cancer? Read speaker @KlempnerSa….
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Adding some spatial omics to HER2+ gastric cancer. Determinants of Response to Sequential Pembrolizumab with Trastuzumab Plus Platinum/5FU in HER2-positive Gastric Cancer: A Phase II Trial. @JeeyunM @AnMinae @arnavmehta3 @CCR_AACR.
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Proof of principle in KRAS G12C CRC, analogous to EGFR rechallenge in RAS WT Colon cancer. @MGHCancerCenter @JCOPO_ASCO . Anti-KRAS G12C + Anti-EGFR Rechallenge in Chemotherapy-Refractory KRAS G12C–Mutated Colorectal Cancer.
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Cool paper from @ShadiEsfahani and team in @ScienceTM @MGHCancerCenter . Development of a fibrin-targeted theranostic for gastric cancer | Science Translational Medicine
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RT @SCIDirector: SCI members @HowardYChang, @mischellab, and others found that blocking #CHK1 activity leads to death of #ecDNA containing….
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Great to have another option for patients. @KoheiShitara @mdmanishshah @ILSONDavid @FlorianLordick @sara_lonardi1 and many others. FDA Approves Zolbetuximab Plus Chemo for CLDN18.2+ Gastric or GEJ Adenocarcinoma via @onclive.
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RT @KoheiShitara: Pleased to share final survival results of two phase 3 of zolbetuximab @NEJM which reinforce zolbetuxumab plus chemo as….
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RT @sundar__raghav: Building one of the largest datasets of gastric cancer peritoneal metastases in the world, we unravel new biology of or….
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Congratulations to Harsh Singh and @DanaFarber team for getting this data out. CAPOX + Trastuzumab + Bevacizumab in frontline HER2+ gastroesophageal. @NatureComms @JamesClearyMD @DrRonanKelly and others . -- full paper.
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RT @KEN_K_: I am pleased to inform you that the primary result of JCOG1109 was published in the Lancet today. The neoadjuvant triplet chemo….
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RT @ElizSMcKenna: The June issue of @CD_AACR is online! On the cover: Efficacy and Safety of Adagrasib + Cetuximab in Patients w/#KRAS G12C….
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RT @MyriamChalabi: #ASCO24 plenary: ESOPEC 👏👏.👉🏼neoadj CROSS vs peri-op FLOT in pts with EAC.👉🏼221 in FLOT vs 217 CROSS arm.👉🏼 Median OS: 6….
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RT @JCOPO_ASCO: ‼️ #ASCO24 simultaneous publication by @KlempnerSam et al: . PD-L1 Immunohistochemistry in Gastric Cancer: Comparison of Co….
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RT @CD_AACR: New from the May issue—.Sequential chemoimmunotherapy in #gastriccancer, by @AnMinae, @arnavmehta3, Byung Hoon Min, You Jeong….
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