Kevin Goeij
@KevinGoeij
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PhD Student @Cambridge_Uni | MRC LMB – Holliger Lab | Alum @UniofOxford | Selective agent of RNA self-replicators | Understanding life and time 🌱
Cambridge, UK
Joined January 2014
Led by @edo_gia. Congratulations to everyone who contributed to the work! More to come. (6/6) Publication link:
science.org
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural...
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This discovery challenges our current understanding of the minimum sequence requirements for the emergence of such a complex ribozyme phenotype, a key enabling feature of RNA self-replication in the context of the origin of life. (5/6)
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We demonstrated that such a small motif is capable of undergoing templated polymerisation of sequences longer than itself, functional ribozymes, its complementary strand, and itself, with modest fidelity. (4/6)
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It was selected from an N40 random sequence library (starting pool of ~6 × 10¹² sequences), with a sequence-general and regiospecific 3′,5′-phosphodiester bond formation activity. (3/6)
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QT (‘Quite Tiny’) 45 is a small polymerase ribozyme capable of synthesising itself and its complementary strand using triphosphorylated trinucleotides in the eutectic phase of water ice. (2/6)
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A major work from our lab is out in Science! @ScienceMag, another key step towards a true demonstration of RNA self-replication. https://t.co/2Fe8XonYst (1/6)
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Told yaa 👽🧬
While ribose was present, deoxyribose (the DNA sugar) was not. This suggests RNA may have been more prevalent than DNA in the early solar system – supporting the “RNA world” hypothesis that DNA was not necessary for the origin of life.
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Allow me to articulate this explicitly Only ribose (the RNA sugar), but not 2'-deoxyribose (the DNA sugar), was detected. :)
Scientists identified ribose (used in RNA) and – for the first time in any extraterrestrial sample – glucose, a major energy source for life. These sugars join nucleobases and phosphates previously found, demonstrating the full suite of RNA building blocks were present on the
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I’m endlessly amazed by how often symmetry emerges in the functional parts of nature
Studying retinal morphogenesis in the developing eye of fruit flies, researchers in Science identified spontaneous calcium waves originating from non-neuronal cells responsible for orchestrating tissue architecture in the developing nervous system. 📄: https://t.co/NrrWQ2JBAF
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the more water, the merrier 🌊🦠
A reaction between hydrogen and magma at high pressure can produce water, which might explain evidence for ‘wet planets’ in places where water can’t condense https://t.co/zjntuqiPGe
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How ur email finds me btw
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Why fundamental research is fundamental to progress, seeding major breakthroughs Editorial @Nature this week And 7 basic science discoveries that changed the world https://t.co/0YrKabc7ff
https://t.co/SM11QSJhWz
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The scientific community has lost another giant; John’s legacy will endure, and his memory will continue to inspire generations of scientists to come.
nytimes.com
His work in the manipulation of cells laid the foundation for stem cell biology and regenerative medicine and led to the first cloned large mammal, a sheep named Dolly.
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Biology has always been engineering for those with the eyes to see
Biology is turning into engineering
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For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began https://t.co/HymCZx92ki
nature.com
Nature - Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.
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Come and join us in pushing the frontiers of science.
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( https://t.co/dBGYKz5u7O ) at the MRC Laboratory of Molecular Biology (LMB)
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campbell biology 12th edition
can someone recommend a good book? thanks
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You can have a vacation with any 3 people in history, dead or alive who are you choosing?
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