Thank you to Katy Wellen and @MarmorsteinLab for input on countless drafts of this work!

Bempedoic acid (Nexletol) is a non-statin ACLY inhibitor 💊 that is FDA-approved to lower cholesterol 🩸 and reduce cardiac risk 🫀. But could it have clinically relevant targets in addition to ACLY? 🤔 Learn more in our recent review:

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on

#StandUpForScience in Philadelphia!!

Penn to reduce graduate admissions, rescind acceptances amid federal research funding cuts

Finally, someone is reporting on how funding of new NIH grants is effectively frozen due to an administrative block 👇 Grants already submitted cannot be reviewed, and grants already reviewed with excellent scores cannot be funded. This is the opposite of "efficiency".

Tomorrow, 42 million Americans might not be able to buy food after Trump shuts down SNAP payments at 5:00 p.m. Students will have to drop out of college if they don't get their student loans.

Wadman and Kaiser are on it, over at ScienceInsider at the glam mag Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring | Science | AAAS

Trump blocks NIH review. I’m on a study section to review cancer grants but received this email today: NIH has paused all communication, as directed by the new administration (e.g. https://t.co/KD9vnuN3ac  ), and that apparently includes a pause for all study section meetings

NIH withdrew several funding opportunities related to diversity. They’re not going to review the ones already in, and apparently they’re not going to pay the ones that have just been awarded.

Guys…this is not a drill

America leaving the WHO is a mistake. When it comes to pandemics, no one is safe until everyone is safe. https://t.co/09ZClEkZB7

🚨Apparently all NIH Study Sections have been suspended indefinitely. For those who don’t know, this means there won’t be any review of grants submitted to NIH Depending on how long this goes on for, this could lead to an interruption in billions in research funding.

DEI programs were created to give everyone who meet objective standards a fair shot at serving our country. Diversity has changed America for the BETTER. Rolling back these programs and offices with an executive order is completely disgraceful. https://t.co/Te56GS379c

Monstro Amerisue

Phantom Metabolites @ScienceMagazine and their take on our recent @NatMetabolism https://t.co/sAebndpuQH paper https://t.co/84ia3ocaNR

Happy to report that our paper, where we grapple with the mystery of ACLY splice isoforms, is finally out! https://t.co/SLGy7jG4QO @WellenLab @MarmorsteinLab

Proud to join faculty and elected officials across the city demanding that Penn not arrest or discipline peaceful protestors for Palestinian liberation. We are grateful for the students’ leadership and urge our universities, and our city, to hear their call.