Jarrett Renn Remsberg
@JarrettRenn
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Everything chemoproteomics and drug discovery @Belharra Tx. Former American Cancer Society Fellow @scrippsresearch, ChemE @MIT
Joined November 2020
Brilliant work! Very excited to see where this takes the field. Kudos to those who designed the screen, such an amazing and simple idea in hindsight (those are typically the best!).
I am very enthusiastic for improving fragmentation spectra & the research this empowers. This means increasing the sensitive and scope of sequencing the immunopeptidome ==> better cell therapies. 1/2
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RT @kdonovan1008: Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin….
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RT @wgibson: Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber!. If you are a trainee intere….
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Great visualization and reminder of timescales for biological processes. I remember first seeing something like this in @UriAlonWeizmann's System Biology textbook (which was formative in my decision to move into biophysics for grad school).
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Stacked lineup of heavy weights in the field, looks to be a great conference!.
Registrations are now open for the 14th ABPP conference @abpp2025london on March 30th to April 2nd, 2025, at the Francis Crick Institute. An amazing lineup of speakers. Very much looking forward to catching up with everyone.
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Super cool work from the @Michael_A_Erb lab! I had the pleasure to hear it recently and excited to see it out now. Molecular glues and SuFEx chemistry make for a great story!.
We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues.
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Great review for anyone interested in chemoproteomics and drug discovery! Proud to have been part of many of these stories and discoveries during my time in the Cravatt lab and excited for what's to come!.
Excited to share this @CellChemBiol Review I wrote with Ben Cravatt highlighting recent applications of ABPP for ligand discovery. We highlight the expansion of ABPP beyond enzyme active sites with a special focus on covalent ligands. Enjoy!
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Excited to be presenting later this morning at the #DrugDiscoveryChemistry conference here in San Diego! Come hear about our work from the Cravatt lab deploying a function-first strategy investigating PPIs to expand the druggable proteome!.
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Very proud of @liu_zhonglin for this fantastic work! Multiple ligands on the same site with disparate results?! and stereoselective ligand-induced degradation!.
Excited to share my postdoctoral work in the Cravatt lab. We described a set of stereo- and regiochemically defined spirocycle acrylamides and their chemical proteomic analysis in human cancer cells, leading to the discovery of ERCC3 degraders and other novel ligands.
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So excited to share this story. See @Michael_A_Erb's thread hitting all the highlights (chemoproteomics meet FOXA1 and chromatin biology!). This was a fantastic collaboration and congrats to everyone!.
Together with the Cravatt group, we have a new manuscript out reporting the chemoproteomic discovery of covalent FOXA1 ligands that bind its DNA-binding domain, corrupt its motif preferences, and redistribute it on the genome. 1/11
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Really a tour de force here and so happy to see this body of work out!.
Excited to share my postdoc work in Cravatt lab & Schreiber lab!.We described photo-stereoprobes, DOS-inspired photo-reactive probes, for expanding the ligandable proteome. 🧵.
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RT @armandcognetta: I'm hiring a principal scientist/director at @proxbio to take over my role of leading the absolutely stellar group of s….
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For those attending US HUPO and interested in chemoproteomics, this short course is a must!.
Explore Chemoproteomics 101 at #USHUPO2024! Unveil chemical biology + proteomics, understanding how probes impact biology. Learn methodologies, applications, and the expanding "druggable proteome":
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RT @mads_chem: Interested in #chemicalproteomics and developing #chemicalprobes with unique mechanisms of action? Funded #PhDposition @UniL….
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RT @YuanjinZhang1: Excited to share a major part of my thesis work in the Cravatt Lab! In collaboration with Pfizer, we present a "paralog-….
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RT @DanNomura: Cool paper from Cravatt lab on Expanding the ligandable proteome by paralog hopping with covalent probes! .
biorxiv.org
More than half of the ∼20,000 protein-encoding human genes have at least one paralog. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to a subset of...
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RT @_chrisgparker_: Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determi….
nature.com
Nature Chemical Biology - A chemoproteomic workflow was developed to determine the interaction sites of photoaffinity probes in cells, enabling the identification of diverse binding pockets and...
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RT @lwelmore0320: Great news: 131 new @ACS_Research grants totaling $64.5M have been funded. That’s a whole lot of innovation and hope! Con….
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RT @_chrisgparker_: Excited for Belharra and its recognition - congratulations to the whole team!!.
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RT @JProteomeRes: Most Read in the past 30 days! Check it out: "Sage: An Open-Source Tool for Fast Proteomics Searching and Quantification….
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