Thrilled to present our unpublished work on how dendritic cells decode LNP-embedded antigenic cargo at the @ESGCT meeting in Rome (bit overwhelmed by the amount of people though😱). For all DC and LNP lovers, come find me at 15h3O in Parallel session B.

Very happy that our review in Nat Rev Imm is out! Trying to shed some light on the many knowns and even more unknowns of homeostatic dendritic cell maturation with @Victor_Bosteels @InflamResCen.

Interested in dendritic cell biology and/or IRE1 signaling? Ready for a new challenge in the city of Ghent? If the answer is 2x yes, please check the VIB website for open positions for a PhD student and a postdoc in the @JanssensLab

So now we finally know why IRE1β behaves as it does: it just needs its partner in crime, AGR2, to calm down.

AGR2 is a pretty interesting protein, especially upon mutation of H117 to Y: this causes massive inflammatory phenotypes in patients. Turns out that the H117Y mutant is also completely incapable of blocking IRE1β activity!

Now how does AGR2 do this? Well, simply by driving IRE1β monomerization. And as we all know: no dimers or oligomers equals no activity for IRE1 proteins.

Remember how IRE1β appeared to be a killing machine when it was first characterized in epithelial cells? Well, it was time to find it’s regulatory interaction partners. AGR2, a small goblet cell chaperone, was a top interactor and AGR2 completely blocked IRE1β activity/toxicity.

Great job by @ClootsEva and Phaedra from the Janssens lab! Happy to see their work out in @embojournal. A fun and collaborative effort with @VIBEyckermanS and @SavvidesLab. @VIBLifeSciences @InflamResCen. Time for a thread!.

Very proud PI with a fantastic PhD defense of @Victor_Bosteels @InflamResCen. Thanks at Caetano @ReiseSousaLab and Fabiola @Fbosorioo for coming all the way from London and Chile to join us. All the best to Victor for his new adventures in @bart_lambrecht and @ReiseSousaLab!

Thanks to @VIBLifeSciences, @InflamResCen and @FWOVlaanderen for their continued support.

Very happy to share our preprint on the discovery on the mucus chaperone AGR2 as a regulator of the goblet cell stress sensor IRE1b! Fantastic job done by @ClootsEva in collaboration with the @VIBEyckermanS Lab. Stay tuned for the peer-reviewed paper!.

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

The ever expanding universe of TAOK3…Very proud that this joint study with @bart_lambrecht got published. Big congratulations to @maes_bastiaan and Farzaneh Fayazpour for a massive amount of work!.

Therefore, we would like to express our gratitude to first authors Sofie Rennen and Felipe Flores-Santibanez for their continued effort throughout this long reviewing process. Thanks also to Fabiola Osorio @Fbosorioo for a great collaboration!.

It is always difficult to get negative data published, even though they are solid. Still, we were convinced it was important to convey this message to the scientific community in view of the broad role of the UPR in anti-tumor immunity.

To our surprise, we could not confirm a role for IRE1 in regulating dendritic cell-mediated anti-tumor immunity, and this despite the use of several tumor models, several animal houses and several Cre-lines to excise the gene from DCs.

RT @esegura_lab: Find out why you should eat your broccoli #arylhydrocarbonreceptor .

(12/12) Finally, special thanks to the first authors @Victor_Bosteels and @SandraMarechal2 and all other members of the uSJa Team for a massive amount of work! Stay tuned for the follow-up!.

(11/12) Thanks also to our funding organizations @FWOVlaanderen and @ERC_Research. The work was conducted at @VIBLifeSciences, @InflamResCen and @ResearchUGent.

(10/12) This work was a huge collaborative effort and we would like to thank the many labs that helped us along the way, @VIBFlowCoreGT, @VIBSingleCell , @bruno_de_geest, @Ravi_Research, @bart_lambrecht, @saeyslab, @Le_Goff_ICAN and Doris Hoglinger.