Eva Cloots, PhD
@ClootsEva
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Former academic, now MSL gastroenterology @TakedaPharma Big fan of 😸, 🗻, 🏈, but mostly🥼🧪
Ghent, BE
Joined April 2021
RT @JanssensLab: Interested in dendritic cell biology and/or IRE1 signaling? Ready for a new challenge in the city of Ghent? If the answer….
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Happy to announce that our paper on my favorite UPR protein is out in @embojournal! Big thanks to @VIBEyckermanS and @JanssensLab for supporting me during this journey!. Check out the thread below :).
Great job by @ClootsEva and Phaedra from the Janssens lab! Happy to see their work out in @embojournal. A fun and collaborative effort with @VIBEyckermanS and @SavvidesLab. @VIBLifeSciences @InflamResCen. Time for a thread!.
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Beautiful morning to start our last day of #GESRC. Looking forward to the final days of fascinating talks!
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Happy to share this discovery that has been in the making since my PhD years. Who knew there was a tiny protein out there that can tame IRE1b all along 👌 .Thanks @JanssensLab and @VIBEyckermanS for supporting me on this project!. @FWOVlaanderen @VIBLifeSciences.
Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
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RT @KrisGevaert_VIB: Please help spreading! Looking for a postdoctoral fellow to implement and develop single-cell mass spectrometry-based….
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Really happy to be able to meet with everyone from all VIB centers in person again! And big thanks to @VIBLifeSciences HQ for the inspiring program you assembled :).
Finally we're back together again for an on-site #VIBSeminar22. We missed you all and are glad to see so many of our community together again. We hope you enjoy this edition in Genk!
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My poor colleagues had to listen to me stress out about the FWO grant interview for weeks, so I brought them some breakfast to celebrate it wasn't all for nothing 😏.@JanssensLab @InflamResCen @FWOVlaanderen
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Beyond thrilled to share that I will be digging into the biology of UPR sensor IRE1β for three more years at @InflamResCen @VIBLifeSciences thanks to a postdoctoral fellowship from @FWOVlaanderen. @JanssensLab let's do this! 😁🧬.
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RT @Svennetti: Check out our report on orthogonal proteomics for binders of the lncRNA HOTAIR! Great work by @ldlhaye and his colleagues no….
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RT @KrisGevaert_VIB: Please help spreading! To help coordinating and managing proteome analyses, Ghent-based @VIB_PRC housed in @VIB_CMB is….
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RT @ugent: Veertien #UGent'ers waren dapper genoeg de #ThesisThread uitdaging aan te gaan en legden hun onderzoek uit in een Twitter-draadj….
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RT @KC_DC_01: Looking to start your own lab? Interested in organoids? 🧫🧫@InflamResCen & @VIBLifeSciences has a vacancy for a new PI!! Apply….
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Proud to be part of this organization!.
🎉 Today we celebrate our 25th anniversary! Discover our research, our story, and the origin of impact here 👉
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This shows why IRE1β may be really important in our intestine and why I am so excited to continue my research on IRE1β as post-doc. Stay tuned for more updates on the (not so) Evil Twin!. (16/16).
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Mucus proteins are huge, so they’re really capable of clogging the ER. If the ER is clogged, nothing comes through. This would be problematic in the intestine, as we really need the ER to produce a nice mucus layer to separate pathogens from our intestine. (15/16)
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IRE1β expression is actually much higher in the colon compared to the lung, so right now I am focusing on intestinal IRE1β. From earlier studies we know IRE1β also plays a role in intestinal mucus production, and now I’m trying to fill in the details. (14/16)
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We also noticed that these HDM-challenged mice did not display a protein folding stress signature, which may explain why this IRE1 protein is not involved in this disease model. (13/16).
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So we wondered whether IRE1β is still the big man on the respiratory campus when mice are challenged with HDM. Long story short: no. When mice were genetically engineered to no longer express IRE1β, they still produced mucus plugs after HDM exposure. (12/16)
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