Savvas Savvides Lab
@SavvidesLab
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The Savvides lab @InflamResCen and @ugent employs #IntegrativeStructuralBiology to study proteins pivotal to inflammation, immunity and cancer
IRC-VIB, Ghent, Belgium
Joined March 2023
Please follow us on Bluesky 🦋 @savvideslab.bsky.social
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Improved protein binder design using beta-pairing targeted RFdiffusion 🚀 New preprint from David Baker!🚀 • A breakthrough in protein binder design: this study uses RFdiffusion conditioned to generate binders that form precise beta-strand pairings with polar protein targets,
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Read the preprint https://t.co/Dig84ThK77 describing a milestone in our de novo antibody design efforts. Our pipeline can now design high-affinity and stable antibodies in a single round! Fantastic collaboration with @lab_serrano
@SavvidesLab & Maarten Dewilde @KU_Leuven
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Happy to share the #preprint on #denovo #antibody design in a single round yielding stable Abs with high affinity: https://t.co/uVg3GQF1A6 Grateful to be part of great collaboration efforts betwen @VIB_Switch_Lab @KU_Leuven @CRGenomica @InflamResCen @VIBLifeSciences @ugent
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https://t.co/ffFl2HCYNJ A prodigious effort and interdisciplinary collaborative work by @VIB_Switch_Lab at @VIBLifeSciences @KU_Leuven , @lab_serrano at @CRGenomica, @SavvidesLab at @VIBLifeSciences @InflamResCen @ugent, and Maarten Dewilde Lab @KU_Leuven
biorxiv.org
Developing antibodies is complex and resource-intensive, and methods for designing antibodies targeting specific epitopes are lacking. We introduce a de novo antibody design approach leveraging the...
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Training the next generations of scientists in experimental structural biology. We are grateful to @synchroSOLEIL and @Proxima2A for hosting our Master program in Biochemistry-Biotechnology @ugent for a practical workshop on X-ray crystallography.
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@MSCActions @GoossensLabVIB Bart Ghesquière @jennyrussinova @frbre @lab_marine @RaesLab @jeroenraes @FarrowLab @AgostinisLab @Verstreken_Lab @VanderhaeghenP2 @MancusoRenzo @FendtLab @SavvidesLab @steinaerts @martin_toul @AvilienDard @yongming_luo Kresimir Sola @M4riekeHoekstra Célia Lentini
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Delighted to share our work in @NatureSMB on #structures of IL-12/23 cytokine complexes involving the complete extracellular domains of IL-12 family receptors, jointly celebrating 30 years of IL-12 receptor #immunology and @NatureSMB
https://t.co/4tDz6H5PMH
nature.com
Nature Structural & Molecular Biology - Structures of complete extracellular receptor assemblies mediated by the pro-inflammatory cytokines IL-12 and IL-23 reveal key commonalities and diverse...
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HAPPY 30th BIRTHDAY TO US🎂 First issue of NSMB came out in January 1994. Come celebrate with us 30 years of changes and progress in structural and molecular biology https://t.co/fSXTkQmvuX We are continuing celebrations throughout the year with more content, so stay tuned!
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We just had a very exciting, educational, and interactive symposium on #AI in #StructuralBiology hosted by @VSC_HPC and @FWOVlaanderen…Prediction cannot happen without experiments! #AlphaFold #StructurePrediction #XrayCrystallograpy #CryoEM
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Ex vivo X-ray crystallography meets Immunology inside and outside the box in our latest collaborative work with @bart_lambrecht and colleagues at the @InflamResCen and @ugent
https://t.co/BPvG0vMHco
elifesciences.org
Protein crystallization is a rare event yet Ym1 crystals made from a chitinase-like protein are abundantly found in eosinophilic airway inflammation, where they promote type 2 immunity.
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We are heading with a team of seven to Athens, Greece for a very exciting #cytokines2023
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Big thanks to @synchroSOLEIL & @Proxima2A for giving our @ugent students a memorable visit and an on-site view into both theory & practice in #proteincrystallography! #structuralbiology @LM_UGent
PROXIMA 2 hosted students and tutors from the University of Ghent for practicals, tutorials and lectures covering all the steps in X-ray crystallography - crystallisation, harvesting, data collection, structure determination and Savvas Savvides' most famous crystallography quiz!
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Check out the latest issue of @NatureSMB featuring Tsirigotaki et al. https://t.co/QuzwbXmAov on the Leptin-mediated receptor complex as a cover story and additional coverage via a News & Views article https://t.co/VceTbuu5IB
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Given ISOLDE is a model-fitting tool, it was about time I gave it a way to, you know, actually validate the fit of a model to a map. As such, in consultation with Greg Pintille and Tom Goddard I've implemented the Q-Score algorithm ( https://t.co/tbacFT1AOd) in ChimeraX. (1/2)
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We're thrilled to share that @Savvideslab's mechanistic and #structural studies on newly described #trimerization of #Leptin receptor has been published @NatureSMB today! Many congrats to everyone contributing to this work! @VIBlifesciences
https://t.co/QuzwbXmAov
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