JP Lab
@JPLab_
Followers
694
Following
824
Media
5
Statuses
325
Chromosome Segregation @ Wellcome Centre for Cell Biology @WTcell, Univ of Edinburgh, UK @GeneCenter_LMU, Munich, Germany
Edinburgh & Munich
Joined April 2019
Many thanks to Ryu-Suke Nozawa, Toru Hirota, Lea Dury, Willem Vanderlinden, Christos Spanos, @PaulaSoteloP @likhodeeva_m @mdrwilson @hopfnerlab for their valuable contribution!.
0
1
3
RT @shivaprasad_pv: H4.V is Oryza-specific. It is a gatekeeper to promote deposition of active H4K5Ac during salt stress, a common stress f….
0
4
0
Pleased to share that our CENP-32 story is now published! @JPLab_ , Jun Liao, Erica Davis and Bill Earnshaw labs and several clinicians. Led by Avinash Dharmadhikari (CHLA, UCLA), @Alba_Edinburgh and Sheraz Khan. @SBSatEd @GeneCenter_LMU
nature.com
Nature Communications - The RNA methyltransferase activity of SPOUT1/CENP-32 is crucial for accurate mitotic spindle organization. Here, the authors describe a neurodevelopmental disorder caused by...
3
1
15
RT @Makrantoni_lab: Excited about #Fungal pathogens and the interplay with the host? Fully funded PhD in our lab @EdinUni_IRR @zje_institut….
0
10
0
RT @sweta_sikder: Exciting news! 🎉 After a long journey, my postdoctoral research is finally published! 🌟 While we often hear about telomer….
0
38
0
RT @KaustuvSanyal: In our latest #PLOSGenetics paper, @SatyaDev2064 and coauthors report that the dependence of shugoshin on Bub1-kinase ac….
journals.plos.org
Author summary Precise segregation of the genome to daughter cells is the key to cell growth, survival, and proliferation. A proper attachment of spindle microtubules to the kinetochore of each...
0
22
0
RT @FachinettiLab: Join us in Stresa, Italy for the amazing @embo Chromosome Segregation and Aneuploidy organized by @SteSantaguida @EL….
meetings.embo.org
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
0
12
0
RT @hopfnerlab: Check out our latest structural paper about human OGG1 processing DNA lesions within nucleosome core particles, in collabor….
nature.com
Nature Communications - How DNA glycosylases repair base lesions within nucleosomes remains unclear. Here, the authors determine the cryo-EM structure of 8-oxoguanine-DNA glycosylase 1 bound to an...
0
6
0
RT @dunleavy_elaine: Get in touch if you are interested in joining us in Galway!.
0
2
0
RT @KaustuvSanyal: When kids are shrunk (remember Honey I Shrunk the Kids) or cells are tiny, use the power of Expansion Microscopy. This….
0
10
0
RT @JCellBiol: #Chromosomes in early prometaphase are longer, have a more granular surface, and lack a primary constriction. From Cisneros-….
0
7
0
Also check out a parallel study with similar findings from the Musacchio lab @AndreaMusacchi1 @MusacchioLab @DuccioConti
science.org
The centromere, a chromosome locus defined by the histone H3–like protein centromeric protein A (CENP-A), promotes assembly of the kinetochore to bind microtubules during cell division. Centromere...
1
4
10
Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance @WTcell @GeneCenter_LMU @SBSatEd @LMU_Muenchen @Pragya_Sriv @bethan_medina @Alba_Edinburgh @PaulaSoteloP @ERC_Research @wellcome & MRC
science.org
Accurate chromosome segregation requires the attachment of microtubules to centromeres, epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, CENP-A nucleosomes...
11
31
106
RT @SteSantaguida: Thrilled to share our new paper in @ScienceMagazine, in which we identify p62/SQSTM1 as a critical regulator of micronuc….
science.org
Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are character...
0
55
0
RT @centromellone: An absolute honor to co-chair the Centromere Biology GRC together with @iaincheeseman! Great science, lots of first-time….
0
11
0
RT @Marston_lab: Now online. Distinct roles of spindle checkpoint proteins in meiosis - ScienceDirect With some updates from the preprint….
0
12
0
RT @AdeSaurin: Excited to reveal our new chemical-genetic system to inhibit PP2A-B56 phosphatase. We use this to characterise its substrate….
biorxiv.org
Serine-threonine phosphatases have been challenging to study because of the lack of specific inhibitors. Their catalytic domains are druggable, but these are shared or very similar between individual...
0
15
0
Great to this Mis18 story in its published form! Fantastic collaboration @UhnsooC @DinaSchneidman @jurirappsilber @OwenDaviesLab Reshma Thamkachy @bethan_medina Sang Ho Park @WTcell @GeneCenter_LMU
embopress.org
imageimageMultiple inter- and intra-molecular interfaces stabilise the overall three-dimensional architecture of the Mis18 complex and ensure centromere localisation and function of the CENP-A...
4
7
19