Interested in contributing?.Please submit an abstract here: {JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols}.

As a Guest Editor for @JoVEJournal, I am organizing a Methods Collection titled “Advanced Methods to Study Pathogenic Features of Morphological Transitions and Ploidy Changes in Fungal Pathogens.”.

RT @syncellbiolab: 📢 Get ready! The India Yeast Meeting 2025 (IYM 2025), the 13th international conference on fungal biology, is coming to….

RT @_ranabir: Happy to share our work (final aspect of my thesis). We tried to understand why neuronal and microglial cells upregulate TNTs….

RT @syncellbiolab: Excited to host the Indo-German Meeting on Cytoskeleton Biology in Health & Disease at @iiscbangalore! 🧬.🗓️ June 3–5, 20….

RT @syncellbiolab: Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian ce….

RT @biopatrika: #authorinterview @Reza_Hashim21 from @KaustuvSanyal lab talks about his work on "Moonlighting role of autophagy-related pro….

11. Huge shoutout to all the scientists Arshad Desai@oegemadesai_lab, Elmar Schiebel, @Dey_ Gautam, @SueBiggins, Guislene Pereira, @Joe_Heitman, Sunil Laxman, @syncellbiolab, and Uttam Surana for their valuable inputs and engaging discussions.

10. This work was possible with amazing colleagues & collaborators @Agg_Rashi, Jigyasa, @PodhNitesh, @mrprotein24, @GunjanM43894285, and discussions with both past and present lab members at Molecular Mycology Lab, and funding support from @DBTIndia, @serbonline, and @jncasr.

9. Together, we uncover an unusual function of an Atg11, a scaffolding protein in maintaining high-fidelity transmission of genetic material. Head to the paper ( to know more.

A big thanks to @ms_chirps for discussions related to experimentation and analyses for aMT instability.

8. We show that Atg11 facilitates dynamic instability of astral microtubules (aMTs) and prevents catastrophe frequency, which is complemented by stabilized Clb4 levels with loss of Atg11.

7. Consequently, we observed FEAR-defective phenotypes: delayed Cdc14 release, spindle buckling, and spindle positioning and alignment defects which are Kar9-dependent.

6. Increased mono-oriented kinetochores, sensed by the Aurora kinase BIpl1 activate the spindle assembly checkpoint (SAC), stabilizing securin (Pds1), and thus delaying cell cycle progression in the absence of Atg11.

To our surprise, we identified a dynamic, microtubule-dependent, pool of Atg11 at the SPBs, ‘a second home’ in addition to its cytosolic pool.

5. Are there constant pools of Atg11 at the SPBs required for MT regulation? In collaboration with @GunjanM43894285, we utilized single-molecule tracking (SMT) to answer this.

Remarkably, Atg11 in addition to its canonical localization, also localizes at the interface of vacuole-nucleus and displays a transient association with SPBs in a cell cycle-dependent manner.

4. How does a pre-autophagosome (PAS) protein Atg11 contribute to microtubule-dependent processes? The interaction network hinted towards a physical association of Atg11 with Spc72, a spindle pole body (SPB) protein.

3. We found that loss-of-function of Atg11 displays increased sensitivity to microtubule poison, thiabendazole and higher temperature (37°C), hinting towards a role of Atg11 in the microtubule-dependent process.

2. This work started as a collaborative project between @KaustuvSanyal and @RaviManjithaya labs at JNCASR. We created an interaction network of autophagy and cell cycle proteins. Intrigued by the interactions, we asked if autophagy protein(s) have any role in mitosis.