Marcus D Wilson
@mdrwilson
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Edinburgh, UK
Joined September 2012
Wonderful collaboration, really excited to see the final version out.
The paper version of our DNMT3B study is now out in @emboreports 🥳: https://t.co/mgGFHU5576 You can read more on the previous thread but here is a summary of the main updates. This is one for Southern blot fans! 🧵1/9
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The paper version of our DNMT3B study is now out in @emboreports 🥳: https://t.co/mgGFHU5576 You can read more on the previous thread but here is a summary of the main updates. This is one for Southern blot fans! 🧵1/9
embopress.org
imageimageThe DNA methyltransferase DNMT3B is recruited to gene bodies through its PWWP domain’s interaction with H3K36me3. This study shows DNMT3B PWWP mutations cause hypermethylation of H3K9me3-...
New pre-print alert 🚨 @franci_tag shows that DNMT3B PWWP mutations cause hypermethylation of H3K9me3 heterochromatin that is facilitated by its N-terminus. You can read more here: https://t.co/mQdXSUA62P But here is a quick summary 🧵 1/10
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Great talk by Hannah Wapenaar from @mdrwilson lab solving some beautiful structures and highlighting tips and tricks from data processing software packages for #cryoEM #Scottish_cryoEM23
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An amazing collaboration with @zeqiraj lab, driven by superstar postdocs Hayden Burdett and @FoglizzoMartina. Thanks to all co-authors.
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Fantastic to see the final version of this online now. Using a series of complex biochemistry we shone a light on how BRCA1-BARD1 is recruited to chromatin. https://t.co/CjBgLiuPYk
academic.oup.com
Abstract. Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in
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BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes
academic.oup.com
Abstract. Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in
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Our 10 week virtual course on the theory of cryo-EM returns again next month. Full details and registration: https://t.co/H5BxSO0Aty (NB. open to consortium member universities only)
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Join us for the first Scottish Symposium on Cryo-electron Microscopy !❄️🔬🏴 https://t.co/aKE2KFW942
@SCMICryoEM @UoDLifeSciences @UoDCeTPD @SULSAtweets co-organised with @Mark_A_Nakasone @TomOwenH @CharlCrowe
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Job Alert📢📢 We are recruiting postdocs in Protein Biochemistry https://t.co/SxA7084EHr & Cell Biology https://t.co/Gqxo79P4lj to join our lab @BiochemOxford. Join us to tackle the next big challenges in the Wnt signalling field in a fun, collaborative & supportive environment!
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We are very excited to share with you the results of great teamwork with @AmelieFT lab! In this study, two graduate students @lymphocytePC and @DessaptJcharacterized the critical role of FIRRM/C1orf112 in the disassembly of RAD51 during DNA repair.
science.org
FIRRM plays a role in the maintenance of genome stability.
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https://t.co/kmSbldd3J7 contains raw data for the "Structure of the Nucleosome Core Particle from Trypanosoma brucei", published @NAR_Open ( https://t.co/LcWO3VFIBy) by the @mdrwilson lab @EdinburghUni. #EMPIAR #cryoEM #NeglectedTropicalDiseases
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We are delighted to establish our new Discovery Research Platform for Hidden Cell Biology @EdinburghUni and grateful to @wellcometrust for support. @SBSatEd @WTcell
Discovery research has near limitless potential, but researchers can be faced with barriers too substantial to overcome alone. To address this, we are directing £73 million into eight new Discovery Research Platforms. Learn more ⤵️ https://t.co/bpf06twPqu
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Here is our latest work in which we explored the relationship between MeCP2, heterochromatin and DNA methylation using live-cell imaging. This is a collaboration with Tom Burdon @roslininstitute, Thomas Jenuwein @mpi_ie and Claude Libert @VIBLifeSciences. https://t.co/MiaLRqMMvN
biorxiv.org
Correlative evidence has suggested that DNA methylation promotes the formation of transcriptionally silent heterochromatin. Accordingly, the methyl-CpG binding domain protein MeCP2 is often portrayed...
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NucleosomeDB - a database of 3D nucleosome structures and their complexes with comparative analysis toolkit
biorxiv.org
Nucleosomes are basic building blocks of chromatin, comprising DNA wrapped around an octamer of eight histone proteins. They play key roles in DNA compaction, epigenetic mark up of the genome and...
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Brilliant 🧵 highlighting the key take home messages we learnt from our characterisation of nucleosomes from the divergent eukaryote T.brucei by @GauriDeak
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