Joseph Derosa
@JDerosaChem
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Assistant Professor @BUChemistry | Member of @derosalab | transition metal and (electro)catalysis enthusiast | NYC born and raised | (he/him)
Boston, MA
Joined August 2012
Congrats to Brett and Jillian on this incredibly powerful e-SNAr strategy! Synthetically enabling, extremely robust, and highly energy-efficient with as low as 20 mW of power at 50 mmol scale with a proposed uphill ET-promoted redox chain mechanism. Dump, stir, ⚡️ #chemtwitter
SNAr powers the engine of drug discovery and production, but electronic demands restrict access to important chemical space. We describe an e-SNAr strategy to bridge this gap that operates under air at RT with catalytic charge, simplifying scalability. https://t.co/Sk8uDTyN7x
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Metal–aryls are crucial productive intermediates in cross-coupling, though for cobalt they have rarely been observed during catalysis. Congrats to Kavita, Bhaswati on a landmark study of isolable, active cobalt–aryl catalysts for sulfone cross-coupling https://t.co/jS5uJ2gT9B
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Across two studies in @ScienceMagazine and @Nature, Phil Baran’s lab (@BaranLabReads) reveals a practical radical cross-coupling platform for constructing complex molecules using sulfonyl hydrazides—cleanly releasing nitrogen like a “rocket boost” for molecular complexity. With
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Fantastic visit at @UniofNottingham School of Chemistry today sharing some of our recent work in @derosalab using voltage control to enable selective electrosynthesis and catalysis. Thanks to @miriamoduill for the gracious hosting and organizing great discussions with faculty!
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Great work from @ChirikGroup’s Adam and POP as well as our collaborators @bmsnews @ChicagOChemO @stevewiz06, Heejun Lee and Eric Simmons.
Phenoxyimine Iron Aryl and Alkoxide Complexes as Reactive Intermediates in Iron-Catalyzed C(sp2)–C(sp3) Suzuki-Miyaura Cross-Coupling | Journal of the American Chemical Society @PrincetonChem @Princeton @pchirik
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Bit late, but congrats to Zi, Ethan, and Bryan on an insightful study highlighting the impact of redox mediators on electroreductive Fe catalysis! We anticipate that this approach to access low-valent Fe will expand the electrocatalytic toolkit for organic synthesis. Stay tuned!
Congrats to Zi and team on the publication of our study on a redox mediator strategy to electroreductively harness Fe(I) in alkyne semi-hydrogenation! This work is now published in @ACSCatalysis - stay tuned for more from #TeamFe. #chemtwitter #newPI
https://t.co/ovKaz3k28s
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Congrats to Zi and team on the publication of our study on a redox mediator strategy to electroreductively harness Fe(I) in alkyne semi-hydrogenation! This work is now published in @ACSCatalysis - stay tuned for more from #TeamFe. #chemtwitter #newPI
https://t.co/ovKaz3k28s
pubs.acs.org
The development of electroreductive Fe-catalyzed processes for organic synthesis has remained scarce compared to other earth-abundant metals despite inherent advantages such as cost, low-toxicity,...
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One week to go! 2025 OM Bootcamp @scrippsresearch kicks off on Aug 4th, 8 am PT. Welcoming participants in-person or over zoom, synchronous or asynchronous, low-spin or high-spin. Register👇 https://t.co/wXAQxOsan2
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This is how you enable uptake of a new method! Hats off to the Knight Chemicals team for making a hydrazides coupling starter kit tailor made for medicinal chemists! Obviously I’m biased since I adore @BaranLabReads chemistry and the folks that develop it but dang what a product.
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Calling all organic chemists! Come present in Worcester, MA! https://t.co/qiqOGONWAb
acs.org
Call for Abstracts: Northeast Regional Meeting (NERM) 2025
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**US-CAN Doctoral Excellence Award @WesternU -$160,000 to 25 PhD students for up to 4 years. - Must've had offer rescinded/cancelled from US school. -Expedited admission process. -Feel free to reach out, if interested in a PhD in inorganic chem! https://t.co/OejGUFExKE
forbes.com
Western University, one of Canada’s leading public research universities, is launching an initiative aimed at luring away PhD students from premier U.S. institutions.
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Simplifying Synthesis with Radical Cross-Coupling | https://t.co/gX8xFaWYZj The recording of Phil Baran's (@BaranLabReads) Flash Talk, "Simplifying Synthesis with Radical Cross-Coupling" is now available on our YouTube Channel. Phil highlights how his group combines
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We are grateful to the @acsprf for funding our proposal on arene functionalization strategies for upconversion of aromatic feedstocks! Congrats to all the awardees this cycle:
cen.acs.org
The spring 2025 grants total $8,630,000 in researcher investments
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We say: time to spiro! A fantastic work from Marylise Triacca in collaboration with @AstraZeneca: Out in Green Chem: #eSpiro – a metal-free, scalable electrosynthetic route to spiroketals via anodic oxidation. https://t.co/K1fk10AUeG
#OrganoEchem #GreenChem #RealTimeChem
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atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in @ChemRxiv. 🧐🪞 https://t.co/76QEU36cr3
@ASimlandy @0iTurki @pengliu_group
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Another @Orgmet_ACS Flash Communication! From @ChirikGroup's Cherish Nie on Ni-promoted ring opening of vinylcyclobutanes.
pubs.acs.org
The C–C activation of three substituted vinylcyclobutanes by [(IPr)Ni(0)] (IPr = ((1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) complexes was evaluated. Both 1,2-dicyclobutylethylene and...
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SNAr powers the engine of drug discovery and production, but electronic demands restrict access to important chemical space. We describe an e-SNAr strategy to bridge this gap that operates under air at RT with catalytic charge, simplifying scalability. https://t.co/Sk8uDTyN7x
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Harnessing reduced Fe in electrocatalysis faces many challenges with respect over-reduction and catalyst instability. In this preprint, we describe a redox mediator strategy to tame a (P3P)Fe(I) species for semi-hydrogenation of alkynes as a model study: https://t.co/DPw0qpcxr2
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Standing on the shoulders of giants, we venture into reduced Fe electrocatalysis enabled by a redox mediator strategy. We are excited to use the lessons learned from this study to develop new forms of reductive Fe electrocatalysis! #chemtwitter #teamFe
Harnessing reduced Fe in electrocatalysis faces many challenges with respect over-reduction and catalyst instability. In this preprint, we describe a redox mediator strategy to tame a (P3P)Fe(I) species for semi-hydrogenation of alkynes as a model study: https://t.co/DPw0qpcxr2
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Just out on ChemRxiv! We report a carbonylative ring expansion of cyclic carboxylic acids via a spin-center shift mechanism. This strategy provides modular access to valuable sp³-rich cyclic scaffolds from readily available carboxylic acids. https://t.co/OG4DtJPDJw
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