Engle Lab
@EngleLab
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catalysis, reaction discovery, and samoyed sled racing @scrippsresearch. views our own.
La Jolla, San Diego
Joined September 2015
🎥 My graduate-level #Organometallics course is now live on @YouTube! #chemtwitter Designed for PhD chemists, this series covers history, mechanisms, catalysis, ligand design & more. Offered once every 2 years—check it out anytime! 📺
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We’ve loved promoting @fleetscience Discovery Day all week, and it starts TODAY at 10 AM! Stop by to meet @scrippsresearch students & postdocs and explore hands-on science fun. 🔬🌟 #CommunityScience #STEMEducation
Lights, camera, science! 🎬🔬🌟 Scripps Research Dean of Graduate and Postdoctoral Studies Keary Engle, PhD (@EngleLab), and postgraduate students Jia Meng Pang (@JiaMeng_Pang) and Paige Bensing joined @KUSINews to share a sneak peek of Discovery Day at @fleetscience!
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Equivalent Atrop- and Positional Isomerism in Styrene Derivatives Prepared by Enantioselective 1,3-Diarylation | Journal of the American Chemical Society @EngleLab @scrippsresearch
pubs.acs.org
Isomerism, the ability of a single set of atoms within a molecule to exist in different three-dimensional spatial arrangements connecting through distinct bonding networks, gives rise to distinct...
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The peer-reviewed version of this paper is online this week in @J_A_C_S. We discovered a Pd/amino acid cocatalytic route to styrenes with coexisting atrop- and positional isomerism—a rare dual isomeric phenomenon. https://t.co/xKyeuCCphP
pubs.acs.org
Isomerism, the ability of a single set of atoms within a molecule to exist in different three-dimensional spatial arrangements connecting through distinct bonding networks, gives rise to distinct...
atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in @ChemRxiv. 🧐🪞 https://t.co/76QEU36cr3
@ASimlandy @0iTurki @pengliu_group
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C(sp3)-C(sp3) couplings w/o radicals? 🧐 We introduce alkyl-9-BBN reagents to the 3-component coupling party 🎉, enabling access to new encoded cyclooctene monomers for ROMP 🧵 w/ @pengliu_group @GuteGroup
@ChemRxiv: https://t.co/kXrINZmAcS 🧪 #TeamNickel #PolymerChem
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The final peer-reviewed version of our study on Cu(II) as a π-Lewis acid is online this week in @J_A_C_S. Hats off to @sunjuntao1 and our collaborators in the @pengliu_group! Already this has opened up many new rxns we are eager to share soon! 🧐 https://t.co/cG1SLV47kR
pubs.acs.org
A copper(II)-catalyzed stereodivergent hydrooxygenation of electronically unactivated alkynes with carboxylic acids is reported. Regioselectivity and kinetic reactivity are facilitated by a bidentate...
>3 years in the making, we are excited to debut @sunjuntao1's discovery of copper(II) as a potent π-Lewis acid catalyst for redox-neutral, regiodivergent OH and NH additions to unactivated alkynes. Great teaming up w/ @pengliu_group. @ChemRxiv
https://t.co/RGdrzpyqhK
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Cu(II)-Catalyzed Hydrofunctionalization of Unactivated Alkynes via π-Lewis Acid Activation | Journal of the American Chemical Society @scrippsresearch @EngleLab
pubs.acs.org
A copper(II)-catalyzed stereodivergent hydrooxygenation of electronically unactivated alkynes with carboxylic acids is reported. Regioselectivity and kinetic reactivity are facilitated by a bidentate...
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What a great thrill and honor to be recognized by the @ACSGCI Green Chemistry Challenge Award this year. Member of the lab past and present, together with collaborators from #BMSChemistry and @UCSDChemBiochem, traveled to @theNASciences in DC this week for occasion. #teamnickel
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Fantastic visit at @UniofNottingham School of Chemistry today sharing some of our recent work in @derosalab using voltage control to enable selective electrosynthesis and catalysis. Thanks to @miriamoduill for the gracious hosting and organizing great discussions with faculty!
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One week to go! 2025 OM Bootcamp @scrippsresearch kicks off on Aug 4th, 8 am PT. Welcoming participants in-person or over zoom, synchronous or asynchronous, low-spin or high-spin. Register👇 https://t.co/wXAQxOsan2
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This is how you enable uptake of a new method! Hats off to the Knight Chemicals team for making a hydrazides coupling starter kit tailor made for medicinal chemists! Obviously I’m biased since I adore @BaranLabReads chemistry and the folks that develop it but dang what a product.
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Autograph signings @ACSorganic 2025 National Organic Chemistry Symposium! Future scientists with some of our plenary speakers: Keary Engle (@EngleLab), Jenn Allen (@Amgen), Morten Meldal and Melanie Sanford (@MichiganChem) #NOS2025
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Prof. Jin-Quan Yu (@YulabJin) will receive the 5th Akira Suzuki Award for his research on C–H bond activation, which makes it easier to build complex molecules. His work accelerates advances in pharmaceuticals, molecular tools and materials science. More:
magazine.scripps.edu
Jin-Quan Yu, the Bristol Myers Squibb Endowed Chair in Chemistry and the Frank and Bertha Hupp Professor in Chemistry at Scripps Research, has been selected as the recipient of the 5th Akira Suzuki...
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The age old question: what's happening in the flask? 🧪🤔 Join G2 student @avrlisboa for a ⏲️ brief video primer on ReactIR as a tool to answer this question and free up your time! https://t.co/T06nnhn7Yl
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atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in @ChemRxiv. 🧐🪞 https://t.co/76QEU36cr3
@ASimlandy @0iTurki @pengliu_group
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Unexpected reactivity → simple access to dihydro-1-benzazepines! Now out in TL 🎉 Part of a special issue celebrating @SongLinLab's Tetrahedron Young Investigator Award 🏅 Big thanks to undergrad Letian + the whole team 🙌 https://t.co/8pb7ptz4k1
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Great to see @derosalab out in full force! This team is crushing it!
Best way to cap off an amazing #ACSSpring2025 meeting. Always feels like home @scrippsresearch - now with an extended academic family tree!
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Enormous congratulations to the entire team!
🧪A team from @GouverneurGroup @OxfordChemistry have developed a method to destroy fluorine-containing PFAS (sometimes labelled “forever chemicals”) while recovering their fluorine content for future use. 🔎Find out more:
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