Alf Honigmann
@Honigmann_Lab
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Membrane Organization in Cells and Tissue, STED-Microscopy, Biophysics, Reconstitution, 3D Tissue Culture. TU-Dresden and MPI-CBG
Dresden, Sachsen
Joined March 2018
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet (@jvveenvliet) @mpicbg @PoLDresden 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ https://t.co/slJgS87a1k
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The Lipid Brain Atlas is out now! If you think lipids are boring and membranes are all the same, prepare to be surprised. Led by Luca Fusar Bassini with Gioele La Manno's lab, we mapped membrane lipids in the mouse brain at high resolution. https://t.co/q3AeqGsIS1
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🎉Finally: tomorrow Sept 29 we open BIOMEMBRANE DAYS 2025 in Berlin: 3 days packed with exciting science on membranes! Looking forward to an amazing program of invited & contributed talks, posters & lively discussions. 🔗 https://t.co/hfuRVamPCc
@EwersLab T.Weikl @MpiciPotsdam
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New graduate school focusing on biomolecular condensates. Apply now and do your PhD to beautiful Dresden.
Accepting applications from highly motivated Masters degree holders with prior research experience to take on interdisciplinary thesis projects in Dresden on the physical properties & biological functions of Biomolecular Condensates. Apply before 24.10.: https://t.co/8pWxOebO16
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Exciting application of our programmable #CellCulture matrix #DyNAtrix. By creating a dynamically reconfigurable microenvironment, we can now invert & guide epithelial cell polarity in real time. https://t.co/gQTZTS6Hyw
#Biophysics #DNAnanotech #TissueEngineering #Biomaterials
advanced.onlinelibrary.wiley.com
A synthetic DNA-crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct...
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🗺️🔬 A first-of-its-kind map of lipid traffic is demystifying an important yet elusive aspect of how cells work. Read the study, out now in @Nature, by ADIs @honigmann_lab, @nadlerlab, and collaborators: https://t.co/tQfPMDEd1A
#FrontierScience
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Collaboration work on the computer modeling and simulations for growing cell/lumen assembly, led by Dr Tanida (UTokyo) @c100percent , with Prof Sano, Prof Nonomura, Dr Fuji and their HFSP teams, @RivelineLab @Honigmann_Lab Prof Grapin-Botton’s lab.
Our new paper is out!🥳 🧫 Mini-organs grown from cells in 3D culture = organoids. In our study, we built a phase-field model that includes ⌚ the cell division cycle and 💧 lumen pressure to explore how organoid shapes are determined. https://t.co/tjzAQ6TjAa
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It is out now with some interesting revision results:
nature.com
Nature - Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
Here’s the big one: In collaboration with @Honigmann_Lab, @LabShevchenko, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. https://t.co/uotVrHnbsK
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🚨 New paper alert! 🚨 Can we simultaneously achieve deep, high-res, large field-of-view imaging without the usual trade-offs? 🤔 🧬🔬 YES: #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC_OPR)! #SuperResolution 📄 https://t.co/YKYgcDyMLG
@NatureComms 🧵👇
nature.com
Nature Communications - Zaza and colleagues demonstrate that DNA-PAINT on a spinning disk confocal microscope with optical photon reassignment enables high-resolution imaging across large fields...
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We did it! 😀🎉 🍾🥂 Our Excellence Cluster Physics of Life (@PoLDresden) got renewed until 2032! I am so proud of our team and all the great work we did to achieve this. At a personal level, I am really happy that the enormous effort that went into this process was successful,
Great news! 🎉 Our Cluster of Excellence Physics of Life has been renewed for a second funding phase (2026-2032) by @dfg_public! Thanks to everyone who made this possible! 👏 We're thrilled to continue our cutting-edge #research towards understanding what brings matter to life!
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📢Registration is open for the Biomembrane Days 2025! 🔗 https://t.co/hfuRVamhME A top-notch lineup of speakers, 120 posters, 200 scientists 📜Submit an abstract by July 14 🏆3 Poster prizes ⚠️Limited spots - previous events were fully booked! #BiomembraneDays2025 #CellMembranes
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Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution We are excited to present our latest work published in @NatureComms
https://t.co/zVelVqqrKl
nature.com
Nature Communications - Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that...
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In @ScienceAdvances, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains https://t.co/sWDbLiPOFJ (1/n)
science.org
The metabolism of ergosterol shapes this lipid to allow the formation of fluid membrane domains in yeast cells.
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#PacManoid was so hungry that it ate the original post 🍬🍬🍬🍬🍬. Here’s the thread on our latest in @CellStemCell again! @mpicbg @PoLDresden (Imaging: @VillarongaAlba; Animation: Michael Weber)
📢 Now in @CellStemCell! Our @teamstembryo tour de force led by @RyanSavill4 & @VillarongaAlba @mpicbg
#gastruloids with a sweet tooth become more embryo-like: https://t.co/3IY3qFKR2t [reposting 🧵 since we were informed about copyright concerns regarding "Pacmanoid" in OP]
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Many thanks to the IPF and Friends of IPF for the Innovation Award 2024 and big congrats to the whole team! https://t.co/0r7S0N7hIh
nachrichten.idw-online.de
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Come to #Prague for #Woodstock2025. What is it? A scientific conference unlike any other. Think #BurningMan or #MusicFestival but #science themed. It'll have two parts - decentralised sessions spread in #Prague (sightsee as you move around) & #campsite event to wrap it up (1/7)
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Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells https://t.co/kQBuhAHYRG
biorxiv.org
All cells are subject to geometric constraints, including the surface area-to-volume (SA/V) ratio, which can limit nutrient uptake, maximum cell size, and cell shape changes. Like the SA/V ratio of a...
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ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
https://t.co/ukJcD7aZsE
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