Collective dynamics of focal adhesions regulate direction of cell motion. Our ratchetaxis article just appeared in Cell Systems. https://t.co/DicLPhFzTI #CellMotility #Ratchetaxis #Directionality #FocalAdhesions @unistra @cnrs @igbmc @CellPressNews

https://t.co/uv4ZPLWqcq

A fruitful interaction with @Honigmann_Lab in our @HFSP network with Masaki Sano and @anne_grapin Labs. https://t.co/ynTSuzZkO3

Jan. 2023 Call : The Cell Physics Master recruits now for September 2023 with international lecturers and practicals in Strasbourg (France) : https://t.co/uj3biedH6F Applications https://t.co/k1Cj4VSyKi 3D imaging of an eye of a live zebrafish N. Peyriéras and A. Klymchenko

In a separate study using experiments & continuum model, we show that cell stiffness dependent height variations are important for generating the pulsations in monolayers & in setting their lengthscales ( https://t.co/UuBGIalCdd). 7/7

We used a vertex model to understand the transition to pulsations & flows. We found that a dominating velocity-polarity alignment led to flows but when the velocity-polarity alignment matched the rotational diffusion, pulsations emerged. 6/7

Thus by tuning external substrate friction & the internal cytoskeletal organization we can force the monolayers to behave in a unique way - pulsate/flow. We also found correlated myosin accumulation & lamellipodial alignment during pulsations & flows, respectively. 5/7

As a standard, we then checked the role of cytoskeleton using inhibitors. The inhibitors suppressed the pulsations, but when we tried to get back the pulsations by washing out & restoring cytoskeletal activity, there were no pulsations – but long range flows. 4/7

Using spatially periodic micropatterns of various sizes, we trap the pulsations & demonstrate that substrate friction regulates pulsation sizes. By increasing the relative friction between adhesive patterns & PEG regions, we further substantiate the role of friction. 3/7

We observed the dynamics of large confluent MDCK monolayers & found spontaneously emerging, locally oscillating & flowing domains (10-15 cells ~ 200 µm). Characterizing them using divergence & velocity magnitude, we asked what determines their lengthscales. 2/7

Our study from @Raghavan_Thiaga came out recently in @iScience_CP ( https://t.co/RTbNWs7K6b…). We show how two coexisting collective epithelial dynamics - pulsations & flows - are regulated. 1/7

Another Movie showing Cell motility in 3D Matrix. Our article with @PierreSens and collaborators appeared in @eLife. #CellMotility #CellMigration @unistra @INSB_CNRS @INP_CNRS @IGBMC https://t.co/eyLtXQLqjF… @eLife

3D single cell migration driven by temporal correlation between oscillating force dipoles. Our article with @PierreSens and collaborators appeared in @eLife. #CellMotility #CellMigration @unistra @INSB_CNRS @INP_CNRS @IGBMC https://t.co/eyLtXQLqjF @eLife

Our review on computational approaches to study luminogenesis with @HiraiwaTetsuya and co-authors just appeared : https://t.co/Q2GWi9zeHR

#FRANCE: The Cell Physics Lab. @unistra offers support for a scientist at any stage through a Human Frontier Science Program special call. The research involves cell biology, microscopy, micro-fabrication, theory. https://t.co/9s2ILkkk8M #ScienceForUkraine

The Cell Physics Master II @unistra https://t.co/uj3biedH6F has started Sept. 1. #Biology #Physics #internships If you can host a student for a 4-months stay (March-June 2022), please send to rotation@cellphysics-master.com a one-page-pdf with topic/project and lab./contact.

We celebrated today 4 recent PhDs at @DevStem_Igbmc who graduated from the first years of the new @Cellphysics Master @unistra : Basile from @CharvinLab, Simon from @RivelineLab, Gui from @molina_lab, Hélène from @julien_vermot Congratulations to each of them.

New call for short stays from students and researchers @unistra in Dresden, sponsored by the city hall of Strasbourg @strasbourg in the twin city program Strasbourg-Dresden @stadt_dresden https://t.co/gmrpcJ47H3

Another perspective : The side view of a migrating cell - live. For more details, see our article #Comelles et al. Biophys J. 107:1513–1522 (2014). https://t.co/iTsFJMr41a

Epithelial colonies in vitro elongate through collective effects. Nematic field alignment precedes colony elongation. The full version now available in @eLife : https://t.co/B07q2WWgoV @JordiComelles @unistra @INSB_CNRS @INP_CNRS @IGBMC

Epithelial colonies in vitro elongate through collective effects. Our article with @JordiComelles and Mandar Inamdar just appeared in @eLife https://t.co/B07q2WWgoV @unistra @INSB_CNRS @INP_CNRS @IGBMC in collaboration with #mpipks @iitbombay @TheCrick