Now online: October 2025 Issue. - Focus Issue on #biosensing - DNA moiré superlattices - Sugars at Ångström-resolution - Solid-state #nanopores - Non-aqueous Li #batteries - Neuromorphic vision - Peptide #hydrogels - Deep learning for #LNPs & more. https://t.co/3npwoNaUfu

Our article "Ångström-resolution imaging of cell-surface glycans" on the cover of Nature Nanotechnology! 🤩 @NatureNano https://t.co/DHWKUV2Bmt

Thrilled to announce some big news! I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, starting early 2026.

Huge thanks to all authors and collaborators whose effort made this possible. @EduardUnterauer @EvaSchentarra @IBaudrexel @taisha_tashrin Jisoo Kwon Sebastian Strauss @jekriste @rafalkowalew @FelipeOpaz_o @euforna @l_masu (6/6)

Within this neuronal atlas we can reveal the three synapse classes, excitatory, inhibitory and the recently discovered mixed synapse. Organelle imaging of Peroxisomes (Pmp70) and the Golgi Apparatus (Golga5) reveals rare contact sides and even fused particles. (5/6)

To show the power of the technique, we acquired a 13-plex 200 x 200 µm2 neuronal atlas in 3D. With this atlas, we map the interaction architecture of three neurons, resolving organelles, cytoskeleton, vesicles and synapses at single-protein resolution. (4/6)

We demonstrate speed-optimized left-handed DNA-PAINT by characterizing the sequence binding kinetics and resolving three main microscopy benchmarking targets, mitochondria, microtubules and nuclear pore complexes with < 5 nm localization precision. (3/6)

The mirrored design of left-handed oligonucleotides allows the extension of the common 6 speed-sequences R1-R6 with their analogs L1-L6, enabling 12 target multiplexing with a standard secondary label-free DNA-PAINT workflow. (2/6)

Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest publication in @NatureComms, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀 https://t.co/dIUn2CbxmI

Congratulations to everyone involved: @IBaudrexel, @l_masu, @SusanneReinhar3, Jisoo Kwon, Ondřej Skořepa, Maite Llop, Sylvia Herter, Marina Bacac and Christian Klein. (6/6) Read the full story here:

The shift from Type II to Type I function reveals a structure–function continuum for anti-CD20 antibodies, showing that receptor arrangements dictate mechanism of action. RESI provides a platform for structure-guided antibody development, applicable far beyond CD20. (5/6)

We showed a direct link between CD20 oligomerization and function by investigating OBZ-based T-cell engagers (TCEs). An increased IgG flexibility in the 2+1 TCE format lead to increased CD20 tetramerization, without higher-order clustering, reducing direct cytotoxicity. (4/6)

In contrast, Type II antibodies like Obinutuzumab and H299 induced limited oligomerization to dimers, trimers and tetramers, consistent with their role in promoting direct tumor cell death rather than complement activation. (3/6)

By imaging intact cells, we could see these therapeutic antibodies in action: Type I antibodies like Rituximab and Ofatumumab formed extended chains of CD20 hexamers or larger, creating platforms compatible with complement protein binding, mediating cancer cell killing. (2/6)

Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)

We're excited that the study is now out in Nature Nanotechnology @NatureNano

Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab - congrats to first authors @KarimAlmahayni and @l_masu and to the whole team!

Congratulations to Ralf on your election as a new EMBO member: ❕Original press release from @EMBO: https://t.co/IBS7qKyJXl

@MoniqueHonsa, @PhilippSteen, Larissa Heinze, Shuhan Xu, @heerpa, @IBaudrexel, @SusanneReinhar3, Ana Perovic, Jisoo Kwon, Ethan Oxley, Ross Dickins, @IkbenMaartje, @IanParish_AU

Big congrats to @l_masu and @rafalkowalew who led the project as well as other co-authors that contributed to this work!!