Han Yang
@HanYang_Henry
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Postdoc at @UCSF with @YinShenlab. Passionate about developing innovative tools to address genetic questions related to diseases. Larry L. Hillblom Fellow.
Joined June 2022
RT @NatureRevGenet: Evolution of splicing model architectures Figure from our recent Review: From computational mod….
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RT @s6juncheng: Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matche….
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RT @LomvardasLab: Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical….
cell.com
In lieu of traditional genetic variant testing approaches, an approach using scalable variant classification in primary human T cells with a clinically relevant readout can inform rapid diagnosis and...
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RT @NatureBiotech: A machine learning model for prime editing efficiency prediction takes into account chromatin context .
nature.com
Nature Biotechnology - A machine learning model for prime editing efficiency prediction takes into account chromatin context.
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Excited to be part of this amazing HAR project! 🎉 Congrats to the whole team! 🚀.
How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ 1/12.
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RT @MarkTransposon: How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Tog….
nature.com
Nature - The cis-regulatory functions of human accelerated regions of genomic loci and their potential contribution to human brain evolution are revealed.
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RT @NatRevNeurosci: Understanding the molecular diversity of synapses — a Review by Marc van Oostrum & Erin M. Schuman..
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RT @cedricboeckx: Several excellent Human Cell Atlas papers in @nature this week. Highlights for me:.1. The integrated transcriptomic cell….
nature.com
Nature - A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid...
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RT @JCoolScience: Flexible differential expression analyses have always been neat in CZ #CellxGene. Now they’re next level! Quickly perform….
cellxgene.cziscience.com
Find, download, and visually explore curated and standardized single cell datasets.
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RT @emauryg: Excited to share my lastPhD publication! We discovered non-inherited mutational patterns in schizophrenia occurring before bir….
science.org
Germline mutations modulate the risk of developing schizophrenia (SCZ). Much less is known about the role of mosaic somatic mutations in the context of SCZ. Deep (239×) whole-genome sequencing (WGS)...
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RT @JingyiRen: Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to pu….
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RT @LabWaggoner: Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rathe….
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RT @MathiasEder91: Have you ever wondered about how the genomic position of regulatory elements impact their functional output? Check out o….
biorxiv.org
Genes are often activated by enhancers located at large genomic distances. The importance of this positioning is poorly understood. By relocating promoter-reporter constructs into >1,000 alternative...
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RT @robert_froemel: Excited to share my PhD work in the lab of @larsplus @CRGenomica. We screened the activity of synthetic enhancers throu….
biorxiv.org
During cellular differentiation, enhancers transform overlapping gradients of transcription factors (TFs) to highly specific gene expression patterns. However, the vast complexity of regulatory DNA...
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RT @sara_mostafavi: Our commentary (with Alex Sasse @LXandR_ and Maria Chikina @ChikinaLab ) on past and future of sequence-to-function de….
nature.com
Nature Methods - By exploiting recent advances in modern artificial intelligence and large-scale functional genomic datasets, sequence-to-function models learn the relationship between genomic DNA...
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RT @leyla_aakay: I'm excited to share our latest work, out today in @Nature. Grateful to work with amazing co-leads @MathysHansruedi @carl….
nature.com
Nature - A regional atlas of the ageing human brain—spanning six distinct anatomical regions from individuals with and without Alzheimer’s dementia—provides insights into cellular...
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RT @nicopmat: Our paper exploring the effect of chromatin on prime editing and diverse pegRNA designs was published today! 👨💻🧬🎉. https://t.….
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RT @oncodaily: We developed (scG2P) for targeted co-capture of DNA and mRNA with Mission Bio! - @landau_lab.@nygenome @biorxivpreprint @den….
oncodaily.com
Dan Landau: We developed (scG2P) for targeted co-capture of DNA and mRNA with Mission Bio! / Associate Professor, cancer, clonal outgrowth, Dan Landau,
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RT @LarsMSteinmetz: We are very happy to share our preprint (D. Lindenhofer et al.) of a high-throughput targeted scDNA-scRNA-seq (SDR-seq)….
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