In a step toward a #liquidbiopsy for small cell #lungcancer, a Fred Hutch team led @DMacPhersonLab and @GavinHa have developed an approach that can distinguish several #SCLC subtypes from blood samples.

So excited to share our work on tumor genomes of African ancestry in common cancers. We report several actionable associations, including a novel ancestry-smoking interaction impacts TP53 rate. More discoveries to come if we improve diversity in genomics!

Congrats to Robert Patton for being awarded the @PCF_Science 2023 Young Investigator Award & achieving the top scoring application! Honored to be his co-mentor with PeteNelson. #PCFRetreat23

The #MahanFellowship supports young scientists in the early stages of their careers. We offer fellows a 21-month stipend as they pursue their proposed research project, alongside a mentor in one of our Herbold Computational Biologist labs. Apply today:

Have you ever wondered if 3’UTR point mutations found in cancer patients matter? We’re excited to share our new publication out today @CellReports, where we’ve defined how prostate tumor 3’UTR mutations affect molecular & cellular oncogenicity. https://t.co/MhKM0S2uZW 1/n

Check out the Cancer Discovery papers highlighted in the new @AACR Journals collection, Liquid Biopsies. https://t.co/SXXVYrC1LR @GavinHa

Excited to share our recent work on KaryoCreate, a new method to engineer chromosome-specific gains and losses in human cells with @SteSantaguida and @GiuntaLab https://t.co/Eg7aEDAB7u Check out also recent similar and complementary work by @LensSusanne and @McClellandLab!

Attending the Major Symposium at #AACR23 about Liquid Biopsy? See the related paper published in @CD_AACR: Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced #ProstateCancer Phenotypes by @GavinHa and @Navonilde https://t.co/rLrNZ00kcr

Excited to share our paper @NatureComms on STEAP1 CAR T cell and tumor-localized IL-12 for prostate cancer: https://t.co/O0J01xadnV Congrats to lead author @vipulbhatia24! Thanks to our collaborators @BioengIshihara @SaulPriceman @sriv4000 @fredhutch @Prostate_IPCR @PCF_Science.

Fred Hutch is recruiting a faculty member for our #prostatecancer research program. Focus areas include primary prevention, etiology, genetics/genomics, epigenetics, tumor microenvironment, metastasis, development of novel therapeutics and more. Apply: https://t.co/shBLW17Ji6

Recently published: @gavinha et al. develop Griffin, a #computational framework for #tumor subtype classification based on #cfDNA #nucleosome profiling that can work with ultra-low pass #sequencing data #CancerResearch @natrescancer https://t.co/i8774BLCnQ

In the March issue of Cancer Discovery— Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced #ProstateCancer Phenotypes, by @Navonilde, Robert Patton, Peter Nelson, @GavinHa et al https://t.co/8NvLtDOYlI @fredhutch #LiquidBiopsy #cfDNA #ctDNA

📢Prostate Cancer Scientists (PhDs, MD/PhDs, or MD scientists) - join us at Fred Hutch! New lab-based PC position (wet or dry) posted! https://t.co/bRxW1bOB2l Email Pete! (pnelson@fredhutch.org) @PCF_Science @HsiehLab @jklee_lab @BurcuDarst @DanLinMD @fredhutch @PGrivasMDPhD

Faculty position opening! Assistant or associate faculty professor in the @fredhutch Prostate Cancer Research Program! Broad research expertise considered (e.g., prevention, genetics/genomics, therapeutics): https://t.co/L4lAWPjz9X @NewPI_Slack @FuturePI_Slack #prostatecancer

We have an open joint-postdoc position with @DMacPhersonLab to work on new computational approaches for studying #lungcancer using #liquidbiopsy. If you're interested in cancer genomics, LBx, AI or #PrecisionOncology, pls apply! https://t.co/IN4uOWTRy0

Can an integrative approach reliably detect urine tumor DNA in localized #bladdercancer patients? We addressed this in our latest paper, out now in @Nature_npj Precision Oncology. https://t.co/ZujsTamd4H @ZacharySmithMD @WashU_Uro @WashURadOnc @WashU_ctDNA @WashUDPS 1/15

Thanks for highlighting this work on tumor subtyping from ctDNA. Congrats also to @Navonilde RobertPatton AnnaLisaDoebley and many collaborators @fredhutch @DanaFarber @StoverLab

Thrilled to share my views as a new PI!

Ever wonder wonder why prostate cancer cells become heterogeneous with treatment? @Alexrnagerm from @HsiehLab did for his @MCBSeattle PhD work and it is so great to see his paper accepted and out today in @eLIFE ( https://t.co/iELUHi4crs). Check out his tweetorial too!

The #MahanFellowship supports young scientists in the early stages of their careers. We offer fellows a 21-month stipend to pursue proposed research w/ a mentor in our Herbold Computational Biology labs @fredhutch. Apply today: