Eva Grönroos
@EvaGronroos
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Scientist @TheCrick cancer biology EU member
Joined June 2020
A huge thank you to everyone who has supported and contributed to this work!
Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling” out in @NatureComms. https://t.co/e5AYdyrnbx 🧵
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Comment: Capturing heterogeneity in PDX models: representation matters https://t.co/8i28bo1Myq
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My @SwantonLab postdoc paper is now out @NatureComms. It was a huge privilege to work with the TRACERx team. Thanks to @AMIHuebner and Dave Pearce, as well as everyone else @uclcancer, @TheCrick and @CRUK_MI who made this happen.
Patient-derived xenograft (PDX) models allow cancer researchers to study tumour tissue from patients in mice. Our @CRUKLungCentre paper @NatureComms describes 48 new PDX models and highlights the importance of intratumor heterogeneity in the development of cancer models (1/9)
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I am excited to announce the publication of our manuscript out today, with @DrPhilippeGui, @CharlesSwanton, @SwantonLab, @BivonaLabUCSF, @Downwardlab, and @HarrisLabUTHSA! 🧵 1/15 https://t.co/RfwSDgmXpc
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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Very excited that our paper on B cells and immunotherapy in lung cancer is out today @Nature . A privilege to work alongside @KevinWNg @EnfieldKatey on this. Give it a read ✨✨ https://t.co/H3vuFM667W
nature.com
Nature - In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.
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All of the congratulations in the world to amazing PhD student @C_M_Heffner, co-supervised with @isaacs_adrian and examined today by @ReidLab_HSP and @SchiavoMNPlab! What a privilege it was to have you do your PhD in our labs, thank you so much for your fantastic work!!!
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In conclusion, to understand a cancer’s evolution and trajectory we need to consider both genetic and non-genetic diversity. Lots more to enjoy in the paper so please read! Code is available here https://t.co/rTvHnm6mNq and the data is on EGA https://t.co/xFfiYXjUKY 8/9
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Finally, we used genomic and transcriptomic features to predict which region of the primary would go on to seed metastasis. Both genomic (especially relating to recent subclonal expansions) and transcriptional features were predictive. 7/9
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Our paper together with @SwantonLab @CharlesSwanton ‘Genomic-transcriptomic evolution in lung cancer and metastasis’ comes out today @Nature. https://t.co/VIODHRQqu7 Read all about it 🚨👇 1/9
nature.com
Nature - Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx...
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Congratulations @KevinWNg @jboumelha @EnfieldKatey @JulianDownward George Kassiotis @CharlesSwanton and #TRACERx team for your @Nature paper. Read below to find more about the study on retroviruses and #LungCancer⬇️
Excited to share our work finding an unexpected role for tumour-reactive B cells in immunotherapy response in lung cancer, led by @KevinWNg @jboumelha @EnfieldKatey, now published in @nature with @CharlesSwanton and George Kassiotis labs @TheCrick
https://t.co/zUJZdekNLI
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Retweeting a little late but such an important study! It is estimated that vaccinations have prevented around 50 million deaths in the last 20 years.
#OnThisDay in 1955, American virologist Thomas Francis announced that the polio #vaccine developed by Jonas Salk was "safe, effective, and potent", following the largest medical experiment in history at the time involving 1.8 million children across the USA.
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We're thrilled to share work on tumour evolution in 421 TRACERx lung cancer patients by @AFrankell @Michi_Dii @drmaiseb @LimEmilia @TakKarasaki @Ward__Sophie RajuVeeriah @ColliverEmma @AMIHuebner @abi_bunkum @ZaccaSimo @MariamJHanjani @NickyMcGranahan🧵⬇️ https://t.co/x6fntrEkym
nature.com
Nature - Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and...
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Our director Paul Nurse, @royalsociety, and @physicsnews have called on negotiators to agree a deal on #HorizonEurope for the sake of scientists in the UK and the EU 🇬🇧🇪🇺 🔗 https://t.co/sBlkIHuXcE
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Thoughtful @nature news and views by Allan Balmain @UCSFCancer @UCSF on how air pollution promotes lung cancer through inflammation, summarizing an elegant study by @CharlesSwanton.
nature.com
Nature - Cellular insights into mechanisms underlying pollution-associated cancer.
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A study in @Nature suggests that fine particulate air pollution may promote the proliferation of existing lung cancer-specific genetic mutations, which leads to increased tumour progression. https://t.co/R4J7wMMdza
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A step forward in understanding the role of air pollution in #LungCancer in never smokers. Congratulations to @WillHilliam @LimEmilia @DrClareWeeden @CharlesSwanton and the #TRACERx team for the publication in @Nature. Check out the tweetorial below for more details ⬇️
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵 https://t.co/q1ICykmVox
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📰 Watch @LimEmilia and @WillHilliam discuss their research on the link between air pollution and lung cancer. The research, funded by @CR_UK, was first presented at @myEsmo congress in Sep 2022 and was published in @nature earlier today. @ucl @CharlesSwanton @SwantonLab
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An absolute honour to work with @WillHilliam @LimEmilia @CharlesSwanton @SwantonLab to decipher HOW air pollution contributes to lung cancer formation in never-smokers – out today in Nature. 🧵1/6🧵 (yes a thread on a thread 🤯)
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵 https://t.co/q1ICykmVox
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