Adrian Isaacs
@isaacs_adrian
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Investigating frontotemporal dementia and motor neuron disease at the UK Dementia Research Institute and UCL Queen Square Institute of Neurology
Joined May 2013
A day in the life of our superstar tech Yash! recorded for @DHSCgovuk .@UKDRI @UCLBrainScience @in2scienceUK.
instagram.com
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Our open access opinion in @Brain1878 on the disappointing C9 ASO trials and next steps to deliver an effective treatment for C9ALS/FTD co-written with @AlexCammack @RubikaBalendra @UKDRI @UCLIoN
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RT @UKDRI: A study led by @isaacs_adrian (UK DRI at @UCLIoN) reveals a protective response in cells to early changes in ALS & FTD🧠 . The re….
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Delighted to see our study led by @milioto_carmelo revealing a neuroprotective ECM signature in C9FTD/ALS published! Thanks to @mndassoc @UKDRI and many others!
nature.com
Nature Neuroscience - C9orf72 ALS/FTD polyGR and polyPR knock-in mice show cortical hyperexcitability and motor neuron loss accompanied by an increase in extracellular matrix proteins in the spinal...
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Brilliant to see former lab member Emma Clayton blazing her own trail!.
Happy @WomenScienceDay!!🥳 🎉 🙌 . Don't miss our new feature with UK DRI Emerging Leader Dr Emma Clayton. In the piece, Dr Clayton discusses her career path, the importance of representation and her passion for public engagement👏 👉. #WomenInScience
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We have a new @lifearc1 funded post-doc position to follow up this work, applications close Feb 6th:.
ucl.ac.uk
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
After failure of ASO trials targeting C9orf72 sense repeats also targeting antisense repeats is now vital. Our new preprint shows a potential approach using CRISPR-CasRx @UKDRI @UCLIoN @AlexCammack
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After failure of ASO trials targeting C9orf72 sense repeats also targeting antisense repeats is now vital. Our new preprint shows a potential approach using CRISPR-CasRx @UKDRI @UCLIoN @AlexCammack
biorxiv.org
The most common genetic cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a G4C2 repeat expansion in intron 1 of the C9orf72 gene. This repeat expansion undergoes...
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Taken together this suggests that getting PUFAs to neurons is important for their beneficial effect. Interventions that can boost neuronal lipid desaturation could therefore provide benefit in FTD/ALS 9/9.
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Feeding C9 flies PUFAs was beneficial but neuronally over-expressing fatty acid desaturase enzymes was much more effective, and the same fatty acid desaturase also reduced stressor-induced toxicity in C9 iPSC-neurons 8/9
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To determine whether this deficit was relevant to neurodegeneration or just a bystander, we took two approaches: feeding C9 flies PUFAs, or over-expressing fatty acid desaturase enzymes only in adult neurons 7/9.
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The signature could be prevented by treating with a C9 ASO and recapitulated by expressing repeats in control lines, showing these lipid changes are driven by the repeat expansion 6/9.
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Remarkably, we saw the same lipidomic signature: a specific decrease in phospholipids containing polyunsaturated fatty acids (PUFAs) 5/9
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To investigate lipid changes we performed lipidomics with @MartinGiera and @rikvanderkant on C9 iPSC-neurons and FTLD brains 4/9.
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The work started when we found that the very same genes involved in lipid and fatty acid synthesis and desaturation were downregulated in a fly model of C9orf72 FTD/ALS and ALS post-mortem spinal cord. 3/9
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Was a brilliant collaboration with @MartinGiera @rikvanderkant and @tammarynlashley with support from @ARUKscientist @cziscience and @UKDRI 2/9.
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Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack 1/9.
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RT @AlzResearchUK: .@isaacs_adrian shares his optimism for new dementia treatments. He & his team of researchers @UKDRI are studying the u….
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RT @UCLQSMNDCentre: We are pleased to announce that the Fourth UCL Queen Square Motor Neuron Disease Centre International Symposium (hybrid….
eventbrite.com
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Excited to be presenting unpublished work at the Lipids in Brain Diseases Symposium @LipidsInBrain in September. Hoping to learn a lot and still time to register:
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