Prof Derek Connolly
@DrDerekConnolly
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Consultant Cardiologist Midland Metropolitan University Hospital & Birmingham City Hospital Also now on BlueSky
Birmingham UK
Joined January 2015
our local BBC midlands news supporting @TheBHF programme to make sure women get better heart attack care https://t.co/dP4dvJRqpK
@cpgale3 @SWBHnhs @ICVS_UoB @CardiologySWBH
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Impact of Baseline GLP-1 Receptor Agonist Use on Albuminuria Reduction and Safety With Simultaneous Initiation of Finerenone and Empagliflozin in Type 2 Diabetes and Chronic Kidney Disease (CONFIDENCE Trial)
diabetesjournals.org
OBJECTIVE. The CONFIDENCE trial demonstrated additive benefits of simultaneous initiation of finerenone, a nonsteroidal mineralocorticoid receptor antagoni
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From a new @TheLancet article today entitled "Health care in the USA: money has become the mission" https://t.co/jAjrsgJ5Zn
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Post-hoc analysis of SYNERGY-NASH trial reveals key insights on #tirzepatide in #MASH patients ✅ MASH resolution linked to greater weight loss (-16% vs -7%) ✅ Fibrosis improvement associated with better glycemic control ✅ Liver fat normalization was key mediator of both
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The largest multinational cohort study conducted to date investigated different classes of antihypertensive drugs and the risk of incident dementia. Conclusion: physicians & patients should consider the reduced risk of all-cause dementia and Vascular Dementia with ARB compared
academic.oup.com
AbstractBackground. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) are first-line antihypertensive drugs for
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⬆️Lp(a) levels are independently associated with subclinical coronary atherosclerosis in ageing endurance athletes and healthy controls even with low conventional CV risk. 👉 Highlights the value of Lp(a) for risk stratification in low-risk populations. https://t.co/KNwiPpOCQK
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Santorini Italy. 55-% use of combo Lipid lowering Tx mostly statins plus ezetimibe with 37 and 44% of pts achieving risk based LDL -C goals. Next iteration of most guidelines like BP and DM should consider FDC as SoC https://t.co/i4oeIJoiT7
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We’re excited to see our Alzheimer’s disease biomarker data from a prespecified substudy in our BROADWAY clinical trial has been peer-reviewed and published in @jpreventionalz1. 🔓 Read the open access article: https://t.co/JLv6GnFDCT
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Statin therapy during pregnancy. Read more in the @EHJ at https://t.co/DsdR8aBFMO
#PregnancyHealth #StatinTherapy #MaternalHealth #PregnancyCare @ESCardio @ESC_Journals
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Sunday afternoon catch up with Consultant Cardiologist Colleagues post ward round and primary angioplasties @MidlandMetUH 24/7 but with coffee breaks @CardiologySWBH @SWBHnhs
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Statin efficacy to decrease #MACE depends on #CAD phenotypes and increases with the extent and severity of disease and in the presence of high-risk plaques. Patients without CAD have no benefit from statin therapy regarding MACE. https://t.co/OUpvgkgOBv
#JACCIMG #cvCAD
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Great to see another great Cardiology Quiz of the Day on MedShr from @drahmedmohsen85 Check it out at https://t.co/UEcUedakhy
@ShrillaB @cpgale3 @aayshacader @mirvatalasnag @TCTMD @mmamas1973 @DrDerekConnolly @medshronline @JanisKPereira @sophiakhattak @samia_tasneem1
medshr.it
Cardio Quiz #67:A 52-Year-Old Woman with Severe Headache and Very High Blood Pressure on MedShr
🫀 Cardiology Quiz of the Day! Severe headache with BP 240/120 and papilloedema; hypertensive emergency, lower blood pressure carefully? Can you crack the case? 🩺 Cast your vote on MedShr🔗 https://t.co/4GDVRRR649
#CardioTwitter #MedTwitter #MedEd
@drahmedmohsen85 @DrAsifQasim
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Using combination lipid-lowering therapy in high-risk patients instead of statin monotherapy could prevent 330,000 deaths globally each year, according to a recent meta-analysis published in Mayo Clinic Proceedings. The findings, drawn from data on over 108,000 patients,
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💔 Triple therapy in HFmrEF/HFpEF — potential long-term gains @mvaduganathan et al 📊 Cross-trial analysis (DELIVER, FINEARTS-HF, PARAGON-HF) • SGLT2i + nsMRA → ↓ CV death or 1st HF event by 31% (HR 0.69) • SGLT2i + nsMRA + ARNI → ↓ risk by 39% (HR 0.61; LVEF <60%) •
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🔥 Incretin therapies & liver outcomes in T2 diabetes Real-world EHR study (150M+ pateints): 📉 Tirzepatide↓ risk of major adverse liver outcomes (MALO) by 47%(HR 0.53) 📉 Semaglutide↓ risk by 19% (HR 0.81) ⚪️ Liraglutide - no significant benefit ➡️ Benefit driven by ↓
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The evolution of plasma cholesterol: Direct utility or a ‘‘spandrel” of hepatic lipid metabolism? 🧬 LDL: Evolution’s Beautiful Mistake What if “LDL” was never meant to exist? ☝️LDL is not a product of evolutionary design, but an accident of hepatic lipid metabolism — a
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is this the future of drug trials in our war against atherosclerosis? non invasive testing of how obiceptrapib reduces coronary inflammation and plaque volume https://t.co/1CTmNmdt2r
fiercebiotech.com
Caristo Diagnostics, which uses artificial intelligence to detect the earliest signs of heart disease on cardiac CT scans, will play a major role in an upcoming study of NewAmsterdam Pharma’s chole |...
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Algorithm for #resmetirom treatment from the Global Consensus Recommendations for MASLD and MASH. https://t.co/O3OqWGNvhB
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Obesity in older adults is rising, and semaglutide & tirzepatide can bring significant weight loss and better heart, liver, and kidney health. Risks for older adults are muscle loss and functional decline. Policy must prioritize coverage + clinical trials for seniors to ensure
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Today is World Thrombosis Day — a global reminder to raise awareness about blood clots and their prevention: #WorldThrombosisDay @LHCHFT @LivHPartners
https://t.co/jv1C5CQoUT
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Multi-society consensus guidelines have stated there is no need to routinely hold GLP-1 prior to procedures. Here is another real-world analysis again showing the lack of any increased peri-procedure adverse events.
A large retrospective analysis found that GLP-1 receptor agonist use was not associated with increased risk of aspiration pneumonia, respiratory failure, mechanical ventilation, or hospitalization following screening colonoscopy. https://t.co/P2Khdk9unl
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