Joshua C. Doloff
@DoloffLab
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Doloff Lab: Immunoengineering & Regen Med @TTECJHU | Ugrad @Penn @PennBioeng | PhD @BU_Tweets | Postdoc @MIT | Assoc. Prof. @JohnsHopkins @JHUBME DEI FLI YNWA!
Baltimore, MD
Joined October 2018
Don’t forget, if you’re mulling it over, @SFBiomaterials 2026 (March 25-28, Atlanta) has an extended abstract submission deadline of Nov 21st: https://t.co/EWt7AWY0uW! And where to submit: https://t.co/n51z8vvsj6
@SFBImmuneEng @SFBDrugDelivery
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We have written two reviews providing a practical guide and fundamentals of cell migration: (1) How to select an optimal cell migration assay, (2) How to analyze cell migration data. We also added a perspective on AI methods of analysis. Coming out soon in Nature Methods.
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Nature research paper: Multi-omic profiling reveals age-related immune dynamics in healthy adults https://t.co/lKMBA976WE
nature.com
Nature - This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes...
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Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity https://t.co/iqE2iMnho2
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Come work with us! We are looking for a Sr. Administrative Manager and you can learn more about the role here: https://t.co/YSYX2ekvrT
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We posted this preprint to @biorxiv_immuno that focuses on the idea that CD8 T cells can naturally survey and eliminate stem-cells in the colon epithelium that have neoantigens that are created by somatic mutation. This work was spearheaded by Jess Buck in the lab!
CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon https://t.co/10izGVNlt0
#biorxiv_immuno
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A surprise bonus from COVID-19 vaccines: bolstering cancer treatment | Science | AAAS
science.org
Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer
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Check out our newest student spotlight on 2026 Siebel Scholar, Yining Zhu, and learn more about his research on how to better design lipid nanoparticles, that can carry genetic instructions (like mRNA) into the body to help treat diseases such as cancer. https://t.co/fgvoJjkNvh
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The secret to the naked mole-rats’ extraordinarily long life may lie in subtle changes to just four amino acids, researchers report in Science. https://t.co/KtzxnmH3nX
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Congrats again to all the awardees including our amazing @DoloffLab member Jessica Stelzel, Mao lab member and collaborator (& former TA) Yining Zhu, and @deniswirtz lab member (and newest collaborator) André Forjaz! You are all heavy hitters and rock stars! 🌟
Four #HopkinsBME doctoral students have been named 2026 Siebel Scholars, an honor that recognizes students in bioengineering fields for outstanding achievement in academia, research, and leadership.
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HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer https://t.co/BXqMfuxxjM
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Our October issue is live! 🥳 https://t.co/RcmU6aV61O On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: https://t.co/Jj6TpEtxlK
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The accepted dogma for dietary lipids was their absorption by the gut lining into our bloodstream. It turns out there's another way in, via our immune cells, influenced by the gut microbiome (as shown in mice) @ScienceMagazine
https://t.co/Knvh8g9BjM
https://t.co/15UXOG7tAI
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This tiny device can shrink dangerous blood clots. Researchers at Stanford have developed a new technology that is more than twice as effective as current techniques. It’s called the ‘milli-spinner’ and it was invented by chance. https://t.co/4TLLuIg9lC
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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CAR T therapy has seen great effectiveness in liquid tumors, but little in solid tumors (e.g. ovarian cancer). Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (green = CAR TV cells) Read it here: https://t.co/RR9brDqafP
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We have developed a new workflow to map in 3D at single-cell resolution whole human organs. Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment. More here: https://t.co/UoTgbRKGT0
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This is what the human fallopian tube looks like as one travels through its different sections. We have developed a new 3D single-cell tissue mapping workflow to automatically/accurately detect ovarian cancer precancerous lesions (STICs). More here: https://t.co/UoTgbRKGT0
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Amazing news. Congrats to all awardees, including @DoloffLab’s very own Jessica Stelzel. Shoutout to Mao Lab’s Yining Zhu and @deniswirtz lab’s André Forjaz as well! https://t.co/IsRkxnRC45
@JHUBME @INBT_JHU @TTECJHU @HopkinsEngineer @HopkinsMedicine @JHUMaterials
businesswire.com
The Siebel Scholars Foundation today announced the recipients of the 2026 Siebel Scholars award. Now in its 25th year, the Siebel Scholars program annually r...
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