Mike Mitchell @MJMitchell_Lab profile

Mike Mitchell

@MJMitchell_Lab

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https://t.co/8WiROUo1c7

University of Pennsylvania

Joined August 2011

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Mike Mitchell

@MJMitchell_Lab

4 months

Thrilled to share our latest in Nature Biomedical Engineering @natBME led by @MJMitchell_Lab Postdoc Ningqiang Gong on a "switchable" bispecific T cell engager to eliminate solid tumors in a safer manner! Study: @Penn news story:

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Mike Mitchell

@MJMitchell_Lab

1 year

Super excited to be awarded tenure @Penn ! Huge thanks to lab members, colleagues @pennbioeng , and letter writers for making this possible. It’s been an honor to watch @MJMitchell_Lab open in Summer 2018 and grow to 40+ members. So proud of the team and the best is yet to come!

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Mike Mitchell

@MJMitchell_Lab

2 years

Rest In Peace to my brilliant, beautiful, fearless Mom. You came from 🇦🇷 to 🇺🇸 to start a new life, swept my Dad off his feet on a blind date, and pushed Marc and I to reach heights we never thought possible. My lab and I will cure this disease in your honor. I love you Mom.

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Mike Mitchell

@MJMitchell_Lab

2 years

Excited to launch the @Penn Institute for RNA Innovation directed by @WeissmanLab and serve as the Lipid Nanoparticle (LNP) Delivery Systems Group Leader! We look forward partnering w academia + industry to develop transformative RNA delivery tech! Link:

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Mike Mitchell

@MJMitchell_Lab

2 years

Honored to receive the Young Investigator Award from @SFBiomaterials , my home society that's supported me since I was a student! Huge thanks to @BurdickLab @profmikeking Bob Langer for nominating me + the @MJMitchell_Lab team that make this the dream job!

Michael Mitchell receives the 2022 SFB Young Investigator Award - Penn Engineering Blog

Michael Mitchell, Skirkanich Assistant Professor of Innovation in the Department of Bioengineering, has been awarded the 2022 Society for Biomaterials (SFB) Young Investigator Award for … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

2 years

Excited to announce that our lab has received an @NSF CAREER Award! Led by @MJMitchell_Lab PhD student @AlvMukalel , we will create new mRNA lipid nanoparticle tech to engineer macrophages for solid tumor immunotherapy. We are hiring postdocs + PhD students at #SFB2022 this week!

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Mike Mitchell

@MJMitchell_Lab

8 months

Huge congrats to our friends @WeissmanLab @kkariko for winning the @NobelPrize for the COVID-19 mRNA vaccines! Will never forget the day Drew knocked on my door when I started @pennbioeng in 2018 and asked to collaborate on new LNP technology. Thank you for being a great mentor!

The Nobel Prize

@NobelPrize

8 months

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

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Mike Mitchell

@MJMitchell_Lab

4 years

Congrats to my PhD student ⁦ @mag_youre_it ⁩ on her nano CAR T immunotherapy study ⁦ @NanoLetters ⁩ making ⁦⁦ @Penn ⁩’s front page! Maggie was the 1st PhD to join me - not sure why she chose me - but I’ll never forget it #WomenInSTEM #newpi

Penn nanoparticles are less toxic to T cells engineered for cancer immunotherapy | Penn Today

By using messenger RNA across the T cell’s membrane via a nanoparticle instead of a DNA-rewriting virus on extracted T cells, CAR T treatments could have fewer side effects.

penntoday.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

1 year

Thrilled to share our latest in Nature Nanotechnology @NatureNano led by @MJMitchell_Lab Postdoc Fellow @Xuexiang_Han in collaboration with @WeissmanLab on a new class of adjuvant lipidoids that augment the immunogenicity of SARS-CoV-2 mRNA LNP vaccines!

Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA...

Nature Nanotechnology - A lipid nanoparticle (LNP) component—an adjuvant lipidoid—is developed to enhance the adjuvanticity of LNPs, which significantly increases the innate and...

www.nature.com

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Mike Mitchell

@MJMitchell_Lab

1 year

Super excited to share our latest in Nature Communications @NatureComms led by @MJMitchell_Lab postdocs @Xuexiang_Han @NingqiangGong on a new ligand tethered LNP platform to unlock RNA delivery to activated fibroblasts to treat liver fibrosis! Paper link:

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Mike Mitchell

@MJMitchell_Lab

9 months

Thrilled to share our latest in @NatureMaterials led by @MJMitchell_Lab Postdoc Fellow Ningqiang Gong on creating CAR T cell biomaterial coatings in the body for potent cancer immunotherapy without toxic side effects! Free access:

A suit of armor for cancer-fighting cells | Penn Today

New research from the University of Pennsylvania offers a safer path for CAR T cell immunotherapy.

penntoday.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

9 months

Thrilled to be named a Young Innovator by @CMBEjournal and share our latest work led @MJMitchell_Lab PhD student @CGFigE on a new RNA nanoparticle combination therapy to treat multiple myeloma! Free access to the study:

Bioengineering Faculty Member Named ‘Young Innovator’ for Creation of Multiple Myeloma Therapy -...

Michael J. Mitchell, Associate Professor in Bioengineering at the University of Pennsylvania School of Engineering and Applied Science, has been named a “Young Innovator of Cellular … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

10 months

We are hiring junior and senior faculty this year @pennbioeng ! Research areas of interest include biomaterials, drug delivery, cell & tissue engineering, AI, and synbio. Join us in our new beautiful UCity building! Link to apply (deadline November 21):

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Mike Mitchell

@MJMitchell_Lab

4 years

Check out our latest ⁦ @natBME - we show how nanoparticles that deliver RNA to bone marrow can treat heart attack, mobilize stem cells for transplants: V lucky to collab+learn *tons* from ⁦⁦ @MatthiasNahrend ⁩ + his team!

Nanoparticles can turn off genes in bone marrow cells

Using nanoparticles, MIT engineers have developed a way to turn off specific genes in the cells found in bone marrow, which plays an important role in producing blood cells. These particles could be...

news.mit.edu

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Mike Mitchell

@MJMitchell_Lab

3 months

Thrilled to share our latest in Nature Communications @NatureComms led by @MJMitchell_Lab Postdoc @Lulu_Xuee on new cationic degradable lipid nanoparticles for antiangiogenic mRNA lung cancer therapy! Study: @Penn news story:

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Mike Mitchell

@MJMitchell_Lab

8 months

Mitchell Lab is off to Seattle to give 17 presentations at #BMES2023 , including 10 talks on mRNA LNP technology for immunotherapy, pregnancy, brain delivery, gene editing, and more! We are also hiring Postdocs and PhD students, please come chat with the team if interested!

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Mike Mitchell

@MJMitchell_Lab

3 years

Check out our latest ⁦ @ScienceAdvances ⁩ on engineering lipid nanoparticles for therapeutic mRNA delivery before birth (in utero) in collaboration with the ⁦⁦ @WPeranteau ⁩ ⁦⁦⁦lab @ChildrensPhila ⁩! Link:

Penn Engineering and CHOP Researchers Identify Nanoparticles that Could Be Used in Therapeutic mRNA...

Researchers at Children’s Hospital of Philadelphia and the School of Engineering and Applied Science at the University of Pennsylvania have identified ionizable lipid nanoparticles that … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

2 years

9 presentations and 9000 tacos later, @MJMitchell_Lab is closing out #BMES2022 with a joint group photo with our favorite lab from the south @veiseho @Rice_BIOE ! Super proud of this crew and excited to see all their hard work published in the coming months!

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Mike Mitchell

@MJMitchell_Lab

6 years

Really excited for my young team @Penn @pennbioeng today - thank you @NIH_CommonFund @ncats_nih_gov for selecting us to receive the @NIHDirector ’s New Innovator Award. The lab is only months old, but we’re up for the task of #NIHHighRisk research!

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Mike Mitchell

@MJMitchell_Lab

1 month

Honored to receive the Controlled Release Society Young Investigator Award, my home society! Even better to win it with friend @rvdmnanomeds . Huge thanks to Bob Langer for the nomination + @MJMitchell_Lab @pennbioeng for crushing it since 2018! Link:

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Mike Mitchell

@MJMitchell_Lab

1 year

Super excited to share on #InternationalWomensDay our latest in Nature Reviews Bioengineering @natrevbioeng led by rising star @MJMitchell_Lab PhD student Kelsey Swingle @SwingleKelsey on drug delivery tech tailored for women’s health applications! Link:

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Mike Mitchell

@MJMitchell_Lab

2 years

Check out our latest in Nature Nanotechnology @NatureNano with friends @WeiTaoLab and @peer_lab on nanotech strategies against SARS-CoV-2 variants! Amazing team effort led by our rockstar postdocs Xuexiang Han @Sean2354H @XiangangHuang @Edo_Kon

Nanotechnology-based strategies against SARS-CoV-2 variants

Nature Nanotechnology - This Perspective highlights the role that nanotechnology might play in tackling the rise of new SARS-CoV-2 variants.

www.nature.com

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Mike Mitchell

@MJMitchell_Lab

2 years

Big thanks to @PennEngineers @pennbioeng for featuring our recent @NSF CAREER Award on new mRNA LNP tech for engineering macrophages to target and kill solid tumors! We will be hiring postdocs and PhD students for our immunoengineering projects at #BMES2022 in two weeks!

Penn Bioengineering

@pennbioeng

2 years

Not one but two NSF CAREER Awards for #PennBioengineering faculty in 2022! Our hearty congratulations to Mike Mitchell, who received this award for his research in immunoengineering. @MJMitchell_Lab #BioEngineering #BioMedicalEngineering #Immunology

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Mike Mitchell

@MJMitchell_Lab

1 year

Amazing Mechanisms and Barriers in Nanomedicine workshop with @AviSchroeder @NatalieArtzi @TheChanLab @pgdecuzzi @AnnaSchwendy @peer_lab @JulieNguyenLab @twan_lammers out west in Colorado! Also found old friend @BurdickLab and Parker up in the mountains!

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Mike Mitchell

@MJMitchell_Lab

2 years

Check out our latest @ScienceAdvances focus article by @MJMitchell_Lab PhD students Ann Metzloff + @MagBillingsley on @gabekwong 's new tech using light to create lipid nanoparticles that deliver mRNA to disease-specific T cells in the body - link:

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Mike Mitchell

@MJMitchell_Lab

7 months

Huge congrats to @MJMitchell_Lab PhD student Ajay Thatte @ASThatte2 for being featured on the cover of @NanoLetters for his new mRNA lipid nanoparticle tech to engineer T cells to treat autoimmune diseases! Issue link: Article link:

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Mike Mitchell

@MJMitchell_Lab

2 years

Not a bad place to get bioinspired about materials @GordonConf

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Mike Mitchell

@MJMitchell_Lab

2 years

Elected #GRSDrugCarriers Chair, Postdoc offers, and now the GRC best poster award for @MJMitchell_Lab PhD student @MagBillingsley to cap off #DCMB2022 ! Thank you @SuziePun @SMitragotri for a killer #GRCDrugCarriers and excited for #DCMB2024 with @KWhiteheadLab @vadimdudkin !

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Mike Mitchell

@MJMitchell_Lab

4 years

We are hiring tenure-track faculty at all levels @pennbioeng - research areas of interest include synthetic biology, imaging, bioinformatics, neuroengineering, nanobiotech, and regenerative medicine. Please spread the word!

Penn Bioengineering

@pennbioeng

4 years

The Department of #PennBioengineering is engaged in a multi-year effort to fill tenure-track and tenured positions at the Assistant, Associate and Full Professor levels. Find out more info and apply: #bioengineering #highered

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Mike Mitchell

@MJMitchell_Lab

2 years

Check out our latest @NatureComms led by superstar @pennbioeng @MJMitchell_Lab Postdoc Xuexiang Han @Sean2354H and Hanwen Zhang with great help from @SwingleKelsey @WeissmanLab on an ionizable lipid “toolbox” for RNA delivery! Free access:

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Mike Mitchell

@MJMitchell_Lab

5 months

Excited to share our latest work in @NanoLetters led by rising star @MJMitchell_Lab PhD student Emily Han @_emilyhan_ on a predictive screening platform for mRNA lipid nanoparticle delivery to the brain! Study: @Penn press release:

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Mike Mitchell

@MJMitchell_Lab

11 months

Check out our latest @acsnano with @WPeranteau 's lab led by our MD PhD student @rohan_palanki on new mRNA LNPs for in utero and postnatal base editing in the brain to treat congenital disorders! Rohan is presenting his work at GRC Biomaterials this week!

Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease

Delivery of mRNA-based therapeutics to the perinatal brain holds great potential in treating congenital brain diseases. However, nonviral delivery platforms that facilitate nucleic acid delivery in...

pubs.acs.org

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Mike Mitchell

@MJMitchell_Lab

11 days

A big happy 27th birthday to the master of backpacks @SMitragotri !! #wbc2024

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Mike Mitchell

@MJMitchell_Lab

3 years

Check out our latest ⁦ @NanoLetters ⁩ on engineering a new microfluidic platform to manufacture mRNA lipid nanoparticles across all scales of development in collaboration with the ⁦⁦⁦ @DavidIssadore ⁩ lab! Link:

With a ‘Liquid Assembly Line,' Penn Researchers Produce mRNA-Delivering Nanoparticles a Hundred...

The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

5 years

Please retweet! My lab is hiring multiple postdocs for 3 new collaborative NIH grants w friends @ChildrensPhila @parkerici @sloan_kettering @Penn_IFI . If at #BMES2019 , pls connect w lab members @Rach_Riley27 @mag_youre_it @CGFigE at our @pennbioeng reception. Cheesesteaks on us!

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Mike Mitchell

@MJMitchell_Lab

3 years

Pumped to see ⁦my ⁦ @pennbioeng ⁩ PhD student ⁦ @MagBillingsley ’s⁩ CAR T mRNA lipid nanoparticle work featured as @Penn establishes a new $100 million Center for Precision Engineering for Health to develop novel therapeutic biomaterials!

Penn establishes the Center for Precision Engineering for Health with $100 million commitment |...

The Center will conduct interdisciplinary, fundamental, and translational research in biomaterials that can create breakthroughs in improving health care and saving lives, including nanoparticle...

penntoday.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

5 months

Check out our latest collaborative work in Nature Communications @NatureComms led by our friend Pedro Guimaraes's lab on high-throughput in vivo screening of lipid nanoparticles to identify potent new COVID-19 DNA vaccines! Free access:

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Mike Mitchell

@MJMitchell_Lab

4 years

Congrats to my superstar @pennbioeng PhD student @mag_youre_it for being awarded a NIH T32 fellowship in HIV Pathogenesis, Vaccination, and Cure! Maggie is using her latest CAR T cell tech to treat HIV:

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Mike Mitchell

@MJMitchell_Lab

5 months

Thrilled to announce that @MJMitchell_Lab team captain Dr. Ningqiang Gong is launching his lab at top ranked University of Science and Technology of China! Check out Ningqiang’s recent CAR T @NatureMaterials paper, and be on the lookout for more in 2024:

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Mike Mitchell

@MJMitchell_Lab

1 year

Super excited to share our latest in PNAS @PNASNews led by @MJMitchell_Lab PhD student Chris Figueroa-Espada @CGFigE and Pedro Guimaraes on a new RNA nanoparticle bone marrow therapy to treat multiple myeloma! Link to paper:

RNA Nanoparticle Therapy Stops the Spread of Incurable Bone Marrow Cancer - Penn Engineering Blog

Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

2 months

Thrilled to announce that @MJMitchell_Lab 's own "X-man" Dr. @Xuexiang_Han is launching his lab at Shanghai Institute of Biochemistry and Cell Biology! Check out X-man's @NatureNano @NatureComms papers, with more to come in 2024:

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Mike Mitchell

@MJMitchell_Lab

2 years

Excited for the new school year at @Penn and to kickoff year 5 of @MJMitchell_Lab at @pennbioeng with these rockstar students + fellows! Be on the lookout for their latest mRNA LNP tech for cancer immunotherapy, vaccines, gene editing + fetal-maternal health coming out this year!

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Mike Mitchell

@MJMitchell_Lab

3 years

Check out our latest ⁦ @NatureNano ⁩ on Nanomaterials for T-cell cancer immunotherapy by ⁦ @NingqiangGong ⁩ ⁦ @MagBillingsley ⁩ ⁦ @pennbioeng ⁩ + ⁦ @carlhjune ⁩ + N Sheppard ⁦⁦ @PennCancer ⁩! Free access:

Nanomaterials for T-cell cancer immunotherapy

Nature Nanotechnology - This Review discusses the progress and the remaining challenges for the clinical application of nanomaterial-based T-cell immunotherapies.

www.nature.com

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Mike Mitchell

@MJMitchell_Lab

10 months

Check out our latest paper published in Small @AdvSciNews led by @MJMitchell_Lab PhD student Hannah "Coach" Safford @hannahsafford_ on orthogonal design of experiments LNP optimization for in vivo mRNA delivery to the placenta during pregnancy! Link:

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Mike Mitchell

@MJMitchell_Lab

3 years

Herd immunity unlocked @MJMitchell_Lab , bring on summer!

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Mike Mitchell

@MJMitchell_Lab

3 years

Honored to receive the Journal of Nanobiotechnology Rising Star Award, thanks @QuanyinHu_Lab and @WeiTaoLab for the nomination! Fortunate to be part of such a supportive research community and for the rockstar @MJMitchell_Lab labbies that go hard everyday

Wei Tao

@WeiTaoLab

3 years

Congrats to the winners of our 2021 Rising Star Awards @MJMitchell_Lab and Daishun Ling. This inaugural award recognizes talented young researchers who have made outstanding contributions in the field of nanobiotechnology and nanomedicine.

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Mike Mitchell

@MJMitchell_Lab

1 year

Check out our latest in Nature Biomedical Engineering @natBME by @MJMitchell_Lab Postdoctoral Fellow Ningqiang Gong @NingqiangGong + PhD student Alex Hamilton @a_hmltn on Ruikang Tang's new hydrogel-entrapped live virus immunization platform! Free access:

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Mike Mitchell

@MJMitchell_Lab

2 years

Mitchell Lab is San Antonio bound in search of tacos and science at #BMES2022 ! Check out 5 talks by @rohan_palanki @NingqiangGong @a_hmltn @SwingleKelsey + 4 posters by @SavanKPatel @Xuexiang_Han @Lulu_Xuee . We are also recruiting Postdocs + PhD students, come chat if interested!

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Mike Mitchell

@MJMitchell_Lab

5 months

Check out our latest Nature Cancer @NatureCancer News and Views led by @MJMitchell_Lab PhD student Alex Hamilton @a_hmltn on Shawn Chen lab's new class of oncolytic circular RNA therapeutics for treating adenocarcinomas! Free access:

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Mike Mitchell

@MJMitchell_Lab

1 year

Check out our latest publication in Small @AdvSciNews co-led by @MJMitchell_Lab PhD students Hannah Geisler @HannahGeisler_ + Hannah Safford @hannahsafford_ on rational design of nanomedicine for women's reproductive health applications! Link to article:

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Mike Mitchell

@MJMitchell_Lab

8 months

Beyond proud of the @MJMitchell_Lab team (aka the 5-0 @Eagles according to ChatGPT @profmikeking @CMBEjournal ) for a stellar 4 quarters of play and going 17-0 on #BMES2023 presentations! Thank you @BMESociety for a fantastic meeting and looking forward to #BMES2024 in Baltimore!

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Mike Mitchell

@MJMitchell_Lab

3 years

Check out our latest “strategy of the month” @TrendsMolecMed by my amazing first year @pennbioeng PhD students @SwingleKelsey @a_hmltn on lipid nanoparticle delivery of mRNA therapeutics and vaccines! Free access:

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Mike Mitchell

@MJMitchell_Lab

3 years

Reinforcements have arrived! Pumped to welcome 3 new @pennbioeng PhD students and @NSF Graduate Research Fellows to @MJMitchell_Lab : Ann Metzloff @Cornell_CBE , Hannah Geisler @PittBioE , and Hannah Safford @hannahsafford_ @kochinstitute !

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Mike Mitchell

@MJMitchell_Lab

1 year

Super excited to announce that the PhD defense of the first @MJMitchell_Lab PhD student Maggie Billingsley titled "Ionizable LNPs for mRNA CAR T Cell Engineering" is one week from today! - Friday December 16 2pm ET - Room: Towne 337 - Zoom: msg @MagBillingsley for link

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Mike Mitchell

@MJMitchell_Lab

6 months

Amazing keynote lecture by friend @KWhiteheadLab on lipid nanoparticle mRNA delivery to the pancreas to kick off our @Penn CT3N nanomedicine symposium! Fun fact: Katie not only gives great RNA delivery advice, but also teaches us how to grow killer tomato gardens over dinner!

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Mike Mitchell

@MJMitchell_Lab

7 months

Check out our latest research in Nano Letters @NanoLetters led by @MJMitchell_Lab PhD student Ajay Thatte @ASThatte2 on new mRNA LNP tech to develop immunosuppressive T cells for autoimmune therapies!

Lipid Nanoparticles That Deliver mRNA to T Cells Hold Promise for Autoimmune Diseases - Penn...

Ajay Thatte, Benjamin Nachod, Rohan Palanki, Kelsey Swingle, Alex Hamilton, and Michael Mitchell (Left to Right – Courtesy of the Mitchell Lab) Autoimmune disorders are … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

11 months

Going through @MJMitchell_Lab manuscript revisions, and will gladly take on reviewer revision requests like this any day of the week:

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Mike Mitchell

@MJMitchell_Lab

1 year

Huge congrats to @MJMitchell_Lab PhD student Kelsey Swingle @SwingleKelsey on being selected for cover of this month's issue of @J_A_C_S for her new mRNA lipid nanoparticle technology for pregnancy! Link to issue: Link to article:

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Mike Mitchell

@MJMitchell_Lab

3 months

Excited to share our latest in Nature Communications @NatureComms led by @MJMitchell_Lab Postdoc @Xuexiang_Han on space shuttle-inspired lipid nanoparticle design for mRNA gene editing and treating obesity! Study: @Penn news story:

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Mike Mitchell

@MJMitchell_Lab

4 years

Thanks @SMitragotri for the shout out! Check out our latest @NatRevDrugDisc on precision nanoparticles for drug delivery, amazing effort by @mag_youre_it + Reba Haley @pennbioeng , Marissa Wechsler + @NPeppas @UTBiomedical , + Bob Langer @MIT . Huge thx to @megan_cully for editing!

Samir Mitragotri

@SMitragotri

4 years

A must read paper from @NPeppas Bob Langer, @MJMitchell_Lab and co-authors in nature reviews drug discovery on precision nanoparticles

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Mike Mitchell

@MJMitchell_Lab

2 years

Check out our latest on the cover of today’s issue of @NanoLetters led by @MagBillingsley in collaboration w @carlhjune ’s lab on orthogonal DOE methodology to create new mRNA lipid nanoparticles for engineering CAR T cells for cancer immunotherapy! Link:

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Mike Mitchell

@MJMitchell_Lab

6 months

Check out our latest in Nature Reviews Materials @NatRevMater led by @MJMitchell_Lab Postdoc @Lulu_Xuee + PhD student @ASThatte2 in collaboration with @Karin_Wang26 @carlhjune on responsive biomaterials to optimize control of cancer immunotherapy! Link:

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Mike Mitchell

@MJMitchell_Lab

3 months

Check out our latest in Advanced Functional Materials @AdvSciNews led by @MJMitchell_Lab PhD student Alvin Mukalel @AlvMukalel on new oxidized mRNA lipid nanoparticle tech for making CAR monocytes in the body for cancer immunotherapy! Free access:

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Mike Mitchell

@MJMitchell_Lab

1 year

Super excited to share our latest in @J_A_C_S led by superstar @MJMitchell_Lab PhD student Kelsey Swingle @SwingleKelsey on a new LNP platform to unlock placental cell mRNA delivery to develop a range of new prenatal therapeutics for pregnant mothers!

Targeted Prenatal Therapy for Mothers and Their Babies Addresses Longstanding Gap in Health Equity...

New research on reproductive health demonstrates the first successful delivery of mRNA to placental cells to treat pre-eclampsia at its root. Pre-eclampsia is a leading … Read More ›

blog.seas.upenn.edu

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Mike Mitchell

@MJMitchell_Lab

3 years

We are hiring multiple postdocs and PhD students @MJMitchell_Lab and will be *in person* at #BMES2021 ! Check out talks by our @pennbioeng students @MagBillingsley Sarah Shepherd @SwingleKelsey + Savan Patel on mRNA, LNPs, microfluidics, immunoengineering, women’s health + more!

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Mike Mitchell

@MJMitchell_Lab

1 year

Huge congrats to Dr. Maggie Billingsley @MagBillingsley on a successful PhD defense! It was a privilege to have you as our first PhD student and build @MJMitchell_Lab from the ground up with you. We look forward to having a front row seat to the exciting things you’ll accomplish!

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Mike Mitchell

@MJMitchell_Lab

2 years

Super pumped and grateful to receive a @WellcomeLeap Award from their RNA Readiness and Response R3 program and team up with friends @DavidIssadore @WeissmanLab and Daeyeon Lee to develop on- demand manufacturing tech that can produce mRNA LNP vaccines!

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Mike Mitchell

@MJMitchell_Lab

4 years

Congrats to my @pennbioeng postdoctoral fellow Dr. Rachel Riley @Rach_Riley27 for winning a prestigious @NIH @theNCI F32 fellowship! Dr. Riley will continue her cancer nanomedicine research in the lab before joining @RowanRCE as an Assistant Professor of Biomedical Engineering

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Mike Mitchell

@MJMitchell_Lab

2 years

Huge congrats to @MJMitchell_Lab PhD student Maggie Billingsley @MagBillingsley for being elected Chair of the next Gordon Research Seminar on Drug Carriers in Medicine and Biology! @SwingleKelsey ran a flawless election campaign. We will celebrate at #GRCDrugCarriers this week!

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Mike Mitchell

@MJMitchell_Lab

2 years

First trip to Korea (Seoul and Daejeon) to present the latest research from the @MJMitchell_Lab team and kickstart our new 8 year grant with the Korea Research Institute of Bioscience and Biotechnology on new mRNA LNP vaccine tech! We are hiring postdocs and PhD students!

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Mike Mitchell

@MJMitchell_Lab

16 days

Check out our latest perspective in @acsnano with @NatalieArtzi @TheChanLab @twan_lammers @peer_lab @JulieNguyenLab @AviSchroeder @AnnaSchwendy and more on mechanisms and barriers in nanomedicine, based off an amazing Colorado workshop by Dmitri Simberg!

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions

In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting in several approved drugs and multiple promising candidates in clinical trials....

pubs.acs.org

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Mike Mitchell

@MJMitchell_Lab

3 years

Proud of the @MJMitchell_Lab lab crew for leaving everything on the field and giving excellent talks + posters at #BMES2021 ! We’re a little exhausted, but excited to get back @pennbioeng and prep for #BMES2022 . Huge thanks to co-chairs @peytonlab @DrPlattLab for a great meeting!

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Mike Mitchell

@MJMitchell_Lab

3 years

“To be a scientist is a joy.” - @kkariko Looking forward to @WeissmanLab and @kkariko locking down the @NobelPrize this week, all of us at @Penn and across the world are rooting for you!

Penn Medicine

@PennMedicine

3 years

Congrats to #LaskerAward winners Drew Weissman & Katalin Kariko, @PennMedicine mRNA vaccine pioneers! Their revolutionary work not only set the stage for development of the COVID vaccines, but it’s also showing us what the future of medicine may look like.

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Mike Mitchell

@MJMitchell_Lab

4 months

Thrilled to share our latest collaborative work with @vaughandy 's lab in PNAS @PNASNews led by @zhao_gan and @MJMitchell_Lab Postdoc @Lulu_Xuee on new intranasal macrophage-targeted RNA lipid nanoparticle technology to treat viral pneumonia! Study:

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Mike Mitchell

@MJMitchell_Lab

3 years

Congrats to my superstar @pennbioeng PhD students @MagBillingsley + Sarah Shepherd for winning @SFBiomaterials STAR awards! Check out their oral presentations on in utero mRNA delivery and scalable mRNA LNP production next week at the SFB annual meeting:

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Mike Mitchell

@MJMitchell_Lab

5 months

Great mentors are your mentors for life. Congrats @profmikeking on the @BMES_CMBE Chris Jacobs Leadership Award and @NPeppas on the Shu Chien Lifetime Achievement Award! @Karin_Wang26 and I are so grateful for your support - we will pay it forward to our trainees. #CMBE2024

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Mike Mitchell

@MJMitchell_Lab

3 years

Huge congrats to @MJMitchell_Lab @pennbioeng Postdoc Marshall Padilla and PhD student @MagBillingsley on winning NIH T90 and F31 fellowships to support their mRNA LNP research!

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Mike Mitchell

@MJMitchell_Lab

1 year

Huge congrats to @MJMitchell_Lab alum @MagBillingsley for receiving the Solomon R. Pollack Award, given to the most deserving @pennbioeng PhD student who completed their thesis! Maggie developed new mRNA LNP CAR T cell tech and is now crushing it as a Postdoc @kochinstitute !

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Mike Mitchell

@MJMitchell_Lab

1 year

Interested in setting up mRNA lipid nanoparticle formulation + in vitro/in vivo testing in your lab or company from scratch? Check out our latest in @JoVEJournal led by Rakan El-Mayta, Marshall Padilla @MagBillingsley @Xuexiang_Han , video coming soon!

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Mike Mitchell

@MJMitchell_Lab

2 years

Big congrats to our 1st year @MJMitchell_Lab PhD students @hannahsafford_ + @ASThatte2 for passing their PhD qualifying exams! Thanks to @ProfDAHammer @kiranmusunuru @WPeranteau for the excellent discussion, and to @jboerckel for having them whip out equations on the whiteboard!

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Mike Mitchell

@MJMitchell_Lab

1 year

Check out our latest work in @ACS_AMI led by @MJMitchell_Lab PhD student Rebecca Haley + @ScienceAndSushi from the Tsourkas lab on a new lipid nanoparticle platform for intracellular protein delivery of RAS inhibitors for in vivo cancer therapy! Link:

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Mike Mitchell

@MJMitchell_Lab

2 years

Honored and grateful to receive the @SFBiomaterials Young Investigator Award! Will pay it forward by training the next gen of biomaterials scientists and engineers, and working with the squad @MagBillingsley @SwingleKelsey @SavanKPatel to bring mRNA LNP therapeutics to patients!

Karin Wang

@Karin_Wang26

2 years

Congrats to @MJMitchell_Lab for receiving the @SFBiomaterials Young Investigator Award!! 🤩🥳

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Mike Mitchell

@MJMitchell_Lab

3 months

Check out our latest in Advanced Materials @AdvSciNews led by @MJMitchell_Lab PhD student Ann Metzloff on antigen presenting cell-mimetic lipid nanoparticles for rapid mRNA CAR T cell cancer immunotherapy! Free access: @Penn story:

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Mike Mitchell

@MJMitchell_Lab

10 months

Thrilled to share our latest in PNAS @PNASNews led by Sarah "Scaleup" Shepherd (co-advised with @DavidIssadore ) on SCALAR: a new microfluidic platform for throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines! Free access link:

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Mike Mitchell

@MJMitchell_Lab

2 years

Happy holidays from COVID-19’s worst nightmare - a legion of @pennbioeng @MJMitchell_Lab bioengineers armed to the teeth with mRNA LNPs

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Mike Mitchell

@MJMitchell_Lab

11 months

Incredible first visit to Japan for the @theNAEng US-Japan Frontiers of Engineering Symposium in Tokyo with colleagues and friends @veiseho @Landry_Lab @SpanglerLab to share our latest on new mRNA LNP tech for extrahepatic delivery + maternal health by @Lulu_Xuee @SwingleKelsey !

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Mike Mitchell

@MJMitchell_Lab

8 months

Prom night-style @veiseho - @Karin_Wang26 - @chorye - @MJMitchell_Lab joint lab shot @dintaifungusa on the eve of #BMES2023 ! Come check out several killer talks and posters from our labs today!

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Mike Mitchell

@MJMitchell_Lab

2 years

Killer talks by @MJMitchell_Lab PhD students @rohan_palanki and Ann Metzloff on mRNA LNP brain gene editing and CAR T cell engineering to kick off #BMES2022 !

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Mike Mitchell

@MJMitchell_Lab

11 months

Incredible first visits to Montana and Wyoming for the @CF_Foundation conference and stunning Yellowstone National Park @YellowstoneNPS ! Great to reconnect with friends and colleagues @DJSiegwart @sahayg1 @TheChanLab @AnnaBlakney @chrisnelsonlab

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Mike Mitchell

@MJMitchell_Lab

5 years

Honored to serve the @SFBiomaterials @SFBDrugDelivery community in the coming years with @veiseho @Rice_BIOE , Ana Jaklenec @kochinstitute , and Ambika Bajpayee @NUBioE1

Penn Bioengineering

@pennbioeng

5 years

#PennBioengineering professor Michael Mitchell @MJMitchell_Lab was recently elected Chair of the #DrugDelivery Special Interest Group for the #SocietyofBiomaterials . Congrats!!

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Mike Mitchell

@MJMitchell_Lab

2 years

Check out our latest in @J_A_C_S led by @MJMitchell_Lab Postdocs @Lulu_Xuee + @NingqiangGong in collaboration with @WeissmanLab @Karin_Wang26 on rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment! Link:

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Mike Mitchell

@MJMitchell_Lab

2 years

Check out our latest @RSCAdvances led by @MJMitchell_Lab postdoc fellows @Lulu_Xuee and Jingya Qin (now @sparktx ) on a new library of RGD peptide lipid-like materials for targeted mRNA delivery and gene editing applications! Link:

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Mike Mitchell

@MJMitchell_Lab

4 years

Congrats to my @pennbioeng PhD students Rebecca Haley and Sarah Shepherd for winning @NSFGRFP fellowships! It’s a privilege to get to do awesome science with these rockstars everyday #WomenInSTEM @PennEngineers

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Mike Mitchell

@MJMitchell_Lab

2 years

Huge congrats to @MJMitchell_Lab Postdoc Dr. @NingqiangGong for winning the BMES Burroughs Young Investigator Award, selected from the top Postdoc + early stage faculty abstracts! Excited for him to unveil his work on biomaterials for safer CAR T cell therapy at @BMESociety 2022!

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Mike Mitchell

@MJMitchell_Lab

3 months

Check out our latest in Journal of Biomedical Materials Research Part A @SFBiomaterials led by @MJMitchell_Lab undergraduate researcher Kaitlin Mrksich on how ionizable lipid tail length influences LNP delivery of mRNA of varying length! Free access:

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Mike Mitchell

@MJMitchell_Lab

7 months

Check out our latest in Theranostics @THNOdotORG led by former @MJMitchell_Lab undergrad Savan Patel @SavanKPatel on a new bile acid lipid nanoparticle platform to enhance mRNA delivery beyond the liver! Free access:

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Mike Mitchell

@MJMitchell_Lab

1 year

Check out our latest in @NatureMaterials by @MJMitchell_Lab Postdoc Ningqiang Gong @NingqiangGong + PhD student Alex Hamilton @a_hmltn on Joshua Jackman + Jae Hyung Park's new exosome-disrupting peptide platform for cancer immunotherapy! Free access:

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Mike Mitchell

@MJMitchell_Lab

2 years

Interested in mRNA + lipid nanoparticle industry jobs? Please tune in to our @CRSScience @CRS_FG_Gene industry webinar Thursday Dec 8th 11am-1230pm EST by industry leaders Cory Sago @cory_sago (formerly @BeamTx ) + Stefaan De Koker ( @eTheRNA_engine ) to learn more! Zoom link below:

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Mike Mitchell

@MJMitchell_Lab

2 months

Huge congrats to @MJMitchell_Lab MD PhD student @rohan_palanki for receiving the Solomon R. Pollack Award, given annually to a @pennbioeng graduate student who has successfully completed research that is original and recognized as being at the forefront of its field!

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Mike Mitchell

@MJMitchell_Lab

9 months

Big thanks to @PennEngineers for featuring our recent work in @NatureNano led by @MJMitchell_Lab postdoc @Xuexiang_Han in collaboration with @WeissmanLab on new adjuvant lipid-like materials that augment the immunogenicity of COVID-19 mRNA LNP vaccines!

An Improved Delivery System for mRNA Vaccines Provides More Powerful Protection - Penn Engineering...

Researchers from the University of Pennsylvania School of Engineering and Applied Science and the Perelman School of Medicine are refining the Covid-19 vaccine, creating an innovative delivery system...

blog.seas.upenn.edu

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