Mike Mitchell
@MJMitchell_Lab
Followers
7K
Following
10K
Media
381
Statuses
3K
Associate Professor of Bioengineering | Lipid Nanoparticles | mRNA Therapeutics & Vaccines | Drug Delivery | Biomaterials | Immunotherapy
Philadelphia, PA
Joined August 2011
Thrilled to share our latest in Nature Biomedical Engineering @natBME led by @MJMitchell_Lab Postdocs Ningqiang Gong @DongyoonKim5 on a Mannich reaction approach to create antioxidant lipid nanoparticles for safer and effective mRNA therapy! Free access: https://t.co/P5R9PEKz8F
1
11
87
Check out our latest collaborative work in @Biomaterials_ with @KaraSpillerLab @HannahGeisler_ @WeissmanLab on a new interleukin-4 mRNA lipid nanoparticle macrophage cell therapy to sustain a pro-reparative phenotype in inflammatory injuries! Open access: https://t.co/XeUJ3wX8yx
1
6
31
Check out our latest news and views article in Nature Nanotechnology @NatureNano led by @MJMitchell_Lab Postdoc Zhangyi Luo on @BowenLi_Lab's modular mRNA LNP platform for programmable induction of tumor-specific immunogenic cell death! Free access: https://t.co/THqbqkpZOS
0
5
27
Super exited to share our latest review in Cell Biomaterials @CellBiomat led by my PhD student Nei Li in collaboration with Profs. Ying Xu and Yinghui Wei on summarizing tools and delivery technologies for mitochondrial gene editing! Free access: https://t.co/DEhz5BvbCk
1
3
12
Check out our latest in @BioconjChem led by Hannah "Coach" Safford @hannahsafford_ on emerging nucleic acid cargos for next-generation RNA vaccines and therapeutics! Lookout for exciting saRNA and circRNA LNP projects from @MJMitchell_Lab this year! Link: https://t.co/AOm61ZfZXV
2
3
17
A huge thanks to @CHADNANO @DrMTeplensky for including us as part of this exciting PNAS special issue on structural immunotherapy:
pnas.org
The Structural Immunotherapy: Breakthroughs in Vaccine Development Fueled by Nanotechnology Special Feature highlights how nanoscience is revolutionizing vaccine design through structural immunothe...
0
4
8
Excited to share our latest in PNAS @PNASNews led by @MJMitchell_Lab Postdocs @JinjinWang40973 @ShiQiangqiang on a drug loaded bispecific T cell nanoengager platform to overcome T cell exhaustion for potent cancer immunotherapy! Open access: https://t.co/8zRIGJ91PB
1
2
22
Thousands of first-time homebuyers purchased a home this year thanks to our HomeReady® mortgage. Find out how.
8
10
166
This integrative approach represents a notable advance in LNP characterization, offering a more mechanistic understanding of how structural and biophysical attributes influence functional performance. - Another fantastic work by @MJMitchell_Lab and his team! @NatureBiotech
Research Briefing: Solution biophysics reveals the polydisperse structure of RNA lipid nanoparticles https://t.co/BpyiKnNvxF
https://t.co/c8RiMnLVG3
2
2
18
Huge shout out to @WeiTaoLab for the kind words about our study!
0
1
3
Check out our latest research briefing in @NatureBiotech led by @MJMitchell_Lab Postdoc Marshall Padilla showing how solution biophysics can reveal the polydisperse structure of RNA lipid nanoparticles! Briefing: https://t.co/3xbhbSdw5x Original Article: https://t.co/8enEoQW7t4
1
5
39
Had a blast at our inaugural @Dan_A_Heller @MJMitchell_Lab joint lab apple picking event @TerhuneOrchards! Great team bonding and collaboration building. We look forward to making it an annual tradition!
0
4
37
Insights Into Lipid Nanoparticle Structures Could Pave the Way to More Targeted Therapeutics Findings reveal that #LNPs come in a surprising variety of configurations. The differences correlate with their delivery capabilities @GuptaPenn @MJMitchell_Lab
https://t.co/o3Cy0RT0V0
genengnews.com
The findings reveal that LNPs come in a surprising variety of configurations and the differences correlate with their delivery capabilities.
0
4
19
Elucidating lipid nanoparticle properties and structure through biophysical analyses https://t.co/TVq9PT9ja0
2
20
68
Marshall is currently on the faculty job market, scoop him up while you can!
0
2
5
The latest Microsoft Research Forum episode is now available on-demand. Explore purposeful research and its real-world impact.
5
6
49
Thrilled to share our latest in @NatureBiotech led by @MJMitchell_Lab Postdoc Marshall Padilla in collaboration w @GuptaPenn on elucidating mRNA lipid nanoparticle structure through biophysical analyses! LNPs can have crazy shapes, see below: Free access: https://t.co/Idkn6t7FZO
4
10
63
A surprise bonus from COVID-19 vaccines: bolstering cancer treatment | Science | AAAS
science.org
Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer
0
4
7
Check out our latest in Nanoscale Horizons co-led by @MJMitchell_Lab Postdocs and PhD students Melgious Ang, Ann Metzloff, and @ASThatte2 on lipid nanoparticles for engineering next generation CAR T cell immunotherapy! https://t.co/6LKSYH66k3
pubs.rsc.org
Lipid nanoparticles are a burgeoning technology which has vast potential to improve chimeric antigen receptor (CAR) T cell immunotherapy. This focused review provides an overview of CAR T cell...
0
2
26
Excited to give a talk at the @ALSTDI Summit on our work on systemic mRNA lipid nanoparticle delivery to the brain! Great opening address by CEO Fernando Vieira!
0
2
22
The day wraps up with a panel discussion featuring all our symposium speakers reflecting on the future of nanoscience and where discovery goes next. #Nanoscience #IIN #Northwestern
0
1
10
Kabiller Rising Star Michael Mitchell from the University of Pennsylvania is showing how nanoscale materials are unlocking new ways to deliver medicine and treat disease. #KabillerPrize #Nanoscience #IIN
0
5
18