Müller Lab
@Devbiokonstanz
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We combine genetic, biophysical and theoretical approaches to understand self-organizing processes during development.
University of Konstanz
Joined April 2022
I won't try to summarize everything that happened at "The Woodstock of Biology 2 + Nightscience" (you can see on the other place under this hashtag #TCTeAC) I'll just say that it was an out of body experience, and, in my opinion, historical. #theconferencetoendallconferences
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Proof of Concept Grant @ERC_Research für #UniKonstanz Biologe Patrick Müller + sein Projekt „EmbryoNet-AI“. Ziel ist die Weiterentwicklung einer KI-gestützten Plattform zur automatisierten Auswertung von Experimenten: https://t.co/rpcCApLaqN
@Danielkocapek @Devbiokonstanz @CBehav
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Woop-woop! The work, which started as a part of my 2014-18 FWF grant is finally finished and published https://t.co/tcdhNBSJ4X. Here’s an X-plainer 🧵
elifesciences.org
ChIP-seq analysis reveals BMP signaling targets in a cnidarian and identifies ZSWIM4-6 as a dampener of the pSMAD1/5 gradient and a potential conveyor of the BMP-mediated gene repression.
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Preview in @CellSystemsCP by @Devbiokonstanz on the latest study from @ElowitzLab - Key signaling pathways seem to use their components in only a handful of combinations, suggesting that they operate in specific modes - similar to selecting specific chords from musical scales.
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Collective behaviour is all around. The Cluster of Excellence @CBehav @UniKonstanz and @MPI_animalbehav investigates #collectivebehaviour since 2019! With this film we invite you to take a look at our research and dive into the swarm to learn more about us. @dfg_public
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Read our latest #research article "Uncovering developmental time and tempo using deep learning" published with @SpringerNature in @naturemethods: https://t.co/t9ex7YZw1s
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Recent paper by @rkharish93 uses a #zebrafish FGF8-EGFP knock-in to quantify its #morphogen gradient “providing a functional proof for the morphogenic action of endogenous Fgf8a, consistent with Wolpert's French flag hypothesis” https://t.co/SSb1qF7B1m
journals.biologists.com
Highlighted Article: The endogenous distribution of a morphogen directly visualized for the first time in a living vertebrate species and studied to assess the importance of extracellular diffusion...
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"The biological cell is a thermodynamic analog and stochastic (noisy) supercomputer: It performs reliable computation with unreliable and noisy parts on stochastic signals." #CellBiology #Bioenergetics
https://t.co/ZbTAPe1wls
pmc.ncbi.nlm.nih.gov
Boltzmann-exponential thermodynamic laws govern noisy molecular flux in chemical reactions as well as noisy subthreshold electron current flux in transistors. These common mathematical laws enable...
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"An amazing week with a diverse group of students delving into physics and computing. Their remarkable presentations were filled with passion and enthusiasm for science! Let's carry this spirit of curiosity and collaboration forward!" Hernan Morales-Navarrete (PWF Ecuador)
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Super happy to share that @Danielkocapek and I got the Best Paper Award (BPA) SS 2023 of the Biology Department @UniKonstanz for our #EmbryoNet paper in @naturemethods. Thanks to everyone that contributed to the work @notionbyanica @Devbiokonstanz @CV_Studio_
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Are you a developmental or cell biologist? Looking for an alternative social media platform? Wouldn't it be good if it was especially for biologists to discuss science, research, teaching...? Yes? Try @Co_Biologists Mastodon server @biologists.social https://t.co/rlkvnHe2VS
biologists.com
29 June 2023 The Company of Biologists has launched a new server on Mastodon: biologists.social. It is a space for biologists to discuss science, research, teaching, life and more. Who is the server...
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One hundred years of wave equations of physical systems from Schrödinger's model of the atom to neural field theory of the brain Both formulations predict that the system's expressed energy is constrained into natural modes - "eigenstates - determined by the system's geometry
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AI-based detection of embryonic developmental defects in animals: #UniKonstanz researchers from the Müller Lab (@Devbiokonstanz; @CBehav) published the open source image analysis tool EmbryoNet in @naturemethods. Full story: https://t.co/liW2fLfMwM
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Out today! EmbryoNet is an automated approach for phenotyping developing embryos that surpasses experts in speed, accuracy and sensitivity. A large annotated image dataset of zebrafish, medaka and stickleback development rounds out this Resource. https://t.co/k7eEYRPZN7
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THIS THURSDAY May the 4th be with you! We will hear exciting research from @Danielkocapek (@Devbiokonstanz) & @SpartanS100tist (@gastrulateordie lab)! See you there at 12:30 PM EDT 👋
Next Thursday May 4th @SpartanS100tist from the @gastrulateordie lab will tell us about tissue stiffness & 🐸 gastrulation, & @Danielkocapek from @Devbiokonstanz will reveal how to use deep learning to connect phenotypes and signaling pathways. See you there!
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Next Thursday May 4th @SpartanS100tist from the @gastrulateordie lab will tell us about tissue stiffness & 🐸 gastrulation, & @Danielkocapek from @Devbiokonstanz will reveal how to use deep learning to connect phenotypes and signaling pathways. See you there!
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What sounds do drosophila larvae, bees, and zebrafish make? Students at the @merzakademie created virtual reality worlds for these animals in collaboration with CASCB researchers. The project results: https://t.co/cRep1YYdJq
@Devbiokonstanz @KatrinVogt3 @UniKonstanz
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