David E Sanin
@DavidESanin
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Assistant Professor at Johns Hopkins University and macrophage enthusiast! | he/him 🏳️🌈
Joined April 2021
Unfortunately this place has become toxic. I’ll be over where the sky is more blue! 🦋Join me there! @davidesanin.bsky.social
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Congrats to @mara_mennuni and @NilsGoranLarss1 on their new study!! Read all about how mitochondrial DNA shaped tumor progression! High mitochondrial DNA levels accelerate lung adenocarcinoma progression | Science Advances
science.org
High mtDNA levels increase tumor burden in mice through enhanced mitochondrial respiratory chain capacity.
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🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! Now on early publication @AnnualReviews🚀📜 https://t.co/Qm5fQQ3AGQ
@tatjana_kleele @SulianaManley @SteppWilli
#Quantitative #Microscopy #SuperResolution #CellBiology
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Budding flower of our poem to the science of prostate cancer Table 4 - #PCFRetreat24 @DavidESanin @Alexandros_P @MarkSalji @Fletcher_C @PCFnews @PCF
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Amazing mentor and inspiring scientist! Plus Glasgow is super cool!
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Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions @RESOLUTE_IMI, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter
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Online now! Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution https://t.co/ilBbLnMOXm
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UPDATED: we have identified 313 (!) funding opportunities and fellowships for postdoctoral fellows. Download this database freely here: https://t.co/EbTahdzJ9X For each entry, we provide description, amount, deadline, eligibility, and link to funder. Good luck!
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Macrophages are terrible at migrating. In contrast, their precursor cells - monocytes - are highly motile. Monocytes exploit interleukin 6 (IL-6) secreted by cancer cells and themselves to migrate fast and promote cancer cell proliferation. More here: https://t.co/r2uyQ2I6pB
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Is it always possible to assign #GeneExpression #CellStates to #SingleCells? Or can biological noise set fundamental limits? In our new work, we show that #CircadianClock states *cannot* be assigned to single cells due to transcriptional noise! https://t.co/bWRda1d9PT (1/8)
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For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. https://t.co/J9xnnt0xXD
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Very excited to have Mellon out in @naturemethods today!
Mellon accurately estimates cell-state densities using high-dimensional single-cell data, unveiling regulatory dynamics and mechanisms in cell differentiation. https://t.co/3xfstDZRqr
@SettyM @fredhutch
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There's been amazing coverage of our new paper @Nature
https://t.co/qkrUksBYVW but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...
nature.com
Nature - ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human...
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Excited to share our new study on the heterogeneity of interstitial macrophages based on their chemokine expression -conserved in humans and mice- a major role is to orchestrate leukocyte recruitment and establish TLS formation. @XinLi0419 @ArlindUC17
https://t.co/ceXaz91VEB
nature.com
Nature Immunology - Jakubzick and colleagues show that interstitial macrophages across various tissues display similar coordinated chemokine signatures in humans and mice.
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This represents how we believe haematopoiesis is actually proceeding at a clonal level. I'll walk through our preprint early next week. "A multi-track landscape of haematopoiesis informed by cellular barcoding and agent-based modelling" https://t.co/Wnhi6095Rb
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Inspiring innate immunology & systems biology research at this years @KeystoneSymp. Grateful to get the chance to discuss our translational immunology work on anti-bacterial innate immune cell function from the HOPE-SAM study @ZvitamboZim
https://t.co/EgwtDwlAsG
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Happy to announce 1st of several papers/preprints to drop from our lab, by Cerise Tang and co-led by Justin Jee. The first 1-figure paper I've written but not the last, the title says it all: Obesity shapes the selection of driver mutations in cancer
medrxiv.org
Obesity is a leading risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. Here, we examined the relationship between obesity and tumor genotype in...
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Awesome thread!
Learning how to “read” the genome is a basic skill for all biologists. As an introduction, here’s a 🧵 about using the genome browser to make a discovery about how we lost our tails. All you need is your 'thinking eye'! (1/13)
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Always important to try new integration methods! Specially when balancing correction vs. data loss!! Excited to try this out!!
In scRNA-seq analysis, "overcorrection" of batch effects is a frequent cause for loss of important biological variability. Using prior celltype knowledge is a powerful way to limit overcorrection and should be more common practice. Sharing new preprint! https://t.co/j9qB7kLumH
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