Aaron Johnson
@ChromaTownie
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CU School of Medicine Faculty, Studying Heterochromatin he/him/his
Denver, CO
Joined June 2018
I can't say enough great things about all that Allison can bring to your department! She's been an amazing member of my lab, but our loss will be your gain, as well as hers.
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The fabulous Pragya Sidhwani @pra_sidh wrote this nice article about ideas for how cells build boundaries between chromatin domains, particularly the centromere! https://t.co/h3sL1MAAld Would love to hear other ideas for this question. #heterochromatin #centromere #boundaries
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The final version of our Cas4/1 dual-nuclease activity study is now out @jbiolchem! Congrats @yukti__dhingra!
Happy to share our new preprint! @yukti__dhingra found that both domains of a type I-G Cas4/1 fusion have nuclease activities. Each domain cleaves one end of a prespacer, allowing for prespacer selection, processing, and integration all in one adaptation complex!
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LMU is hiring an Assistant Professor in the area of Biochemistry to begin in August 2024. We hope to attract a highly qualified, diverse, and broad applicant pool. Applications are due Oct 2, 2023. Please spread the 🗞️! Link to the job ad is within the tweet.
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Our collaborative work @CRBM_Montpel with the group of Patrick Schultz @IGBMC on how the NuA4 complex modifies nucleosomes at a distance is now online: https://t.co/HhrYyA0kpf Congrats to my great tech and 2nd-author Céline Faux. Thx @AgenceRecherche and @INSB_CNRS for support
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https://t.co/cMGLJI8PGW
@eLife We are so excited about our new paper defining a new link between splicing and transcription!
elifesciences.org
Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes...
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📯 Our work on a new core splicing factor is out in @MolecularCell! FUBP1 is important for splicing of long introns. Multivalent interactions support spliceosome assembly and intron bridging. Great collab with @Sattler_lab & Luck_lab. Check it out here: https://t.co/eb8TBuRZbr
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Paper alert ‼️ 🚨 What is the role of RNA in the initiation of DNA replication? We have answers to this long standing question. Yes, RNA has a lot to say in how and where origins are activated. Check out our paper by amazing first author @AinaMMas
https://t.co/2VqLrVKSig
nature.com
Nature Communications - Here the authors describe that the human origin recognition complex subunit 1 (ORC1) binds to RNAs transcribed from genes with origins of replication at their TSS impacting...
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Proud of these two Hinkley High @aurorak12 grads that have worked in the lab for 1-2 summers. They’ve grown into full-fledged members of the lab and have contributed a lot to this @nsf sponsored project on molecular epigenetics.
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The use of cryoEM to study RNA structures is on the upswing, with the need for more tools and techniques. In this preprint, Conner Langeberg describes his "scaffold-based" approach to visualize small folded RNAs.
biorxiv.org
Single-particle cryo-electron microscopy (cryo-EM) can reveal the structures of large and often dynamic molecules, but smaller biomolecules remain challenging targets due to their intrinsic low...
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https://t.co/yVGKhFIQPi This paper by two amazing co-first author Emory grad students represents an incredible collaboration of @emorygmb and @EmoryBCDB grad programs from @bjalloh66 and twitterless Carly Lancaster- published @eLife under the previous model (in case anyone asks)
pubmed.ncbi.nlm.nih.gov
The Drosophila polyadenosine RNA binding protein Nab2, which is orthologous to a human protein lost in a form of inherited intellectual disability, controls adult locomotion, axon projection,...
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Our lab website is now live! Explore opportunities and learn about our research on telomere-mitochondria-innate immunity crosstalk at
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Please RT! My department is recruiting a mid-career/senior faculty member in structural biology/biophysics to join us. Highly-collegial, fantastic science/scientists. Great initiatives for diversity, equity, and anti-racism, all spearheaded by our excellent chair @promiselcooper.
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Happy to share our new publication out @Nature
https://t.co/Q9G3XzkNio, where we investigated how MYC-MAX and CLOCK-BMAL1 engage chromatinized E-boxes. Thanks to all the collaborators! @SchubelerLab @partchlab @Beatfierz @johannes_zuber @jsmenet @RalphSGrand @PriyaCrosby
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This sums it up perfectly.
“When you are accustomed to privilege, equality feels like discrimination”
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Happy to share that I've been awarded tenure @CUAnschutz ! Thanks to my whole lab through the years and my colleagues, esp. in our fantastic BMG department, for supporting my science and overall career. Here's to many more years! 🥂
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