Aina Mª Mas Calafell
@AinaMMas
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Chromatin, epigenetics, and non-coding RNA
London, England
Joined December 2017
Can distinct repressive histone PTMs substitute for one another? We found that H3K9me3 and H3K36me3 can only partially compensate for loss of H3K27me3 https://t.co/Kf0thCbd0Z
@NatureComms @helin_kristian @LinHedehus Our results support the concept of a combinatorial histone code
nature.com
Nature Communications - Hedehus et al. show that H3K9me3 and H3K36me3 can only partially compensate for loss of H3K27me3, supporting the concept of a combinatorial histone code.
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📢 Progress from Cima: researchers develop ELATUS, a tool that detects long non-coding RNAs (lncRNAs), key in diseases such as cancer. 🔬 We detected the lncRNA AL121895.1, essential in breast cancer proliferation. 🔗 More details 👇
cima.cun.es
Este trabajo, realizado por investigadores e ingenieros del Cima Universidad de Navarra, facilita el desarrollo de terapias más precisas.
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🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting.. Check it out here: https://t.co/mfsDO3kKa0
#Genomics #Epigenetics
biorxiv.org
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessi...
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Thrilled to announce that ELATUS is out in @NatureComms! ELATUS uncovers functional lncRNAs in scRNA-seq missed due to poor annotation, such as AL121895.1, involved in breast cancer, providing insights into lncRNA biology. @MaiteHuarteLab @mikelhernaez
https://t.co/7RSt30bMq9
nature.com
Nature Communications - The inaccurate annotation of long noncoding RNAs (lncRNAs) hampers their detection by scRNA-seq. The computational workflow ELATUS, based on the pseudoaligner Kallisto,...
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Queremos contaros que La Fundación para el conocimiento Madri+d @madrimasd ha otorgado a @dcienciablog uno de sus premios de Ciencia en Español. ¡Muchas gracias por el reconocimiento! Gracias a todos los científicos que habéis colaborado con nosotros y a nuestros lectores.
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Europa financia con 1,5 millones la investigación de Guillem Ripoll, profesor de @EconomUnav. Ha recibido la beca 'Starting Grant' del @ERC_Research para analizar y prevenir el comportamiento iliberal en la administración pública. #ERCStG 👉 https://t.co/SXMirXrJHX
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🚨 Paper Alert! 🚨 Does RNA regulation impact the p53 pathway and DNA damage response? We reveal distinct m6A-dependent and independent functions of the YTHDC1 protein. Proud of the work by @BlazquezElvira @CIMA_unav, collaboration with @raimondi_ivan @nygenome 🔗 Read here 👇
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Do you want to know how we're using #AI to fight cancer? Join us in the pub at the ICR's @pintofscience to hear our researchers talking about their work. 📅15 May 📍The Prince Albert Battersea SW11 4PF 🗣️@stephensammut & @boragurel Book now: https://t.co/WiauV5w9h8
#Pint24
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Thrilled to finally share this work! @MaiteHuarteLab and I delve into the interplay between RNA regulation and DNA damage finding that "YTHDC1 m6A-dependent and m6A-independent functions converge to preserve DNA damage response"!
biorxiv.org
Cells have evolved a robust and highly regulated DNA damage response to preserve their genomic integrity. Although increasing evidence highlights the relevance of RNA regulation, our understanding of...
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A must read!!! Congratulations @kike411
Are all gene types equally targeted in scRNA-seq?? No! The essential and cell-type specific lncRNAs are largely overlooked by standard pipelines. Here, we present ELATUS, a workflow tailored to lncRNA in scRNA-seq @MaiteHuarteLab @mikelhernaez 👇 https://t.co/MkbYOoZIlx
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Happy to share our latest paper in @NatureComms ! #lncRNA lncREST and its role in #replicativestress. Take home: lncREST associates to the stressed replication forks to recruit replication proteins to sites of DNA replication! @MaiteHuarteLab
https://t.co/AEK3XGT1L1 A 🧵:
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📢 Paper alert! Can a chromatin-associated lncRNA impact replication stress? Dive into the details of how lncREST localizes at stressed replication forks and enhances the assembly of fork signaling factors. Work led by ⭐️@LuisaStatello
https://t.co/aruDDI4KeU
nature.com
Nature Communications - Replication stress represents a major threat to genome integrity of normal and cancer cells. Here, the authors find that the long non-coding RNA lncREST affects the...
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Científicos españoles han descubierto que el ARN que se está “fabricando” es capaz de regular la replicación del ADN. La Dra. @AinaMMas, primera autora del trabajo nos cuenta el novedoso descubrimiento. @CIMA_unav @NatureComms
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Paper alert ‼️ 🚨 What is the role of RNA in the initiation of DNA replication? We have answers to this long standing question. Yes, RNA has a lot to say in how and where origins are activated. Check out our paper by amazing first author @AinaMMas
https://t.co/2VqLrVKSig
nature.com
Nature Communications - Here the authors describe that the human origin recognition complex subunit 1 (ORC1) binds to RNAs transcribed from genes with origins of replication at their TSS impacting...
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Sharing pizza is usually easy. Sharing data can be easy but it's often a bit less so. For my latest story, I chatted with some people all about this: To share is to be a scientist
nature.com
Nature Methods - Wrangling big data is now part of being a biomedical scientist, and mandates on data sharing have entered the scene. Mandates can alter behavior, but data sharing also needs...
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¡Comenzamos el Genomics Day!!! Una jornada para celebrar el 70 aniversario del #descubrimiento de la doble hélice 🧬 y 20anivesario de la finalización del #ProyectoGenomaHumano. Más de 70 #investigadores reunidos para aprender las bases y nuevas aplicaciones de la #genómica
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La expresión de unos ARN largos no codificantes (lncRNAs) predice la supervivencia y prognosis de los pacientes de leucemia mieloide aguda pediátrica. Os lo explica la Dra. @AinaMMas del @CIMA_unav. https://t.co/BkbnkARO1r Adaptado de https://t.co/0tz7tNHUVj
@ASCO
dciencia.es
Un estudio reciente publicado en la revista Journal of Clinical Oncology (JCO, 1) y en el que han participado científicos de hasta doce centros estadounidenses diferentes, ha revelado que, mediante...
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Understanding the pathway: Long Noncoding #RNA Signatures as Cancer Biomarkers @MaiteHuarteLab @JCO_ASCO @CIMA_unav
https://t.co/D9lxsdYJ1P
ascopubs.org
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📢📢A novel role for microRNA in controlling sex determination!! Check out our new pre-print! https://t.co/4u0ThVs9Ix
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14/14. RNA-binding occurs at ORC1 IDR, a region that also mediates ORC1 self-interactions, binding to other proteins, phosphorylation, and phase separation. How is all this connected? What are the functional implications? All questions deserving future investigation
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