Dr. Ceri Fielding
@CeriFielding
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Viral Immunology researcher in the Division of Infection and Immunity at Cardiff University. Views my own.
Cardiff, UK
Joined June 2014
Read the new review on hemophagocytic lymphohistiocytosis and the major biological and clinical advances regarding it in recent decades. https://t.co/tEfmV3SBjU
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Downregulation of the CD21 receptor triggers #extrafollicular differentiation of B cells, driving the formation and proliferation of autoantibody-secreting cells in mouse models of #lupus. Learn more in Science #Immunology: https://t.co/wa6LpNCeUm
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cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives "In the aging central nervous system (CNS), cellular senescence is accompanied by mitochondrial DNA (mtDNA) leakage, nuclear DNA damage, and other changes that may aberrantly
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Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus 🇨🇳 https://t.co/LR9o6vdQz7
https://t.co/gNqgdejTx5
@TheLancet
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📢#Postdoc opportunity in human T cell immunology in the Zielinski lab at the University of Cambridge @Cambridge_Uni. 👉Official job announcement coming up soon. DM me if you are passionate about the regulation of human #tissue-resident T cells. #Immunology @ERC_Research
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A groundbreaking paper by @younis_sh1 et al. @stanfordimmuno provides an answer to the long-standing question about how EBV infections are linked to lupus. A short thread to explain the key findings. (1/) https://t.co/dUpz19IjEv
science.org
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
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OAS1 and OAS3 genetic variants enhance inflammatory responses to SARS-CoV-2 @iScience_CP
https://t.co/RgJALrAU9S
@iibbcsic 🇪🇸
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Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell-generated cGAMP https://t.co/DAh5DlaEYb
@NatalieArtzi @MIT
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We are hiring! 🎓🧫 🧬 #PhD studentship available in #Immunology at #CambridgeUniversity to investigate a new killer function of human T cells. 📅 Application deadline: 3rd December 2025 more information: https://t.co/yT0hiLEqAg
#findaPhD @ERC_Research
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After two years of work, we’ve made an AI Scientist that runs for days and makes genuine discoveries. Working with external collaborators, we report seven externally validated discoveries across multiple fields. It is available right now for anyone to use. 1/5
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Lost in the ocean of #CRISPR_web_tools? Check out @CRISPR_GATE — our newly launched web portal that brings everything you need for CRISPR design, editing, and analysis in one place! #Cas #GlobalSouth Article: https://t.co/z3aFFPC36A Website: https://t.co/TSGdBFBjSx
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The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations https://t.co/DRumwL5MPL
@uofl @uddalok06 @CellGenomics
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A new Science #Immunology study shows that deleting the lysosomal protein Flcn from #Treg cells can prevent their accumulation in some tissues, thus boosting #antitumor immunity in mice. https://t.co/zEgdNsXV9r
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I’m so excited to share my third and final first-author publication from my PhD!! We discovered NK cells express fibroblast activation protein (FAP) and use it to migrate into tumors! FAP overexpressing NK cells reduced pancreatic cancer growth in mice!
academic.oup.com
Abstract. Natural killer (NK) cells play essential roles in immunity, but their limited infiltration into solid tumors restricts their therapeutic potentia
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Oliver et al do it again!
Pre-print alert! And this one really is a must read for anyone that does spectral flow cytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? https://t.co/BG3DVIM13r
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Thank youAlex @ABiederstadt_MD for a fantastic collaboration and all the thoughtful discussions. Your ideas and contributions made our review ‘Engineered NK cells for cancer therapy’ in @CancerCell possible! #NK #Immunotherapy #CRISPR #EndCancer @MDAndersonNews
Together with my mentor @lab_rezvani Katy Rezvani @MDAndersonNews, I am excited to share our new review in Cancer Cell: “Engineered natural killer cells for cancer therapy”. Deeply grateful for Katy’s mentorship and her visionary leadership. #CARNK #Immunotherapy #SolidTumors
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mRNA vaccines as unplanned immunotherapy primers ⚡ SARS-CoV-2 mRNA vaccination triggers a type I IFN surge, activates APCs, and primes CD8⁺ T cells for tumor antigen recognition. 🧩 IFN-driven PD-L1 upregulation 🧭 Enhanced T-cell infiltration into “cold” tumors 🌐
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A new study reveals how our cells fight the flu virus! TRIM45 helps block influenza infection by breaking down a key viral protein (PB2) through a natural clean-up process inside cells. #Influenzahttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013630
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Predicting protein-protein interactions in the human proteome Predicting which human proteins shake hands—and how—is a longstanding bottleneck. Proteins rarely act alone; they assemble into complexes that drive immunity, metabolism, signaling, and disease. But testing hundreds
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