Benjamin Parker
@BenParkerLab
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Research group of @Ben_Leo_Parker @UniMelb as we lost access to previous account. We love metabolic proteomics and signal transduction.
Melbourne, Victoria
Joined March 2024
An amazing opportunity with such a cool team!.
šØ Join Our Team! šØ.Weāre on the hunt for a brilliant postdoctoral researcher with a passion for neuroscience or metabolic disease. This is your chance to work at the intersection of academia & industry, driving innovation in obesity & T2D research. š.
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Thanks for the leadership @MattWattUnimelb! Couldnāt have done it without you.
Thrilled that the metabolism theme in Dept of Anatomy & Physiology were awarded NHMRC and ARC grants in #obesity #MASLD, #fibrosis and #aging. Go ā¦@garrondoddā© ā¦@Ben_Leo_Parkerā© ā¦@MagdaMontg64866ā© ā¦ā¦@MattWattUnimelbā© ššÆš ā¦@UniMelbMDHSā©
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RT @PMV_Australia: Abstract submissions are closing in a few weeks! Register now for the free WEHI Proteomics Symposium co-hosted by PMV. hā¦.
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A big thanks to @UniMelbMDHS and @CellSignal for supporting this research, and several collaborators @UniMelbCMR @JamesMc2327 @CraigAGoodman1 @OchDr @NgoShyuan and many others!.
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Why do we care? Because we have previously shown that UFC1 levels are negatively correlated with lean mass in various mouse strains, and knockdown of UFC1/UFMylation can increase muscle function. Maybe myosin UFMylation is a key link? .
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We quantified UFMylation in the above human biopsies revealing several increased UFMylation sites including Myosins! Additional mapping of sites on Myosins reveal they are extensively modified, and in silico modelling suggest sites adjacent to ATP binding plays a functional role.
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What did we find?. A whole bunch of cool substrates including UFMylation of Myosins which we validate following knockdown of UFC1 (the E2 ligase) in vivo combined with TMT-16plex labelling and LC-MS/MS
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With @CellSignal, we developed antibodies that recognise "remnant ValGly" left on UFM1-conjugates following tryptic digestion. Similar to the remnant ubiquitin "diGly" approach published by @GygiLab
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However, check out this anti-UFM1 blot from control muscle biopsies and people with ALS. A big band at 30kDa (probably RPL26) but clearly more to discover including big heavy bands >250kDa! .
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UFMylation is a ubiquitin like modification of UFM1 applied to substrate lysine residues. <15 substrates have been identified (a nice summary: . RPL26 has been most extensively characterised and suggested to be the major substrate:
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Check out our new #proteomic method to site-specifically quantify UFMylation! We applied the approach to look at human skeletal muscle biopsies from #ALS. A great collaboration with @CellSignal and many others. A little summary below.
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Extremely proud of Kits PhD journey and amazing Oration. Thanks @MattWattUnimelb and @GordonSLynch for all the support throughout the years.
Kit Ng presenting his final PhD oration on exercise phosphoproteomics and skeletal muscle at Dept of Anatomy and Physiology. Awesome to see the journey. @BenParkerLab @UniMelbMDHS
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RT @Yanshen73854711: Introducing our new study @ Tissue-PPT, an Extensive Atlas of Proteome and Phosphoproteome Turnover across mouse tissuā¦.
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RT @PMV_Australia: Registrations and abstracts are now open for the free WEHI Proteomics Symposium (Feb 6th 2025), co-hosted by PMV. Detailā¦.
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RT @Vivekdna: Congratulations to ā¦colleagues Gary Churchill (ā¦@jacksonlab)ā© & Andrea Di Francesco (Calico) on this landmark publication. Weā¦.
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A fantastic opportunity!.
Our lab is looking for a postdoc @uwgenome/@UW/@UWISCRM!. We tackle a wide range of biological Qs from cell-specific responses to perturbation to molecular consequences of aging. We also work hard on new #TeamMassSpec methods to scale the # of proteomics samples we can analyze.
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Congratulations @garrondodd and team for these exciting results showing accumulation of ECM during metabolic disease has a major impact on insulinās engagement with its receptor in the brain!.
Excited to share our latest research published inĀ Nature, revealing the crucial role of the brain's extracellular matrix in obesity and diabetes. Thanks to @CaitBeddows, @MrEdwardMoh, @UniMelb & our funding partners @nhmrc, @arc_gov_au and @DiabetesAus.
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Hi #TeamMassSpec and #proteomics Does anyone know what happened to the Chorus Project Repository? We are trying to access old data but canāt get in contact with the team to confirm login. Original authors only retained processed rather raw data. Thanks
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RT @us_hupo: Proteomics Turns 30! It is thirty years since Prof. Marc Wilkins (then an early career researcher) introduced the term "proteoā¦.
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RT @DPhaz: We are looking for a Postdoc to investigate novel genes that regulate insulin-stimulated glucose transport (.
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